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DNJ5B_HUMAN
ID   DNJ5B_HUMAN             Reviewed;         199 AA.
AC   Q9UF47; Q969Y8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2002, sequence version 2.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=DnaJ homolog subfamily C member 5B;
DE   AltName: Full=Cysteine-string protein isoform beta {ECO:0000303|PubMed:17034881};
DE            Short=CSP-beta {ECO:0000303|PubMed:17034881};
GN   Name=DNAJC5B; Synonyms=CSPBETA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tobaben S., Stahl B.;
RT   "Novel isoforms of the cysteine string protein.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-44.
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   INTERACTION WITH HSC70 AND SGTA, SUBCELLULAR LOCATION, AND PALMITOYLATION.
RX   PubMed=17034881; DOI=10.1016/j.bbamcr.2006.08.054;
RA   Boal F., Le Pevelen S., Cziepluch C., Scotti P., Lang J.;
RT   "Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-
RT   Golgi network as a non-palmitoylated CSP in clonal beta-cells.";
RL   Biochim. Biophys. Acta 1773:109-119(2007).
CC   -!- SUBUNIT: Interacts with the chaperone complex consisting of HSC70 and
CC       SGTA. {ECO:0000269|PubMed:17034881}.
CC   -!- INTERACTION:
CC       Q9UF47; Q12800: TFCP2; NbExp=3; IntAct=EBI-10320535, EBI-717422;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17034881}; Lipid-
CC       anchor {ECO:0000269|PubMed:17034881}. Note=May be associated with the
CC       trans-Golgi network. {ECO:0000269|PubMed:17034881}.
CC   -!- TISSUE SPECIFICITY: Testis specific.
CC   -!- PTM: Palmitoylated. Palmitoylation is not required for membrane
CC       association. {ECO:0000269|PubMed:17034881}.
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DR   EMBL; AF368276; AAK60571.1; -; mRNA.
DR   EMBL; BC016742; AAH16742.1; -; mRNA.
DR   EMBL; AL133660; CAB63773.2; -; mRNA.
DR   CCDS; CCDS6183.1; -.
DR   PIR; T43470; T43470.
DR   RefSeq; NP_149096.2; NM_033105.4.
DR   RefSeq; XP_011515920.1; XM_011517618.2.
DR   AlphaFoldDB; Q9UF47; -.
DR   SMR; Q9UF47; -.
DR   BioGRID; 124554; 85.
DR   IntAct; Q9UF47; 1.
DR   STRING; 9606.ENSP00000276570; -.
DR   iPTMnet; Q9UF47; -.
DR   PhosphoSitePlus; Q9UF47; -.
DR   SwissPalm; Q9UF47; -.
DR   BioMuta; DNAJC5B; -.
DR   DMDM; 20141445; -.
DR   jPOST; Q9UF47; -.
DR   MassIVE; Q9UF47; -.
DR   PaxDb; Q9UF47; -.
DR   PeptideAtlas; Q9UF47; -.
DR   PRIDE; Q9UF47; -.
DR   ProteomicsDB; 84170; -.
DR   Antibodypedia; 24804; 90 antibodies from 17 providers.
DR   DNASU; 85479; -.
DR   Ensembl; ENST00000276570.10; ENSP00000276570.5; ENSG00000147570.10.
DR   GeneID; 85479; -.
DR   KEGG; hsa:85479; -.
DR   MANE-Select; ENST00000276570.10; ENSP00000276570.5; NM_033105.6; NP_149096.2.
DR   UCSC; uc003xvs.2; human.
DR   CTD; 85479; -.
DR   DisGeNET; 85479; -.
DR   GeneCards; DNAJC5B; -.
DR   HGNC; HGNC:24138; DNAJC5B.
DR   HPA; ENSG00000147570; Tissue enriched (testis).
DR   MIM; 613945; gene.
DR   neXtProt; NX_Q9UF47; -.
DR   OpenTargets; ENSG00000147570; -.
DR   PharmGKB; PA134962894; -.
DR   VEuPathDB; HostDB:ENSG00000147570; -.
DR   eggNOG; KOG0716; Eukaryota.
DR   GeneTree; ENSGT00940000159294; -.
DR   HOGENOM; CLU_017633_14_1_1; -.
DR   InParanoid; Q9UF47; -.
DR   OMA; MACNTPN; -.
DR   OrthoDB; 1401920at2759; -.
DR   PhylomeDB; Q9UF47; -.
DR   TreeFam; TF105164; -.
DR   PathwayCommons; Q9UF47; -.
DR   SignaLink; Q9UF47; -.
DR   BioGRID-ORCS; 85479; 11 hits in 1074 CRISPR screens.
DR   GenomeRNAi; 85479; -.
DR   Pharos; Q9UF47; Tdark.
DR   PRO; PR:Q9UF47; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q9UF47; protein.
DR   Bgee; ENSG00000147570; Expressed in sperm and 116 other tissues.
DR   ExpressionAtlas; Q9UF47; baseline and differential.
DR   Genevisible; Q9UF47; HS.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR036869; J_dom_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Lipoprotein; Membrane; Palmitate; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..199
FT                   /note="DnaJ homolog subfamily C member 5B"
FT                   /id="PRO_0000071055"
FT   DOMAIN          19..84
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   MOD_RES         14
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:D3ZD82"
FT   CONFLICT        41..44
FT                   /note="KLAL -> LENP (in Ref. 3; CAB63773)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   199 AA;  22496 MW;  4FDBF489D16B6EC0 CRC64;
     MACNIPNQRQ RTLSTTGEAL YEILGLHKGA SNEEIKKTYR KLALKHHPDK NPDDPAATEK
     FKEINNAHAI LTDISKRSIY DKYGSLGLYV AEQFGDENVN TYFMLSSWWA KALFVIVGLL
     TGCYFCCCLC CCCNCCCGHC RPESSVPEED FYVSPEDLEE QIKSDMEKDV DFPVFLQPTN
     ANEKTQLIKE GSRSYCTDS
 
 
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