ID   DNAK_TREDE              Reviewed;         646 AA.
AC   Q73Q16;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=TDE_0628;
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243275;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104;
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G.,
RA   Malek J.A., Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K.,
RA   Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E.,
RA   Baca E., Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; AE017226; AAS11123.1; -; Genomic_DNA.
DR   RefSeq; NP_971242.1; NC_002967.9.
DR   RefSeq; WP_002681815.1; NC_002967.9.
DR   AlphaFoldDB; Q73Q16; -.
DR   SMR; Q73Q16; -.
DR   STRING; 243275.TDE_0628; -.
DR   EnsemblBacteria; AAS11123; AAS11123; TDE_0628.
DR   GeneID; 2739353; -.
DR   KEGG; tde:TDE_0628; -.
DR   PATRIC; fig|243275.7.peg.606; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_4_12; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..646
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000226025"
FT   REGION          599..646
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..627
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         197
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   646 AA;  69759 MW;  2A61E0B4C74F06C8 CRC64;
     MGKIIGIDLG TTNSCVSVME GGEPVVIPNS EGGRTTPSIV GFTSKDERVV GQPAKNQMIT
     NPERTVYSVK RFIGHRYSEL TDELKRVPYK IVPQGEDVRI DIDGKLYSTQ EISAFILQKM
     KKTAEDYLGE TVTEAVITVP AYFNDAQRQA TKDAGKIAGL EVKRIINEPT AASLAFGFNK
     DSKKEKTIAV YDLGGGTFDI SILELGDGVF EVKSTNGDTH LGGDDFDNRI VNWLVDEFKK
     DTGIDLSKDR MALQRLREAA EKAKIELSSV ANTEVNLPFI TADANGPKHL QKSLSRAKFE
     QMTEDLFERT KEPCRKALKD AGITPDKIDD ILLVGGSTRM PKVLQIIKEI FGKEGSKSVN
     PDEAVAMGAA IQGGILGGDV KDVLLLDVTP LSLGIETMGG VFTPLINRNT TIPTRKSQVF
     STAADGQTAV SIHVLQGERG MASQNRTLGN FDLVGIPPAP RGVPQIEVTF DIDANGIVHV
     SAKDLGTGKE QHIRIESSSG LSESEIDRMV KEAEANAEND KLEKEKVEAK NNADSLIYQT
     EKTLKEMGDK IGAADKQKIE AAIADLRQAL NSDNTADIKA KTENLQQAAY KIAEEMYKQQ
     GAQAGADPNA GSSQGAQAGT DYGTSGPKTG TADDVDYEVV NDDNDK