DNER_HUMAN
ID DNER_HUMAN Reviewed; 737 AA.
AC Q8NFT8; A6NP39; Q53R88; Q53TP7; Q53TQ5; Q8IYT0; Q8TB42; Q9NTF1; Q9UDM2;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Delta and Notch-like epidermal growth factor-related receptor;
DE Flags: Precursor;
GN Name=DNER; Synonyms=BET; ORFNames=UNQ262/PRO299;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=11950833; DOI=10.1074/jbc.m110793200;
RA Eiraku M., Hirata Y., Takeshima H., Hirano T., Kengaku M.;
RT "Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel
RT EGF-like repeat-containing protein targeted to dendrites of developing and
RT adult central nervous system neurons.";
RL J. Biol. Chem. 277:25400-25407(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-433.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-737.
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=11997712; DOI=10.1097/00001756-200205070-00035;
RA Nishizumi H., Komiyama T., Miyabayashi T., Sakano S., Sakano H.;
RT "BET, a novel neuronal transmembrane protein with multiple EGF-like
RT motifs.";
RL NeuroReport 13:909-915(2002).
RN [8]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-223.
RC TISSUE=Saliva;
RX PubMed=16740002; DOI=10.1021/pr050492k;
RA Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.;
RT "Identification of N-linked glycoproteins in human saliva by glycoprotein
RT capture and mass spectrometry.";
RL J. Proteome Res. 5:1493-1503(2006).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- FUNCTION: Activator of the NOTCH1 pathway. May mediate neuron-glia
CC interaction during astrocytogenesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with AP1G1. Interacts with NOTCH1 (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q8NFT8; Q9NR12: PDLIM7; NbExp=3; IntAct=EBI-2682727, EBI-350517;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein. Note=Present on the membrane of dendrites and cell bodies but
CC excluded from axonal membrane. Also found in early endosomes in the
CC somatodendritic region (By similarity). {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, spinal cord and adrenal gland.
CC {ECO:0000269|PubMed:11997712}.
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DR EMBL; AF442487; AAM21557.1; -; mRNA.
DR EMBL; AY358891; AAQ89250.1; -; mRNA.
DR EMBL; AC007559; AAY14939.1; -; Genomic_DNA.
DR EMBL; AC007748; AAY24263.1; -; Genomic_DNA.
DR EMBL; AC008273; AAF19247.2; -; Genomic_DNA.
DR EMBL; AC093384; AAY14680.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70893.1; -; Genomic_DNA.
DR EMBL; BC024766; AAH24766.2; -; mRNA.
DR EMBL; BC035009; AAH35009.1; -; mRNA.
DR EMBL; AL137311; CAB70690.1; -; mRNA.
DR CCDS; CCDS33390.1; -.
DR PIR; T46247; T46247.
DR RefSeq; NP_620711.3; NM_139072.3.
DR AlphaFoldDB; Q8NFT8; -.
DR SMR; Q8NFT8; -.
DR BioGRID; 124973; 2.
DR DIP; DIP-46249N; -.
DR IntAct; Q8NFT8; 4.
DR STRING; 9606.ENSP00000345229; -.
DR GlyGen; Q8NFT8; 3 sites.
DR iPTMnet; Q8NFT8; -.
DR PhosphoSitePlus; Q8NFT8; -.
DR BioMuta; DNER; -.
DR DMDM; 74730301; -.
DR EPD; Q8NFT8; -.
DR jPOST; Q8NFT8; -.
DR MassIVE; Q8NFT8; -.
DR MaxQB; Q8NFT8; -.
DR PaxDb; Q8NFT8; -.
DR PeptideAtlas; Q8NFT8; -.
DR PRIDE; Q8NFT8; -.
DR ProteomicsDB; 73354; -.
DR Antibodypedia; 2715; 232 antibodies from 30 providers.
DR DNASU; 92737; -.
DR Ensembl; ENST00000341772.5; ENSP00000345229.4; ENSG00000187957.8.
DR GeneID; 92737; -.
DR KEGG; hsa:92737; -.
DR MANE-Select; ENST00000341772.5; ENSP00000345229.4; NM_139072.4; NP_620711.3.
DR UCSC; uc002vpv.4; human.
DR CTD; 92737; -.
DR DisGeNET; 92737; -.
DR GeneCards; DNER; -.
DR HGNC; HGNC:24456; DNER.
DR HPA; ENSG00000187957; Tissue enhanced (adrenal gland, brain, choroid plexus).
DR MIM; 607299; gene.
DR neXtProt; NX_Q8NFT8; -.
DR OpenTargets; ENSG00000187957; -.
DR PharmGKB; PA162383959; -.
DR VEuPathDB; HostDB:ENSG00000187957; -.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000158872; -.
DR HOGENOM; CLU_019513_0_0_1; -.
DR InParanoid; Q8NFT8; -.
DR OMA; LNGFTCQ; -.
DR OrthoDB; 7525at2759; -.
DR PhylomeDB; Q8NFT8; -.
DR TreeFam; TF351322; -.
DR PathwayCommons; Q8NFT8; -.
