ID   DNAK_TREPA              Reviewed;         635 AA.
AC   O83246;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Chaperone protein DnaK;
DE   AltName: Full=HSP70;
DE   AltName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=Heat shock protein 70;
GN   Name=dnaK; OrderedLocusNames=TP_0216;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000250}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; AE000520; AAC65204.1; -; Genomic_DNA.
DR   PIR; F71352; F71352.
DR   RefSeq; WP_010881664.1; NC_021490.2.
DR   AlphaFoldDB; O83246; -.
DR   SMR; O83246; -.
DR   IntAct; O83246; 2.
DR   STRING; 243276.TPANIC_0216; -.
DR   PRIDE; O83246; -.
DR   EnsemblBacteria; AAC65204; AAC65204; TP_0216.
DR   GeneID; 57878754; -.
DR   KEGG; tpa:TP_0216; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_12; -.
DR   OMA; ISIKRHM; -.
DR   OrthoDB; 161217at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Stress response.
FT   CHAIN           1..635
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078577"
FT   REGION          601..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         197
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   635 AA;  68042 MW;  11244A863A4504CD CRC64;
     MGKIIGIDLG TTNSCVAIME GGEPVVIQNA EGGRTTPSII GFTSDGGRVV GQPAKNQMVT
     NPEHTIYSIK RFIGSRFNEL TGEAKKVPYK IVPQGDDVRV EVEGKLYSTQ EISAFILQKM
     KKTAEDYLGE AVTEAVITVP AYFNDAQRQA TKDAGKIAGL DVKRIINEPT AASLAFGFNK
     DSKREKIIAV YDLGGGTFDI SILELGDGVF EVKSTNGDTH LGGDDFDARI VQWLEQGFKS
     DTGIDLGNDR MALQRLREAA EKAKIALSSS ASTEINLPFI TADANGPKHL QRTLSRSEFE
     KMTDDLFERT KEPCRKALKD AGISADRIDE ILLVGGSTRM PKVAHVIKDV FGKEGSKGVN
     PDEAVAIGAA IQGGILGGDV KDVLLLDVTP LSLGIETMGG VFTPLISRNT TIPTRKSQVF
     STAADGQTAV SIHVLQGERG MANQNRTLGN FDLVGIPPAP RGVPQIEVTF DIDANGIVHV
     SAKDLGTGKE QHIRIESSSG LSESEIDRMV KEAEANAESD KREREKIEAR NVADSLIYQT
     EKTLKEAGDG VNAADRARID EAIAELKTVL SGDDVASIKA KTEILQQASY KIAEEMYKRQ
     AAAGAAAGKK SDAPSGNEAE GGDVDYEVVK DEDSK