ID   DNAL1_BOVIN             Reviewed;         190 AA.
AC   Q2KID4;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Dynein axonemal light chain 1;
GN   Name=DNAL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the multisubunit axonemal ATPase complexes that
CC       generate the force for cilia motility and govern beat frequency (By
CC       similarity). Component of the outer arm dynein (ODA). May be involved
CC       in a mechanosensory feedback mechanism controlling ODA activity based
CC       on external conformational cues by tethering the outer arm dynein heavy
CC       chain (DNAH5) to the microtubule within the axoneme (By similarity).
CC       Important for ciliary function in the airways and for the function of
CC       the cilia that produce the nodal flow essential for the determination
CC       of the left-right asymmetry (By similarity).
CC       {ECO:0000250|UniProtKB:Q4LDG9, ECO:0000250|UniProtKB:Q9XHH2}.
CC   -!- SUBUNIT: Interacts with ZMYND10 (via C-terminus). Interacts with DNAH5,
CC       a outer arm dynein heavy chain. Interacts with tubulin located within
CC       the A-tubule of the outer doublets in a ATP-independent manner.
CC       {ECO:0000250|UniProtKB:Q4LDG9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q4LDG9}.
CC   -!- MISCELLANEOUS: Outer (ODAs) and inner (IDAs) dynein arms contain the
CC       molecular motors that generate the force to move cilia by ATP-dependent
CC       reactions. There are two mechanosensory systems that monitor and
CC       respond to the mechanical state (curvature) of the axoneme. One system
CC       involves the central pair microtubule complex and radial spokes and the
CC       second system involves the outer dynein arms.
CC       {ECO:0000250|UniProtKB:Q9XHH2}.
CC   -!- SIMILARITY: Belongs to the dynein light chain LC1-type family.
CC       {ECO:0000305}.
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DR   EMBL; BC112679; AAI12680.1; -; mRNA.
DR   RefSeq; NP_001039892.1; NM_001046427.2.
DR   RefSeq; XP_015328729.1; XM_015473243.1.
DR   AlphaFoldDB; Q2KID4; -.
DR   SMR; Q2KID4; -.
DR   STRING; 9913.ENSBTAP00000021183; -.
DR   PaxDb; Q2KID4; -.
DR   PRIDE; Q2KID4; -.
DR   Ensembl; ENSBTAT00000021183; ENSBTAP00000021183; ENSBTAG00000015930.
DR   GeneID; 538164; -.
DR   KEGG; bta:538164; -.
DR   CTD; 83544; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015930; -.
DR   VGNC; VGNC:55111; DNAL1.
DR   eggNOG; KOG0531; Eukaryota.
DR   GeneTree; ENSGT01010000222336; -.
DR   HOGENOM; CLU_092189_0_0_1; -.
DR   InParanoid; Q2KID4; -.
DR   OrthoDB; 1395642at2759; -.
DR   TreeFam; TF323974; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000015930; Expressed in cortex of kidney and 111 other tissues.
DR   ExpressionAtlas; Q2KID4; baseline.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0043014; F:alpha-tubulin binding; IBA:GO_Central.
DR   GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central.
DR   GO; GO:0036158; P:outer dynein arm assembly; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell projection; Cytoplasm; Cytoskeleton; Dynein;
KW   Leucine-rich repeat; Microtubule; Motor protein; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q4LDG9"
FT   CHAIN           2..190
FT                   /note="Dynein axonemal light chain 1"
FT                   /id="PRO_0000281129"
FT   REPEAT          49..70
FT                   /note="LRR 1"
FT   REPEAT          71..92
FT                   /note="LRR 2"
FT   REPEAT          94..115
FT                   /note="LRR 3"
FT   REPEAT          116..137
FT                   /note="LRR 4"
FT   DOMAIN          150..190
FT                   /note="LRRCT"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4LDG9"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05A62"
SQ   SEQUENCE   190 AA;  21536 MW;  956E6006EF73EAD5 CRC64;
     MAKATTIKEA LARWEEKTSQ KPSEAREIKL YAQIPPIEKM DASLSTLSNC EKLSLSTNCI
     EKIANLNGLK NLRILSLGRN NIKNLNGLEA VGDTLEELWI SYNFIEKLKG IHVMKKLKIL
     YMSNNLVKDW AEFVKLAELP CLEDLVFVGN PLEEKHSAEG NWVEEATKRV PKLKKLDGTP
     VIKEDEEEDN