ID   DNAL1_XENLA             Reviewed;         192 AA.
AC   Q641R9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Dynein axonemal light chain 1;
GN   Name=dnal1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the multisubunit axonemal ATPase complexes that
CC       generate the force for cilia motility and govern beat frequency (By
CC       similarity). Component of the outer arm dynein (ODA). May be involved
CC       in a mechanosensory feedback mechanism controlling ODA activity based
CC       on external conformational cues by tethering the outer arm dynein heavy
CC       chain (DNAH5) to the microtubule within the axoneme (By similarity).
CC       {ECO:0000250|UniProtKB:Q4LDG9, ECO:0000250|UniProtKB:Q9XHH2}.
CC   -!- SUBUNIT: Interacts with DNAH5, a outer arm dynein heavy chain.
CC       Interacts with tubulin located within the A-tubule of the outer
CC       doublets in a ATP-independent manner. {ECO:0000250|UniProtKB:Q4LDG9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q4LDG9}.
CC   -!- MISCELLANEOUS: Outer (ODAs) and inner (IDAs) dynein arms contain the
CC       molecular motors that generate the force to move cilia by ATP-dependent
CC       reactions. There are two mechanosensory systems that monitor and
CC       respond to the mechanical state (curvature) of the axoneme. One system
CC       involves the central pair microtubule complex and radial spokes and the
CC       second system involves the outer dynein arms.
CC       {ECO:0000250|UniProtKB:Q9XHH2}.
CC   -!- SIMILARITY: Belongs to the dynein light chain LC1-type family.
CC       {ECO:0000305}.
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DR   EMBL; BC082218; AAH82218.1; -; mRNA.
DR   RefSeq; NP_001087953.1; NM_001094484.1.
DR   AlphaFoldDB; Q641R9; -.
DR   SMR; Q641R9; -.
DR   MaxQB; Q641R9; -.
DR   PRIDE; Q641R9; -.
DR   DNASU; 494635; -.
DR   GeneID; 494635; -.
DR   KEGG; xla:494635; -.
DR   CTD; 494635; -.
DR   Xenbase; XB-GENE-983797; dnal1.L.
DR   OMA; LWISYNN; -.
DR   OrthoDB; 1395642at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 494635; Expressed in camera-type eye and 15 other tissues.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Dynein; Leucine-rich repeat;
KW   Microtubule; Motor protein; Reference proteome; Repeat.
FT   CHAIN           1..192
FT                   /note="Dynein axonemal light chain 1"
FT                   /id="PRO_0000281133"
FT   REPEAT          49..70
FT                   /note="LRR 1"
FT   REPEAT          71..92
FT                   /note="LRR 2"
FT   REPEAT          94..115
FT                   /note="LRR 3"
FT   REPEAT          116..137
FT                   /note="LRR 4"
FT   DOMAIN          150..192
FT                   /note="LRRCT"
SQ   SEQUENCE   192 AA;  21562 MW;  29A37B357B2F1513 CRC64;
     MAKATTIKEA LAKWEERTGQ KAGEAKEVKL YAQIPPLEKM DASLSTLVNC EKLSLSTNCI
     EKIANLNGLK YLKILSLGRN NIKNLNGLEA VGETLEELWI SYNLIEKLKG IHVMKKLKVL
     YMSNNLVKDW AEFSKLGELP LLGDIVFVGN PLEEKHTAEG NWMEEAVKRL PKLKKLDGNP
     VIKQEEEEGD ES