DR Reactome; R-HSA-2122948; Activated NOTCH1 Transmits Signal to the Nucleus.
DR SignaLink; Q8NFT8; -.
DR SIGNOR; Q8NFT8; -.
DR BioGRID-ORCS; 92737; 9 hits in 1071 CRISPR screens.
DR ChiTaRS; DNER; human.
DR GeneWiki; DNER; -.
DR GenomeRNAi; 92737; -.
DR Pharos; Q8NFT8; Tbio.
DR PRO; PR:Q8NFT8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8NFT8; protein.
DR Bgee; ENSG00000187957; Expressed in lateral nuclear group of thalamus and 148 other tissues.
DR Genevisible; Q8NFT8; HS.
DR GO; GO:0030425; C:dendrite; IDA:UniProtKB.
DR GO; GO:0005769; C:early endosome; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; NAS:UniProtKB.
DR GO; GO:0030276; F:clathrin binding; TAS:UniProtKB.
DR GO; GO:0005112; F:Notch binding; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:UniProtKB.
DR GO; GO:0007417; P:central nervous system development; IEP:UniProtKB.
DR GO; GO:0006897; P:endocytosis; NAS:UniProtKB.
DR GO; GO:0010001; P:glial cell differentiation; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; NAS:UniProtKB.
DR GO; GO:0007220; P:Notch receptor processing; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR GO; GO:0007416; P:synapse assembly; NAS:UniProtKB.
DR InterPro; IPR045769; DNER_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR Pfam; PF19330; DNER_C; 1.
DR Pfam; PF00008; EGF; 6.
DR Pfam; PF12661; hEGF; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SUPFAM; SSF57184; SSF57184; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 10.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 10.
DR PROSITE; PS01187; EGF_CA; 2.
PE 1: Evidence at protein level;
KW Activator; Calcium; Cell membrane; Disulfide bond; EGF-like domain;
KW Glycoprotein; Membrane; Notch signaling pathway; Phosphoprotein; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..737
FT /note="Delta and Notch-like epidermal growth factor-related
FT receptor"
FT /id="PRO_0000253557"
FT TOPO_DOM 35..640
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 641..661
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 662..737
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 44..92
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 94..133
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 309..348
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 349..390
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 392..428
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 430..466
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 468..503
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 505..541
FT /note="EGF-like 8; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 543..579
FT /note="EGF-like 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 546..568
FT /note="Follistatin-like"
FT DOMAIN 581..617
FT /note="EGF-like 10; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 44..133
FT /note="Interaction with NOTCH1"
FT /evidence="ECO:0000250"
FT REGION 677..680
FT /note="Interaction with AP1G1 and somatodendritic
FT targeting"
FT /evidence="ECO:0000250"
FT MOD_RES 685
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8JZM4"
FT MOD_RES 711
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q8JZM4"
FT MOD_RES 721
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q8JZM4"
FT MOD_RES 722
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8JZM4"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16740002"
FT CARBOHYD 564
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 48..59
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 53..80
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 82..91
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 98..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 103..121
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 123..132
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 319..336
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 338..347
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 353..364
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 358..378
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 380..389
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 396..407
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 401..416
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 418..427
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 434..445
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 439..454
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 456..465
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 472..482
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 477..491
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 493..502
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 509..520
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 514..529
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 531..540
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 547..558
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 552..567
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 569..578
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 585..596
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 590..605
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 607..616
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT VARIANT 433
FT /note="P -> L (in dbSNP:rs17853365)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_028380"
SQ SEQUENCE 737 AA; 78475 MW; 25A8A8A3044308BE CRC64;
MQPRRAQAPG AQLLPALALL LLLLGAGPRG SSLANPVPAA PLSAPGPCAA QPCRNGGVCT
SRPEPDPQHP APAGEPGYSC TCPAGISGAN CQLVADPCAS NPCHHGNCSS SSSSSSDGYL
CICNEGYEGP NCEQALPSLP ATGWTESMAP RQLQPVPATQ EPDKILPRSQ ATVTLPTWQP
KTGQKVVEMK WDQVEVIPDI ACGNASSNSS AGGRLVSFEV PQNTSVKIRQ DATASLILLW
KVTATGFQQC SLIDGRSVTP LQASGGLVLL EEMLALGNNH FIGFVNDSVT KSIVALRLTL
VVKVSTCVPG ESHANDLECS GKGKCTTKPS EATFSCTCEE QYVGTFCEEY DACQRKPCQN
NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP CRNGATCISS LSGFTCQCPE
GYFGSACEEK VDPCASSPCQ NNGTCYVDGV HFTCNCSPGF TGPTCAQLID FCALSPCAHG
TCRSVGTSYK CLCDPGYHGL YCEEEYNECL SAPCLNAATC RDLVNGYECV CLAEYKGTHC
ELYKDPCANV SCLNGATCDS DGLNGTCICA PGFTGEECDI DINECDSNPC HHGGSCLDQP
NGYNCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF ILMLIILIVG
ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA RFGKKSRPAM YDVSPIAYED
YSPDDKPLVT LIKTKDL
