DND1_HUMAN
ID DND1_HUMAN Reviewed; 353 AA.
AC Q8IYX4;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Dead end protein homolog 1;
DE AltName: Full=RNA-binding motif, single-stranded-interacting protein 4;
GN Name=DND1; Synonyms=RBMS4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12932328; DOI=10.1016/s0960-9822(03)00537-2;
RA Weidinger G., Stebler J., Slanchev K., Dumstrei K., Wise C.,
RA Lovell-Badge R., Thisse C., Thisse B., Raz E.;
RT "Dead end, a novel vertebrate germ plasm component, is required for
RT zebrafish primordial germ cell migration and survival.";
RL Curr. Biol. 13:1429-1434(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, RNA-BINDING, AND SUBCELLULAR LOCATION.
RX PubMed=18155131; DOI=10.1016/j.cell.2007.11.034;
RA Kedde M., Strasser M.J., Boldajipour B., Oude Vrielink J.A., Slanchev K.,
RA le Sage C., Nagel R., Voorhoeve P.M., van Duijse J., Oerom U.A., Lund A.H.,
RA Perrakis A., Raz E., Agami R.;
RT "RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.";
RL Cell 131:1273-1286(2007).
CC -!- FUNCTION: RNA-binding factor that positively regulates gene expression
CC by prohibiting miRNA-mediated gene suppression. Relieves miRNA
CC repression in germline cells (By similarity). Prohibits the function of
CC several miRNAs by blocking the accessibility of target mRNAs. Sequence-
CC specific RNA-binding factor that binds specifically to U-rich regions
CC (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does
CC not bind to miRNAs. May play a role during primordial germ cell (PGC)
CC survival (By similarity). However, does not seem to be essential for
CC PGC migration (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:18155131}.
CC -!- SUBUNIT: Interacts with APOBEC3. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8IYX4; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-12071340, EBI-11987469;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18155131}. Cytoplasm
CC {ECO:0000269|PubMed:18155131}. Note=Perinuclear germ granules, also
CC called germ plasm or chromatoid body. Colocalizes in perinuclear sites
CC with APOBEC3 (By similarity). {ECO:0000250}.
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DR EMBL; AY321065; AAQ63635.1; -; mRNA.
DR EMBL; BC033496; AAH33496.1; -; mRNA.
DR CCDS; CCDS4236.1; -.
DR RefSeq; NP_919225.1; NM_194249.2.
DR PDB; 6LE1; X-ray; 2.30 A; A=139-217.
DR PDBsum; 6LE1; -.
DR AlphaFoldDB; Q8IYX4; -.
DR SMR; Q8IYX4; -.
DR BioGRID; 131887; 19.
DR IntAct; Q8IYX4; 8.
DR STRING; 9606.ENSP00000445366; -.
DR iPTMnet; Q8IYX4; -.
DR PhosphoSitePlus; Q8IYX4; -.
DR BioMuta; DND1; -.
DR DMDM; 60389799; -.
DR EPD; Q8IYX4; -.
DR MassIVE; Q8IYX4; -.
DR PaxDb; Q8IYX4; -.
DR PeptideAtlas; Q8IYX4; -.
DR PRIDE; Q8IYX4; -.
DR ProteomicsDB; 71258; -.
DR Antibodypedia; 49888; 228 antibodies from 23 providers.
DR DNASU; 373863; -.
DR Ensembl; ENST00000542735.2; ENSP00000445366.1; ENSG00000256453.2.
DR GeneID; 373863; -.
DR KEGG; hsa:373863; -.
DR MANE-Select; ENST00000542735.2; ENSP00000445366.1; NM_194249.3; NP_919225.1.
DR UCSC; uc003lgt.4; human.
DR CTD; 373863; -.
DR DisGeNET; 373863; -.
DR GeneCards; DND1; -.
DR HGNC; HGNC:23799; DND1.
DR HPA; ENSG00000256453; Tissue enhanced (testis).
DR MIM; 609385; gene.
DR neXtProt; NX_Q8IYX4; -.
DR OpenTargets; ENSG00000256453; -.
DR PharmGKB; PA134931157; -.
DR VEuPathDB; HostDB:ENSG00000256453; -.
DR eggNOG; KOG0117; Eukaryota.
DR GeneTree; ENSGT00940000159225; -.
DR HOGENOM; CLU_022960_0_0_1; -.
DR InParanoid; Q8IYX4; -.
DR OMA; QLWCERV; -.
DR OrthoDB; 1384330at2759; -.
DR PhylomeDB; Q8IYX4; -.
DR TreeFam; TF314932; -.
DR PathwayCommons; Q8IYX4; -.
DR SignaLink; Q8IYX4; -.
DR BioGRID-ORCS; 373863; 22 hits in 1062 CRISPR screens.
DR GenomeRNAi; 373863; -.
DR Pharos; Q8IYX4; Tbio.
DR PRO; PR:Q8IYX4; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8IYX4; protein.
DR Bgee; ENSG00000256453; Expressed in right testis and 82 other tissues.
DR Genevisible; Q8IYX4; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0061158; P:3'-UTR-mediated mRNA destabilization; IDA:CACAO.
DR GO; GO:0007281; P:germ cell development; IEA:Ensembl.
DR GO; GO:0048255; P:mRNA stabilization; IBA:GO_Central.
DR GO; GO:0060965; P:negative regulation of miRNA-mediated gene silencing; IDA:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd20313; DSRM_DND1; 1.
DR CDD; cd12487; RRM1_DND1; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR044448; DND1_DSRM.
DR InterPro; IPR034414; DND1_RRM1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Developmental protein; Nucleus;
KW Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..353
FT /note="Dead end protein homolog 1"
FT /id="PRO_0000081568"
FT DOMAIN 58..136
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 140..213
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT STRAND 139..145
FT /evidence="ECO:0007829|PDB:6LE1"
FT HELIX 151..158
FT /evidence="ECO:0007829|PDB:6LE1"
FT HELIX 159..161
FT /evidence="ECO:0007829|PDB:6LE1"
FT STRAND 165..172
FT /evidence="ECO:0007829|PDB:6LE1"
FT STRAND 174..177
FT /evidence="ECO:0007829|PDB:6LE1"
FT STRAND 180..188
FT /evidence="ECO:0007829|PDB:6LE1"
FT HELIX 189..205
FT /evidence="ECO:0007829|PDB:6LE1"
SQ SEQUENCE 353 AA; 38687 MW; 15014AA66BFD4F0F CRC64;
MQSKRDCELW CERVNPENKA ALEAWVRETG IRLVQVNGQR KYGGPPPGWV GSPPPAGSEV
FIGRLPQDVY EHQLIPLFQR VGRLYEFRLM MTFSGLNRGF AYARYSSRRG AQAAIATLHN
HPLRPSCPLL VCRSTEKCEL SVDGLPPNLT RSALLLALQP LGPGLQEARL LPSPGPAPGQ
IALLKFSSHR AAAMAKKALV EGQSHLCGEQ VAVEWLKPDL KQRLRQQLVG PFLRSPQPEG
SQLALARDKL GFQGARATLQ LLCQRMKLGS PVFLTKCLGI GPAGWHRFWY QVVIPGHPVP
FSGLIWVVLT LDGRDGHEVA KDAVSVRLLQ ALSESGANLL WSAGAEAGTM VKQ
