ID   DNAK_THISH              Reviewed;         641 AA.
AC   B8GNX1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=Tgr7_0972;
OS   Thioalkalivibrio sulfidiphilus (strain HL-EbGR7).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Thioalkalivibrio.
OX   NCBI_TaxID=396588;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HL-EbGR7;
RX   PubMed=21475584; DOI=10.4056/sigs.1483693;
RA   Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N.,
RA   Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.;
RT   "Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7.";
RL   Stand. Genomic Sci. 4:23-35(2011).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP001339; ACL72060.1; -; Genomic_DNA.
DR   RefSeq; WP_012637544.1; NC_011901.1.
DR   AlphaFoldDB; B8GNX1; -.
DR   SMR; B8GNX1; -.
DR   STRING; 396588.Tgr7_0972; -.
DR   PRIDE; B8GNX1; -.
DR   EnsemblBacteria; ACL72060; ACL72060; Tgr7_0972.
DR   KEGG; tgr:Tgr7_0972; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_6; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000002383; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..641
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000133169"
FT   REGION          577..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         199
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   641 AA;  69312 MW;  F0801F1E9D682930 CRC64;
     MGKIIGIDLG TTNSCVAVME GDKAKVIENA EGARTTPSIV AFTEDGEVLV GQAAKRQAVT
     NPKNTLFAVK RLIGRRFEEP EVQKDIKLVP YEIFKADNGD AWVRVRDKKM APPEISARVL
     QKMKKTAEDY LGEPVTEAVI TVPAYFNDSQ RQATKDAGKI AGLEVKRIIN EPTAAALAYG
     LDKKRGDSKV AVYDLGGGTF DVSIIEIAEV DGEHQFEVLA TNGDTFLGGE DFDMRLIDYL
     VEEFKKEQGI DLKGDPLAMQ RLKESAEKAK IELSSSQQTD VNLPYITADA SGPKHMNIKV
     TRAKLESLVE ELIKRTIEPC KVALKDAGLS VSDIDDVILV GGQTRMPKVQ DAVKNFFGKE
     PRKDVNPDEA VAVGAAIQAG VLGGEVKDVL LLDVTPLSLG IETLGGVMTK LIEKNTTIPT
     KATQVFSTAD DNQTAVTVHV LQGEREMASA NKSLGRFDLT DIPPAPRGVP QVEVMFDIDA
     NGILNVSAKD KATGKQQSIV IKASSGLSDE EVERMVRDAE AHADEDKRFH ELVAARNQAD
     NLVHATEKSL KELGDQVEAG EKQAIESALS ELREAMKGDN KDEIETRTQK LAEASGKLAE
     RVYAKQSAEG GAGEGAGAEQ ASAQQDDVVD AEFEEVDDKK K