DNCH_MICAN
ID DNCH_MICAN Reviewed; 138 AA.
AC B0JQL4;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=1,4-dihydroxy-2-naphthoyl-CoA hydrolase {ECO:0000255|HAMAP-Rule:MF_02101};
DE Short=DHNA-CoA hydrolase {ECO:0000255|HAMAP-Rule:MF_02101};
DE EC=3.1.2.28 {ECO:0000255|HAMAP-Rule:MF_02101};
DE AltName: Full=DHNA-CoA thioesterase {ECO:0000255|HAMAP-Rule:MF_02101};
GN OrderedLocusNames=MAE_08510;
OS Microcystis aeruginosa (strain NIES-843 / IAM M-2473).
OC Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC Microcystaceae; Microcystis.
OX NCBI_TaxID=449447;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-843 / IAM M-247;
RX PubMed=18192279; DOI=10.1093/dnares/dsm026;
RA Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M.,
RA Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A.,
RA Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M.,
RA Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M.;
RT "Complete genomic structure of the bloom-forming toxic cyanobacterium
RT Microcystis aeruginosa NIES-843.";
RL DNA Res. 14:247-256(2007).
CC -!- FUNCTION: Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA
CC (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in
CC phylloquinone (vitamin K1) biosynthesis. {ECO:0000255|HAMAP-
CC Rule:MF_02101}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-
CC naphthoate + CoA + H(+); Xref=Rhea:RHEA:26309, ChEBI:CHEBI:11173,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:58897; EC=3.1.2.28; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_02101};
CC -!- PATHWAY: Cofactor biosynthesis; phylloquinone biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_02101}.
CC -!- PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate
CC biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7.
CC {ECO:0000255|HAMAP-Rule:MF_02101}.
CC -!- SIMILARITY: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.
CC DHNA-CoA hydrolase subfamily. {ECO:0000255|HAMAP-Rule:MF_02101}.
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DR EMBL; AP009552; BAG00673.1; -; Genomic_DNA.
DR RefSeq; WP_012264388.1; NC_010296.1.
DR AlphaFoldDB; B0JQL4; -.
DR SMR; B0JQL4; -.
DR STRING; 449447.MAE_08510; -.
DR PaxDb; B0JQL4; -.
DR EnsemblBacteria; BAG00673; BAG00673; MAE_08510.
DR KEGG; mar:MAE_08510; -.
DR PATRIC; fig|449447.4.peg.790; -.
DR eggNOG; COG0824; Bacteria.
DR HOGENOM; CLU_101141_5_3_3; -.
DR OMA; IVNCEAN; -.
DR OrthoDB; 1786865at2; -.
DR BioCyc; MAER449447:MAE_RS03785-MON; -.
DR UniPathway; UPA00995; -.
DR UniPathway; UPA01057; UER01033.
DR Proteomes; UP000001510; Chromosome.
DR GO; GO:0016790; F:thiolester hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042372; P:phylloquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_02101; DHNA_CoA_hydrolase; 1.
DR InterPro; IPR022829; DHNA_CoA_hydrolase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR006684; YbgC/YbaW.
DR PIRSF; PIRSF003230; YbgC; 1.
DR SUPFAM; SSF54637; SSF54637; 1.
PE 3: Inferred from homology;
KW Hydrolase; Reference proteome.
FT CHAIN 1..138
FT /note="1,4-dihydroxy-2-naphthoyl-CoA hydrolase"
FT /id="PRO_0000377013"
FT ACT_SITE 13
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02101"
SQ SEQUENCE 138 AA; 15877 MW; 2C4A8917DBBD9DAB CRC64;
MPYERLIYLA DTDAAGVVYF AHLLSICHEA YEFSLAQFGI NIKDFFKDSP VALPITQAEI
QFFRPLFCGD RIQIDFTVRS LSENEFQLQY KIYLAEIMVA KAKTRHVCIA PTARKRIPLP
ESLKHWLGYL STLEETGI
