ID   DNAK_SYNAS              Reviewed;         637 AA.
AC   Q2LUH6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=SYNAS_18590;
GN   ORFNames=SYN_01983;
OS   Syntrophus aciditrophicus (strain SB).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Syntrophales; Syntrophaceae;
OC   Syntrophus.
OX   NCBI_TaxID=56780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB;
RX   PubMed=17442750; DOI=10.1073/pnas.0610456104;
RA   McInerney M.J., Rohlin L., Mouttaki H., Kim U., Krupp R.S.,
RA   Rios-Hernandez L., Sieber J., Struchtemeyer C.G., Bhattacharyya A.,
RA   Campbell J.W., Gunsalus R.P.;
RT   "The genome of Syntrophus aciditrophicus: life at the thermodynamic limit
RT   of microbial growth.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:7600-7605(2007).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP000252; ABC77738.1; -; Genomic_DNA.
DR   RefSeq; WP_011417760.1; NC_007759.1.
DR   AlphaFoldDB; Q2LUH6; -.
DR   SMR; Q2LUH6; -.
DR   STRING; 56780.SYN_01983; -.
DR   PRIDE; Q2LUH6; -.
DR   EnsemblBacteria; ABC77738; ABC77738; SYN_01983.
DR   KEGG; sat:SYN_01983; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_7; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000001933; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..637
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000059690"
FT   REGION          597..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         198
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   637 AA;  68469 MW;  839E9DBC74587927 CRC64;
     MGRIIGIDLG TTNSCVAVME GGDPVVIANQ EGNRTTPSIV AFTESGERLV GQVAKRQAVT
     NSENTVYAVK RLIGRKYNSK EVQYDKSISP FKISEAPNGD AQIEVRGRAY SPAEISSMVL
     VKMKQTAEDY LGEKITDAVI TVPAYFNDSQ RQATKDAGKI AGLNVLRIIN EPTAAALAYG
     LDKKKDEKIA VFDLGGGTFD ISILELGEGV FEVKSTNGDT HLGGEDFDQR IIDYLVSEFK
     KDQGIDIRSD KMALQRLKEA AEKAKMELSS SMETDINLPF ITADASGPKH MNIKLTRARM
     EALVEELIDR LEGPCRTALK DAGLSPKDID EVILVGGMTR MPRVQQKVKE IFDREPHKGV
     NPDEVVAVGA AIQGGVLGGE VKDVLLLDVT PLSLGIETLG GVMTKLIEKN TTIPTRKSQI
     FSTAADNQPA VSIHVLQGER SMAGDNRTLG RFDLVGIPPA PRGIPQIEVT FDIDANGIVH
     VSAKDLGTGK EQSIKITASS GLSETEIEKL VREAESHGEE DRKKKELVEA RNSADAMAYG
     VEKNIKEFGD KVDAAEKARI EDAIAKVRKA VEGDDINAIR SAQDELTTAS HKLAEAMYAK
     TSQAGAGPQP GAGPGTGGQG PGKKDEDVVD ADFEEVK