ID   DNJ2_CAEEL              Reviewed;         337 AA.
AC   Q17433;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=DnaJ homolog dnj-2;
DE   AltName: Full=DnaJ domain protein 2;
GN   Name=dnj-2; ORFNames=B0035.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS) OF 23-129.
RG   Midwest center for structural genomics (MCSG);
RT   "X-ray crystal structure of j-domain of DNAj homolog dnj-2 precursor from
RT   c.elegans.";
RL   Submitted (AUG-2007) to the PDB data bank.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DNAJC25 family. {ECO:0000305}.
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DR   EMBL; Z73102; CAA97409.1; -; Genomic_DNA.
DR   PIR; T18654; T18654.
DR   RefSeq; NP_502126.1; NM_069725.4.
DR   PDB; 2QSA; X-ray; 1.68 A; A=24-129.
DR   PDBsum; 2QSA; -.
DR   AlphaFoldDB; Q17433; -.
DR   SMR; Q17433; -.
DR   BioGRID; 43142; 2.
DR   DIP; DIP-24486N; -.
DR   STRING; 6239.B0035.2; -.
DR   EPD; Q17433; -.
DR   PaxDb; Q17433; -.
DR   PeptideAtlas; Q17433; -.
DR   PRIDE; Q17433; -.
DR   EnsemblMetazoa; B0035.2.1; B0035.2.1; WBGene00001020.
DR   GeneID; 178043; -.
DR   KEGG; cel:CELE_B0035.2; -.
DR   UCSC; B0035.2; c. elegans.
DR   CTD; 178043; -.
DR   WormBase; B0035.2; CE05160; WBGene00001020; dnj-2.
DR   eggNOG; KOG0722; Eukaryota.
DR   GeneTree; ENSGT00970000196461; -.
DR   HOGENOM; CLU_055735_0_0_1; -.
DR   InParanoid; Q17433; -.
DR   OMA; IGKAYRQ; -.
DR   OrthoDB; 1332758at2759; -.
DR   PhylomeDB; Q17433; -.
DR   EvolutionaryTrace; Q17433; -.
DR   PRO; PR:Q17433; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00001020; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR044632; DNAJC25-like.
DR   InterPro; IPR036869; J_dom_sf.
DR   PANTHER; PTHR44176; PTHR44176; 1.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chaperone; Coiled coil; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..337
FT                   /note="DnaJ homolog dnj-2"
FT                   /id="PRO_0000007269"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          36..105
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   COILED          293..323
FT                   /evidence="ECO:0000255"
FT   TURN            31..34
FT                   /evidence="ECO:0007829|PDB:2QSA"
FT   HELIX           37..40
FT                   /evidence="ECO:0007829|PDB:2QSA"
FT   HELIX           45..47
FT                   /evidence="ECO:0007829|PDB:2QSA"
FT   HELIX           50..63
FT                   /evidence="ECO:0007829|PDB:2QSA"
FT   HELIX           66..68
FT                   /evidence="ECO:0007829|PDB:2QSA"
FT   HELIX           72..93
FT                   /evidence="ECO:0007829|PDB:2QSA"
FT   HELIX           95..106
FT                   /evidence="ECO:0007829|PDB:2QSA"
FT   HELIX           111..121
FT                   /evidence="ECO:0007829|PDB:2QSA"
SQ   SEQUENCE   337 AA;  39993 MW;  03CB56511FE0185D CRC64;
     MRSAIAAPIL FLLVSFFVQE CESVGFAPEL YCGLENCYDV LEVNREEFDK QKLAKAYRAL
     ARKHHPDRVK NKEEKLLAEE RFRVIATAYE TLKDDEAKTN YDYYLDHPDQ RFYNYYQYYR
     LRAAPKVDLR IVIVGTILII SLFQFLSAKH KFSEAIEYAT GVGKFRNMAI KDGIDKGLLE
     MDRNGKLKKN KGVDNDEVIK QIIIDNLDVT GGYKRESIYD TLAWHTIIFP LTIFRYIKWT
     ALWYWRFAIQ KEEYDDDAKL YLIRKYIGVS QMEFDQKYTD EDIDDLFERE CWLKRNCATW
     KAERDAAEQE KMAQSGRYKR YKRYMKNAGT ISFVDED