DNJ60_DROME
ID DNJ60_DROME Reviewed; 217 AA.
AC P92029;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=DnaJ-like protein 60;
GN Name=DnaJ-60; Synonyms=DmJ60, DnaJ60; ORFNames=CG12240;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oregon-R; TISSUE=Embryo;
RX PubMed=9372188;
RA Iliopoulos I., Toeroek I., Mechler B.M.;
RT "The DnaJ60 gene of Drosophila melanogaster encodes a new member of the
RT DnaJ family of proteins.";
RL Biol. Chem. 378:1177-1181(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: May play an important function during spermatogenesis and/or
CC in the male genital tract.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis and ejaculatory bulb.
CC -!- DEVELOPMENTAL STAGE: Weakly expressed in embryos, larvae and adult
CC females. Strong expression in adult males.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Y11900; CAA72641.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF47174.1; -; Genomic_DNA.
DR RefSeq; NP_523840.1; NM_079116.4.
DR RefSeq; NP_611892.2; NM_138048.3.
DR AlphaFoldDB; P92029; -.
DR SMR; P92029; -.
DR STRING; 7227.FBpp0290487; -.
DR PaxDb; P92029; -.
DR EnsemblMetazoa; FBtr0301271; FBpp0290486; FBgn0260775.
DR EnsemblMetazoa; FBtr0301272; FBpp0290487; FBgn0260775.
DR GeneID; 37869; -.
DR KEGG; dme:Dmel_CG42567; -.
DR UCSC; CG12240-RA; d. melanogaster.
DR CTD; 37869; -.
DR FlyBase; FBgn0260775; DnaJ-60.
DR VEuPathDB; VectorBase:FBgn0260775; -.
DR eggNOG; KOG0715; Eukaryota.
DR HOGENOM; CLU_088052_0_0_1; -.
DR InParanoid; P92029; -.
DR OMA; AGYVRNF; -.
DR PhylomeDB; P92029; -.
DR BioGRID-ORCS; 37869; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37869; -.
DR PRO; PR:P92029; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0260775; Expressed in testis and 12 other tissues.
DR Genevisible; P92029; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISM:FlyBase.
DR GO; GO:0051082; F:unfolded protein binding; ISS:FlyBase.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0042026; P:protein refolding; ISS:FlyBase.
DR GO; GO:0009408; P:response to heat; ISS:FlyBase.
DR GO; GO:0007283; P:spermatogenesis; IEP:FlyBase.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Developmental protein; Differentiation; Membrane;
KW Reference proteome; Spermatogenesis; Transmembrane; Transmembrane helix.
FT CHAIN 1..217
FT /note="DnaJ-like protein 60"
FT /id="PRO_0000071007"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 26..93
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 95..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 217 AA; 24780 MW; 5E2FF61832FFD0CC CRC64;
MLRLCLPTRA GYVRNFSNDK PRKPETHYEV LNIRNDCSTR EVRNAFVQLS KLYHPDVKSN
AACPERTARF VQISEAYKTL IKPERRRDYD DSLLWQPSRS DRSPVGETVN PGQAWDVRPN
YDPNPGPYYG IRGLKRVSNW QVAVVLMALG FVGALFGFTS VRSSFKLSRQ IQDEISAEAN
SHHAAVVADA QKYGNEEQVR RMVDRMSRSP FNQSSAK
