ID   DNAK_TROW8              Reviewed;         603 AA.
AC   P64410; Q83MQ0; Q83N74;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=TW762;
OS   Tropheryma whipplei (strain TW08/27) (Whipple's bacillus).
OC   Bacteria; Actinobacteria; Micrococcales; Tropherymataceae; Tropheryma.
OX   NCBI_TaxID=218496;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW08/27;
RX   PubMed=12606174; DOI=10.1016/s0140-6736(03)12597-4;
RA   Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G.,
RA   Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A.,
RA   Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J.,
RA   Relman D.A.;
RT   "Sequencing and analysis of the genome of the Whipple's disease bacterium
RT   Tropheryma whipplei.";
RL   Lancet 361:637-644(2003).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; BX251412; CAD67421.1; -; Genomic_DNA.
DR   RefSeq; WP_011096699.1; NC_004551.1.
DR   AlphaFoldDB; P64410; -.
DR   SMR; P64410; -.
DR   PRIDE; P64410; -.
DR   GeneID; 67388543; -.
DR   KEGG; tws:TW762; -.
DR   HOGENOM; CLU_005965_2_1_11; -.
DR   OMA; ISIKRHM; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 2.
DR   Pfam; PF00012; HSP70; 2.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Stress response.
FT   CHAIN           1..603
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_0000078579"
FT   REGION          578..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        579..603
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         175
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   603 AA;  65409 MW;  1F413797D7AB9C0F CRC64;
     MSRAVGIDLG TTNSVVAVLE GGEPNVIANA EGLRTTPSVV AFSRDGEVLV GDTAKRQAVT
     NVDNTISSVK RHIGTDWTKQ IGDKKYTPQE ISARILSKLK RDAEQYLGEK VTDAVITVPA
     YFNDAERQAT KEAGEIAGLN VLRIINEPTA AALAYGLDKG KEDELILVFD LGGGTFDVSL
     LEVGKDDDFS TIQVRATSGD NRLGGDDWDQ RIIDWLVDDF RKTTGVDLSS DKIAMQRLRE
     ASEQAKKELS SATSANIQLP YISLTESGPV NMDTTITRAQ FEKMTEDLLE RTKNPFRDVL
     KEAGVSVDKI SHVVLVGGST RMPAVSDLVK RETGKEPNKG VNPDEVVAVG AALQAGVLRG
     ERKDVLLIDV TPLSLGIETK GGIMTKLIER NTAIPTKRSE VFTTAEDNQP SVSIQVFQGE
     RELTQDNKNL GTFELTGIAP APRGLPQIEV TFDIDANGIV HVSAKDKGTG KEQSMTITGG
     SGLSQDEIDR MIKEAEEHAA EDKNRRARVD QKNQAEQMVY TAEKLIGDNA KVNEEAKKEL
     QADIDSLKSA IQADDHDLIK AGTDKLLASQ QKFAQSVYET TKDDPKEQVV DAEVVDEDSG
     SSK