ID   DNAL4_MOUSE             Reviewed;         105 AA.
AC   Q9DCM4; O54793; Q3V233; Q99K65;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Dynein axonemal light chain 4;
GN   Name=Dnal4; Synonyms=Dnalc4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ogawa K.;
RT   "Identification of mouse outer arm dynein light chain 4.";
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head, and Kidney;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Force generating protein of respiratory cilia. Produces force
CC       towards the minus ends of microtubules. Dynein has ATPase activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC       intermediate and light chains.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dynein light chain family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK002657; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB010031; BAA24153.1; -; mRNA.
DR   EMBL; AK002657; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK132061; BAE20966.1; -; mRNA.
DR   EMBL; BC005426; AAH05426.1; -; mRNA.
DR   CCDS; CCDS27650.1; -.
DR   RefSeq; NP_059498.2; NM_017470.2.
DR   RefSeq; XP_006521233.1; XM_006521170.2.
DR   AlphaFoldDB; Q9DCM4; -.
DR   SMR; Q9DCM4; -.
DR   STRING; 10090.ENSMUSP00000023055; -.
DR   PhosphoSitePlus; Q9DCM4; -.
DR   MaxQB; Q9DCM4; -.
DR   PaxDb; Q9DCM4; -.
DR   PRIDE; Q9DCM4; -.
DR   ProteomicsDB; 279455; -.
DR   DNASU; 54152; -.
DR   Ensembl; ENSMUST00000023055; ENSMUSP00000023055; ENSMUSG00000022420.
DR   Ensembl; ENSMUST00000162713; ENSMUSP00000154848; ENSMUSG00000022420.
DR   GeneID; 54152; -.
DR   KEGG; mmu:54152; -.
DR   UCSC; uc007wuj.2; mouse.
DR   CTD; 10126; -.
DR   MGI; MGI:1859217; Dnal4.
DR   VEuPathDB; HostDB:ENSMUSG00000022420; -.
DR   eggNOG; KOG3430; Eukaryota.
DR   GeneTree; ENSGT00940000166105; -.
DR   HOGENOM; CLU_070944_3_0_1; -.
DR   InParanoid; Q9DCM4; -.
DR   OMA; YMFFGGN; -.
DR   OrthoDB; 1520814at2759; -.
DR   TreeFam; TF324136; -.
DR   Reactome; R-MMU-177504; Retrograde neurotrophin signalling.
DR   BioGRID-ORCS; 54152; 3 hits in 70 CRISPR screens.
DR   ChiTaRS; Dnal4; mouse.
DR   PRO; PR:Q9DCM4; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q9DCM4; protein.
DR   Bgee; ENSMUSG00000022420; Expressed in spermatid and 222 other tissues.
DR   ExpressionAtlas; Q9DCM4; baseline and differential.
DR   Genevisible; Q9DCM4; MM.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   Gene3D; 3.30.740.10; -; 1.
DR   InterPro; IPR037177; DLC_sf.
DR   InterPro; IPR001372; Dynein_light_chain_typ-1/2.
DR   PANTHER; PTHR11886; PTHR11886; 1.
DR   Pfam; PF01221; Dynein_light; 1.
DR   SMART; SM01375; Dynein_light; 1.
DR   SUPFAM; SSF54648; SSF54648; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Dynein; Microtubule;
KW   Motor protein; Reference proteome.
FT   CHAIN           1..105
FT                   /note="Dynein axonemal light chain 4"
FT                   /id="PRO_0000195137"
FT   CONFLICT        49
FT                   /note="N -> Y (in Ref. 1; AK002657)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        80
FT                   /note="E -> G (in Ref. 1; AK002657)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   105 AA;  12023 MW;  D1043882C40306B6 CRC64;
     MGETEGKKEE ADYKRLQTFP LVRHSDMPEE MRVETMELCV TACEKFSNNN ESAAKMIKET
     MDKKFGSSWH VVIGEGFGFE ITHEVKNLLY LYFGGTLAVC VWKCS