DNJ5B_MOUSE
ID DNJ5B_MOUSE Reviewed; 199 AA.
AC Q9CQ94; Q810R9;
DT 03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=DnaJ homolog subfamily C member 5B;
DE AltName: Full=Cysteine-string protein isoform beta {ECO:0000303|PubMed:17034881};
DE Short=CSP-beta {ECO:0000303|PubMed:17034881};
GN Name=Dnajc5b; Synonyms=Cspbeta {ECO:0000303|PubMed:17034881};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH HSC70 AND SGTA.
RX PubMed=17034881; DOI=10.1016/j.bbamcr.2006.08.054;
RA Boal F., Le Pevelen S., Cziepluch C., Scotti P., Lang J.;
RT "Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-
RT Golgi network as a non-palmitoylated CSP in clonal beta-cells.";
RL Biochim. Biophys. Acta 1773:109-119(2007).
CC -!- SUBUNIT: Interacts with the chaperone complex consisting of HSC70 and
CC SGTA. {ECO:0000269|PubMed:17034881}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Lipid-anchor
CC {ECO:0000250}.
CC -!- PTM: Palmitoylated. {ECO:0000250}.
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DR EMBL; AK005749; BAB24221.1; -; mRNA.
DR EMBL; AK005725; BAB24206.1; -; mRNA.
DR EMBL; BC049579; AAH49579.1; -; mRNA.
DR CCDS; CCDS17257.1; -.
DR RefSeq; NP_001157008.1; NM_001163536.1.
DR RefSeq; NP_001157009.1; NM_001163537.1.
DR RefSeq; NP_079765.3; NM_025489.3.
DR RefSeq; XP_006535578.1; XM_006535515.1.
DR RefSeq; XP_006535579.1; XM_006535516.1.
DR AlphaFoldDB; Q9CQ94; -.
DR SMR; Q9CQ94; -.
DR CORUM; Q9CQ94; -.
DR STRING; 10090.ENSMUSP00000029132; -.
DR iPTMnet; Q9CQ94; -.
DR PhosphoSitePlus; Q9CQ94; -.
DR PaxDb; Q9CQ94; -.
DR PRIDE; Q9CQ94; -.
DR ProteomicsDB; 279560; -.
DR Antibodypedia; 24804; 90 antibodies from 17 providers.
DR DNASU; 66326; -.
DR Ensembl; ENSMUST00000029132; ENSMUSP00000029132; ENSMUSG00000027606.
DR Ensembl; ENSMUST00000118735; ENSMUSP00000113414; ENSMUSG00000027606.
DR Ensembl; ENSMUST00000118968; ENSMUSP00000112849; ENSMUSG00000027606.
DR Ensembl; ENSMUST00000165693; ENSMUSP00000127515; ENSMUSG00000027606.
DR GeneID; 66326; -.
DR KEGG; mmu:66326; -.
DR UCSC; uc008orv.2; mouse.
DR CTD; 85479; -.
DR MGI; MGI:1913576; Dnajc5b.
DR VEuPathDB; HostDB:ENSMUSG00000027606; -.
DR eggNOG; KOG0716; Eukaryota.
DR GeneTree; ENSGT00940000159294; -.
DR HOGENOM; CLU_017633_14_1_1; -.
DR InParanoid; Q9CQ94; -.
DR OMA; MACNTPN; -.
DR OrthoDB; 1401920at2759; -.
DR PhylomeDB; Q9CQ94; -.
DR TreeFam; TF105164; -.
DR BioGRID-ORCS; 66326; 0 hits in 75 CRISPR screens.
DR ChiTaRS; Dnajc5b; mouse.
DR PRO; PR:Q9CQ94; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9CQ94; protein.
DR Bgee; ENSMUSG00000027606; Expressed in seminiferous tubule of testis and 18 other tissues.
DR Genevisible; Q9CQ94; MM.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Chaperone; Lipoprotein; Membrane; Palmitate; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..199
FT /note="DnaJ homolog subfamily C member 5B"
FT /id="PRO_0000071056"
FT DOMAIN 19..84
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT MOD_RES 14
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:D3ZD82"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:D3ZD82"
FT CONFLICT 111
FT /note="K -> R (in Ref. 2; AAH49579)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 199 AA; 22662 MW; AEBFEBD396C823F3 CRC64;
MACNAPNQRQ RTLSTSGESL YEILGLHKGA SCEEIKKTYR KLALRHHPDK NPDDPSAAEK
FKEINNAHTI LTDTSKRNIY DKYGSLGLYV AEQFGDENVN TYFMLSSWWA KTLFIIIGLL
TGCYFCCCLC CCCNCCCGHC RPKSSTPEEE FYVSPEDLEE QIRTDMEKDM DFPVVLQPTN
TNEKTQLIRE GSRSYCTDS
