DNAL1_DANRE
ID DNAL1_DANRE Reviewed; 192 AA.
AC Q6DHB1;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Dynein axonemal light chain 1;
GN Name=dnal1; ORFNames=zgc:92542;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the multisubunit axonemal ATPase complexes that
CC generate the force for cilia motility and govern beat frequency (By
CC similarity). Component of the outer arm dynein (ODA). May be involved
CC in a mechanosensory feedback mechanism controlling ODA activity based
CC on external conformational cues by tethering the outer arm dynein heavy
CC chain (DNAH5) to the microtubule within the axoneme (By similarity).
CC {ECO:0000250|UniProtKB:Q4LDG9, ECO:0000250|UniProtKB:Q9XHH2}.
CC -!- SUBUNIT: Interacts with DNAH5, a outer arm dynein heavy chain.
CC Interacts with tubulin located within the A-tubule of the outer
CC doublets in a ATP-independent manner. {ECO:0000250|UniProtKB:Q4LDG9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q4LDG9}.
CC -!- MISCELLANEOUS: Outer (ODAs) and inner (IDAs) dynein arms contain the
CC molecular motors that generate the force to move cilia by ATP-dependent
CC reactions. There are two mechanosensory systems that monitor and
CC respond to the mechanical state (curvature) of the axoneme. One system
CC involves the central pair microtubule complex and radial spokes and the
CC second system involves the outer dynein arms.
CC {ECO:0000250|UniProtKB:Q9XHH2}.
CC -!- SIMILARITY: Belongs to the dynein light chain LC1-type family.
CC {ECO:0000305}.
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DR EMBL; BC076064; AAH76064.1; -; mRNA.
DR RefSeq; NP_001003442.1; NM_001003442.1.
DR AlphaFoldDB; Q6DHB1; -.
DR SMR; Q6DHB1; -.
DR STRING; 7955.ENSDARP00000043650; -.
DR PaxDb; Q6DHB1; -.
DR Ensembl; ENSDART00000043651; ENSDARP00000043650; ENSDARG00000034042.
DR Ensembl; ENSDART00000188500; ENSDARP00000145599; ENSDARG00000097505.
DR GeneID; 445048; -.
DR KEGG; dre:445048; -.
DR CTD; 83544; -.
DR ZFIN; ZDB-GENE-040801-178; dnal1.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00390000016904; -.
DR HOGENOM; CLU_092189_0_0_1; -.
DR InParanoid; Q6DHB1; -.
DR OMA; EWNEFAR; -.
DR OrthoDB; 1395642at2759; -.
DR PhylomeDB; Q6DHB1; -.
DR PRO; PR:Q6DHB1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 17.
DR Bgee; ENSDARG00000034042; Expressed in testis and 19 other tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043014; F:alpha-tubulin binding; IBA:GO_Central.
DR GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central.
DR GO; GO:0036158; P:outer dynein arm assembly; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasm; Cytoskeleton; Dynein; Leucine-rich repeat;
KW Microtubule; Motor protein; Reference proteome; Repeat.
FT CHAIN 1..192
FT /note="Dynein axonemal light chain 1"
FT /id="PRO_0000281132"
FT REPEAT 49..70
FT /note="LRR 1"
FT REPEAT 71..92
FT /note="LRR 2"
FT REPEAT 94..115
FT /note="LRR 3"
FT REPEAT 116..137
FT /note="LRR 4"
FT DOMAIN 150..192
FT /note="LRRCT"
SQ SEQUENCE 192 AA; 21495 MW; 727E222218998E3E CRC64;
MAKATTIKEA LVKWEEKTGE KANDATAVKL YGQIPPIEKM DASLSNLVNC ERLSLSTNCI
EKIANLNGLK NLKILSLGRN NIKNLNGLEA VGDTLEELWI SYNLIEKLKG IHVMKKLKVL
YMSNNLVKEW GEFLKLADLP SLVDLVFVGN PLEEKYSADG NWIEEATKRL PKLKKLDGNP
VIKQEEETEG ES