ID   DNAK_PORG3              Reviewed;         640 AA.
AC   B2RJ90; Q9ZAD3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=PGN_0916;
OS   Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM
OS   12257 / NCTC 11834 / 2561).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC   Porphyromonas.
OX   NCBI_TaxID=431947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10100860; DOI=10.1016/s0014-5793(99)00237-9;
RA   Yoshida A., Nakano Y., Yamashita Y., Oho T., Shibata Y., Ohishi M.,
RA   Koga T.;
RT   "A novel dnaK operon from Porphyromonas gingivalis.";
RL   FEBS Lett. 446:287-291(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561;
RX   PubMed=18524787; DOI=10.1093/dnares/dsn013;
RA   Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H.,
RA   Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T.,
RA   Nakayama K.;
RT   "Determination of the genome sequence of Porphyromonas gingivalis strain
RT   ATCC 33277 and genomic comparison with strain W83 revealed extensive genome
RT   rearrangements in P. gingivalis.";
RL   DNA Res. 15:215-225(2008).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; AB015879; BAA35087.1; -; Genomic_DNA.
DR   EMBL; AP009380; BAG33435.1; -; Genomic_DNA.
DR   RefSeq; WP_012457876.1; NZ_CP025930.1.
DR   AlphaFoldDB; B2RJ90; -.
DR   SMR; B2RJ90; -.
DR   STRING; 431947.PGN_0916; -.
DR   PRIDE; B2RJ90; -.
DR   EnsemblBacteria; BAG33435; BAG33435; PGN_0916.
DR   GeneID; 29256128; -.
DR   KEGG; pgn:PGN_0916; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_10; -.
DR   OMA; ISIKRHM; -.
DR   BioCyc; PGIN431947:G1G2V-1011-MON; -.
DR   Proteomes; UP000008842; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Stress response.
FT   CHAIN           1..640
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000119739"
FT   REGION          602..640
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         197
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
FT   CONFLICT        169
FT                   /note="E -> D (in Ref. 1; BAA35087)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        293..295
FT                   /note="TLT -> RLR (in Ref. 1; BAA35087)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   640 AA;  69044 MW;  1469F7ED48AB4EBC CRC64;
     MGKIIGIDLG TTNSCVSVLE GNEPIVITNS EGKRTTPSVV AFVDGGERKV GDPAKRQAIT
     NPTKTIYSIK RFMGETYDQV SREVERVPFK VVRGDNNTPR VDIDGRLYTP QEISAMILQK
     MKKTAEDYLG QEVTEAVITV PAYFNDAQRQ ATKEAGEIAG LKVRRIVNEP TAASLAYGLD
     KSNKDMKIAV FDLGGGTFDI SILELGDGVF EVKSTNGDTH LGGDDFDHVI IDWLAEEFKS
     QEGVDLRQDP MAMQRLKEAA EKAKIELSST SSTEINLPYI MPVNGIPKHL VMTLTRAKFE
     QLADRLIQAC VAPCETALKD AGMSRGDIDE VILVGGSTRI PAIQEIVEKI FGKAPSKGVN
     PDEVVAVGAA IQGGVLTGEV KDVLLLDVTP LSLGIETMGG VMTRLIDANT TIPTKKSEIF
     TTAVDNQPSV EIHVLQGERS LAKDNKSIGR FNLDGIAPAP RQTPQIEVTF DIDANGILNV
     TAHDKATGKK QNIRIEASSG LSDDEIKRMK EEAQANAEAD KKEKERIDKI NQADSMIFQT
     EKQLKELGDK FPADKKAPID TALDKLKEAH KAQDVAAIDT AMAELQTALT AAGEELYKNV
     GAAQGGAQPG PDFGGAQGPS VGDQPSDDKN VTDVDFEEVK