DNJ5G_HUMAN
ID DNJ5G_HUMAN Reviewed; 189 AA.
AC Q8N7S2; B4DY29; Q53SY5; Q8IYQ4; Q96RJ8;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=DnaJ homolog subfamily C member 5G;
DE AltName: Full=Cysteine string protein-gamma;
DE Short=CSP-gamma;
GN Name=DNAJC5G;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 57-165 (ISOFORM 1).
RA Tobaben S., Stahl B.;
RT "Novel isoforms of the cysteine string protein.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Lipid-anchor
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N7S2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N7S2-2; Sequence=VSP_056967, VSP_056968;
CC -!- TISSUE SPECIFICITY: Testis specific.
CC -!- PTM: Palmitoylated. {ECO:0000250}.
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DR EMBL; AK097736; BAC05155.1; -; mRNA.
DR EMBL; AK302239; BAG63591.1; -; mRNA.
DR EMBL; AC013413; AAY24295.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00608.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00609.1; -; Genomic_DNA.
DR EMBL; BC035194; AAH35194.2; -; mRNA.
DR EMBL; AF368277; AAK60572.1; -; mRNA.
DR CCDS; CCDS1744.1; -. [Q8N7S2-1]
DR CCDS; CCDS77397.1; -. [Q8N7S2-2]
DR RefSeq; NP_001290056.1; NM_001303127.1. [Q8N7S2-1]
DR RefSeq; NP_001290057.1; NM_001303128.1. [Q8N7S2-2]
DR RefSeq; NP_775921.1; NM_173650.2. [Q8N7S2-1]
DR RefSeq; XP_006712058.1; XM_006711995.3. [Q8N7S2-1]
DR RefSeq; XP_016859361.1; XM_017003872.1. [Q8N7S2-1]
DR RefSeq; XP_016859362.1; XM_017003873.1. [Q8N7S2-1]
DR RefSeq; XP_016859363.1; XM_017003874.1. [Q8N7S2-1]
DR AlphaFoldDB; Q8N7S2; -.
DR SMR; Q8N7S2; -.
DR BioGRID; 130021; 9.
DR STRING; 9606.ENSP00000296097; -.
DR iPTMnet; Q8N7S2; -.
DR PhosphoSitePlus; Q8N7S2; -.
DR BioMuta; DNAJC5G; -.
DR DMDM; 50400554; -.
DR MassIVE; Q8N7S2; -.
DR PaxDb; Q8N7S2; -.
DR PeptideAtlas; Q8N7S2; -.
DR PRIDE; Q8N7S2; -.
DR ProteomicsDB; 5491; -.
DR Antibodypedia; 28353; 126 antibodies from 24 providers.
DR DNASU; 285126; -.
DR Ensembl; ENST00000296097.8; ENSP00000296097.3; ENSG00000163793.13. [Q8N7S2-1]
DR Ensembl; ENST00000402462.5; ENSP00000384305.1; ENSG00000163793.13. [Q8N7S2-1]
DR Ensembl; ENST00000406962.1; ENSP00000385533.1; ENSG00000163793.13. [Q8N7S2-2]
DR GeneID; 285126; -.
DR KEGG; hsa:285126; -.
DR MANE-Select; ENST00000296097.8; ENSP00000296097.3; NM_173650.3; NP_775921.1.
DR UCSC; uc002rjl.2; human. [Q8N7S2-1]
DR CTD; 285126; -.
DR GeneCards; DNAJC5G; -.
DR HGNC; HGNC:24844; DNAJC5G.
DR HPA; ENSG00000163793; Group enriched (epididymis, testis).
DR MIM; 613946; gene.
DR neXtProt; NX_Q8N7S2; -.
DR OpenTargets; ENSG00000163793; -.
DR PharmGKB; PA134880296; -.
DR VEuPathDB; HostDB:ENSG00000163793; -.
DR eggNOG; KOG0716; Eukaryota.
DR GeneTree; ENSGT00940000162434; -.
DR HOGENOM; CLU_2249162_0_0_1; -.
DR InParanoid; Q8N7S2; -.
DR OMA; RYQQNVQ; -.
DR OrthoDB; 1401920at2759; -.
DR PhylomeDB; Q8N7S2; -.
DR TreeFam; TF105164; -.
DR PathwayCommons; Q8N7S2; -.
DR BioGRID-ORCS; 285126; 15 hits in 1069 CRISPR screens.
DR GenomeRNAi; 285126; -.
DR Pharos; Q8N7S2; Tdark.
DR PRO; PR:Q8N7S2; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8N7S2; protein.
DR Bgee; ENSG00000163793; Expressed in left testis and 76 other tissues.
DR ExpressionAtlas; Q8N7S2; baseline and differential.
DR Genevisible; Q8N7S2; HS.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR036869; J_dom_sf.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 2.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chaperone; Lipoprotein; Membrane; Palmitate;
KW Reference proteome.
FT CHAIN 1..189
FT /note="DnaJ homolog subfamily C member 5G"
FT /id="PRO_0000071057"
FT DOMAIN 17..98
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 154..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 38..104
FT /note="SHSALLPHPPFEYHLGRKLALRYHPDKNPGNAQAAEIFKEINAAHAILSDSK
FT KRKIYDQHGSLGIYL -> RHLSSCVLCSLVAVSVVAAVFAVEHLNHHLSRIVGENISR
FT MSRVSLQGQEPNVILEARKIAKMIFKR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056967"
FT VAR_SEQ 105..189
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056968"
FT VARIANT 4
FT /note="V -> G (in dbSNP:rs17005979)"
FT /id="VAR_033882"
FT VARIANT 51
FT /note="H -> R (in dbSNP:rs13414011)"
FT /id="VAR_033883"
SQ SEQUENCE 189 AA; 21433 MW; EF8FCAE0F1A841A1 CRC64;
MSTVKEAAHR LSKSEMSLYA VLDLKKGASP EDFKKSYSHS ALLPHPPFEY HLGRKLALRY
HPDKNPGNAQ AAEIFKEINA AHAILSDSKK RKIYDQHGSL GIYLYDHFGE EGVRYYFILN
SCWFKTLVIL CTLLTCCCFC CCCCFCCGAL KPPPEQDSGR KYQQNVQSQP PRSGAKCDFR
SEENSEDDF
