ID   DNCH_PROMT              Reviewed;         155 AA.
AC   Q46HJ9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=1,4-dihydroxy-2-naphthoyl-CoA hydrolase {ECO:0000255|HAMAP-Rule:MF_02101};
DE            Short=DHNA-CoA hydrolase {ECO:0000255|HAMAP-Rule:MF_02101};
DE            EC=3.1.2.28 {ECO:0000255|HAMAP-Rule:MF_02101};
DE   AltName: Full=DHNA-CoA thioesterase {ECO:0000255|HAMAP-Rule:MF_02101};
GN   OrderedLocusNames=PMN2A_1541;
OS   Prochlorococcus marinus (strain NATL2A).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL2A;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA
CC       (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in
CC       phylloquinone (vitamin K1) biosynthesis. {ECO:0000255|HAMAP-
CC       Rule:MF_02101}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-
CC         naphthoate + CoA + H(+); Xref=Rhea:RHEA:26309, ChEBI:CHEBI:11173,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58897; EC=3.1.2.28; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_02101};
CC   -!- PATHWAY: Cofactor biosynthesis; phylloquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_02101}.
CC   -!- PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate
CC       biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7.
CC       {ECO:0000255|HAMAP-Rule:MF_02101}.
CC   -!- SIMILARITY: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.
CC       DHNA-CoA hydrolase subfamily. {ECO:0000255|HAMAP-Rule:MF_02101}.
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DR   EMBL; CP000095; AAZ59029.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q46HJ9; -.
DR   SMR; Q46HJ9; -.
DR   STRING; 59920.PMN2A_1541; -.
DR   EnsemblBacteria; AAZ59029; AAZ59029; PMN2A_1541.
DR   KEGG; pmn:PMN2A_1541; -.
DR   HOGENOM; CLU_101141_5_3_3; -.
DR   OMA; IVNCEAN; -.
DR   PhylomeDB; Q46HJ9; -.
DR   UniPathway; UPA00995; -.
DR   UniPathway; UPA01057; UER01033.
DR   Proteomes; UP000002535; Chromosome.
DR   GO; GO:0016790; F:thiolester hydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042372; P:phylloquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02101; DHNA_CoA_hydrolase; 1.
DR   InterPro; IPR022829; DHNA_CoA_hydrolase.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR006683; Thioestr_dom.
DR   Pfam; PF03061; 4HBT; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..155
FT                   /note="1,4-dihydroxy-2-naphthoyl-CoA hydrolase"
FT                   /id="PRO_0000377025"
FT   ACT_SITE        27
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02101"
SQ   SEQUENCE   155 AA;  18133 MW;  68B8FF0B5446086F CRC64;
     MIDRFLDKRN PREWLCLKRT VRFGETDAAG VVHFLELFRW CHETWEESLE KYGIALKDIF
     PTNEINTSQL DIALPVVHCE ANYFQPLYVG DTINIELETE KINESSFVLR FKFKKNGEQI
     GSTNIKHVSI NPITRKKCAL SKQINLWLHE SSSNF