ID   DNAK_PSEAE              Reviewed;         637 AA.
AC   Q9HV43;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Chaperone protein DnaK;
DE   AltName: Full=HSP70;
DE   AltName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=Heat shock protein 70;
GN   Name=dnaK; OrderedLocusNames=PA4761;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; AE004091; AAG08147.1; -; Genomic_DNA.
DR   PIR; B83052; B83052.
DR   RefSeq; NP_253449.1; NC_002516.2.
DR   RefSeq; WP_003095212.1; NZ_QZGE01000018.1.
DR   AlphaFoldDB; Q9HV43; -.
DR   SMR; Q9HV43; -.
DR   STRING; 287.DR97_2105; -.
DR   World-2DPAGE; 0008:Q9HV43; -.
DR   PaxDb; Q9HV43; -.
DR   PRIDE; Q9HV43; -.
DR   EnsemblBacteria; AAG08147; AAG08147; PA4761.
DR   GeneID; 881765; -.
DR   KEGG; pae:PA4761; -.
DR   PATRIC; fig|208964.12.peg.4987; -.
DR   PseudoCAP; PA4761; -.
DR   HOGENOM; CLU_005965_2_1_6; -.
DR   InParanoid; Q9HV43; -.
DR   OMA; ISIKRHM; -.
DR   PhylomeDB; Q9HV43; -.
DR   BioCyc; PAER208964:G1FZ6-4874-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0071977; P:bacterial-type flagellum-dependent swimming motility; IMP:PseudoCAP.
DR   GO; GO:0051701; P:biological process involved in interaction with host; IMP:PseudoCAP.
DR   GO; GO:0030254; P:protein secretion by the type III secretion system; IMP:PseudoCAP.
DR   GO; GO:0043107; P:type IV pilus-dependent motility; IMP:PseudoCAP.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..637
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078518"
FT   REGION          603..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        622..637
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         199
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   637 AA;  68403 MW;  06EA32E906D486A9 CRC64;
     MGKIIGIDLG TTNSCVAILE NGNVKVIENA EGARTTPSII AYTNDGETLV GQPAKRQAVT
     NPQNTLYAVK RLIGRRFEEN VVQKDIQMVP YSIVKADNGD AWVEVKGQKM APPQISAEVL
     KKMKKTAEDY LGEPVTEAVI TVPAYFNDSQ RQATKDAGRI AGLDVKRIIN EPTAAALAYG
     LDKAKGDHTV IVYDLGGGTF DVSVIEIAEV DGEHQFEVLA TNGDTFLGGE DFDIRLIDYL
     VDEFKKESGI NLKGDPLAMQ RLKEAAEKAK IELSSTQQTD VNLPYVTADA SGPKHLNVKV
     SRAKLESLVE DLVQRTIEPC RTALKDAGLD VSDIHEVILV GGQTRMPLVQ KTVAEFFGKE
     ARKDVNPDEA VAVGAAIQGA VLAGDVKDVL LLDVTPLTLG IETLGGVMTG LIEKNTTIPT
     KKSQVFSTAD DNQGAVTIHV LQGERKQAAQ NKSLGKFDLA DIPPAPRGVP QIEVTFDIDA
     NGILHVSAKD KATGKQQSIV IKASSGLSED EIQQMVRDAE ANAEEDRKFE ELAAARNQGD
     ALVHATRKMI TEAGDKATAE DKATIEKALG ELEAAVKGDD KAEIEAKMNA LSQASTPLAQ
     KMYAEQAQQG EDAPQGEQAK AADDVVDAEF EEVKDNK