ID   DNAK_WOLWR              Reviewed;         640 AA.
AC   C0R3W7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Chaperone protein DnaK {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=HSP70 {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock 70 kDa protein {ECO:0000255|HAMAP-Rule:MF_00332};
DE   AltName: Full=Heat shock protein 70 {ECO:0000255|HAMAP-Rule:MF_00332};
GN   Name=dnaK {ECO:0000255|HAMAP-Rule:MF_00332}; OrderedLocusNames=WRi_008800;
OS   Wolbachia sp. subsp. Drosophila simulans (strain wRi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Wolbachieae; Wolbachia; unclassified Wolbachia.
OX   NCBI_TaxID=66084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=wRi;
RX   PubMed=19307581; DOI=10.1073/pnas.0810753106;
RA   Klasson L., Westberg J., Sapountzis P., Naeslund K., Lutnaes Y.,
RA   Darby A.C., Veneti Z., Chen L., Braig H.R., Garrett R., Bourtzis K.,
RA   Andersson S.G.;
RT   "The mosaic genome structure of the Wolbachia wRi strain infecting
RT   Drosophila simulans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:5725-5730(2009).
CC   -!- FUNCTION: Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.
CC   -!- INDUCTION: By stress conditions e.g. heat shock. {ECO:0000255|HAMAP-
CC       Rule:MF_00332}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000255|HAMAP-Rule:MF_00332}.
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DR   EMBL; CP001391; ACN95609.1; -; Genomic_DNA.
DR   RefSeq; WP_012673300.1; NZ_MKIF01000055.1.
DR   AlphaFoldDB; C0R3W7; -.
DR   SMR; C0R3W7; -.
DR   STRING; 66084.WRi_008800; -.
DR   PRIDE; C0R3W7; -.
DR   EnsemblBacteria; ACN95609; ACN95609; WRi_008800.
DR   KEGG; wri:WRi_008800; -.
DR   HOGENOM; CLU_005965_2_1_5; -.
DR   OMA; ISIKRHM; -.
DR   Proteomes; UP000001293; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00332; DnaK; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR012725; Chaperone_DnaK.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR02350; prok_dnaK; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Phosphoprotein;
KW   Stress response.
FT   CHAIN           1..640
FT                   /note="Chaperone protein DnaK"
FT                   /id="PRO_1000133172"
FT   REGION          537..556
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          599..640
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        599..615
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        616..640
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         197
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00332"
SQ   SEQUENCE   640 AA;  69391 MW;  0DC0273B0787AA0C CRC64;
     MGRAIGIDLG TTNSCVAIMQ GKDTKVIENK EGARTTPSIV ALTSSGERLI GAPAKRQATT
     NASNTFFATK RLIGRQYSDP EMKNLSVPYK VFAAKSGDAW VKTTDNKEYS PSQIGAFILQ
     NMKEAAEAYL GEEVKDAVIT VPAYFNDSQR QATKDAGKIA GLNVLRIVNE PTAAALAYGL
     DKKHGHTIVV YDLGGGTFDV SILEIGDGVF EVKATNGDTH LGGEDFDNGV VSYLLDEFKK
     SNGIDLKNDP MAMQRIKEAA EKAKIELSSA METEINLPFI TADASGPKHL NMKLTRAKLE
     SLVNDLIERT MAPCKKALED AGLSASQIGE VVLVGGMTRM PKVIEKVKEF FGKDPHRGVN
     PDEVVAIGAA IQAGIIQGDV RDVLLLDVTP LSLGIETLGG VFTPLIERNT TIPTKKSQVF
     STAEDNQTAV TIKVHQGERK LAVDNKLLGQ FSLEGIPPAP RGRPQIEVTF DIDANGIAHV
     SAKDKATGKE QKIRIQSSGG LSDDEINRMV KEAEEKAQED EKRKKFIEVK NQADSLVHST
     EKSLTEYGDK VSPEDRSAIE NAVNELKEVS KSDNIDDADS IQQKVTNLSQ LSMKLGEAMY
     QASQQNSAEN GFSSEGNPND KEEKVVDSDY QDIDNKEENK