ID   DND1_XENLA              Reviewed;         371 AA.
AC   Q6DCB7; Q6VXX9;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Dead end protein homolog 1;
GN   Name=dnd1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 18-371.
RX   PubMed=12932328; DOI=10.1016/s0960-9822(03)00537-2;
RA   Weidinger G., Stebler J., Slanchev K., Dumstrei K., Wise C.,
RA   Lovell-Badge R., Thisse C., Thisse B., Raz E.;
RT   "Dead end, a novel vertebrate germ plasm component, is required for
RT   zebrafish primordial germ cell migration and survival.";
RL   Curr. Biol. 13:1429-1434(2003).
CC   -!- FUNCTION: RNA-binding factor that positively regulates gene expression
CC       by prohibiting miRNA-mediated gene suppression. Relieves miRNA
CC       repression in germline cells. Prohibits the function of several miRNAs
CC       by blocking the accessibility of target mRNAs. Sequence-specific RNA-
CC       binding factor that binds to U-rich regions (URRs) in the
CC       3'untranslated region (3'-UTR) of several mRNAs. Does not bind to
CC       miRNAs. May play a role during early embryonic survival (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Perinuclear germ granules, also called germ plasm or chromatoid
CC       body. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in germ cells; along the cleavage planes
CC       at the vegetal pole of early cleavage stage embryos.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH78132.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC078132; AAH78132.1; ALT_INIT; mRNA.
DR   EMBL; AY321494; AAQ63637.1; -; mRNA.
DR   AlphaFoldDB; Q6DCB7; -.
DR   SMR; Q6DCB7; -.
DR   IntAct; Q6DCB7; 1.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; ISS:UniProtKB.
DR   GO; GO:0007281; P:germ cell development; IEA:InterPro.
DR   GO; GO:0060965; P:negative regulation of miRNA-mediated gene silencing; ISS:UniProtKB.
DR   CDD; cd20313; DSRM_DND1; 1.
DR   CDD; cd12487; RRM1_DND1; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR044448; DND1_DSRM.
DR   InterPro; IPR034414; DND1_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..371
FT                   /note="Dead end protein homolog 1"
FT                   /id="PRO_0000081571"
FT   DOMAIN          85..163
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          165..245
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   CONFLICT        270
FT                   /note="K -> R (in Ref. 2; AAQ63637)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   371 AA;  41413 MW;  B6B0C0C75E8D4741 CRC64;
     MATSAAFLKG DFKRTGKMEL SDEQKSQMWI NSVNSENKEA LLAWVKETGI ELVQINGQRK
     YGGPPPGWIG NAPVSGSEVF IGKIPQDIYE DKLIPLFQSV GKLYEFRLMM TFSGLNRGFA
     YARYISRRQA ISAIMSLNGF EITKGCCIVV CRSTEKSELA LDGLPGNFDE NMLKNVLDEV
     TSGVSSISLH PSPTKESQVL AVVKYDSHRA AAMAKKTLCE GSPILPGLPL TVNWLKTDMR
     QKLRSTDKLQ QTKDLSPLPL LYTDRPDLPK ETLLSAVGCL NMLCQEMKLG RPVFLIKLFS
     VTSFGWIRFW YQVVIPTYPT PFCGYAWMIG ENLELNEKYE HARQVVAMKI LSALGYIPDF
     SLGDVTARNA L