ID   DNJ6A_XENLA             Reviewed;         250 AA.
AC   Q5FWN8;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DnaJ homolog subfamily B member 6-A;
GN   Name=dnajb6-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH89266.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg {ECO:0000312|EMBL:AAH89266.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an indispensable role in the organization of krt8/krt18
CC       filaments. Acts as an endogenous molecular chaperone for neuronal
CC       proteins including huntingtin. Has a stimulatory effect on the ATPase
CC       activity of HSP70 in a dose-dependent and time-dependent manner and
CC       hence acts as a co-chaperone of HSP70 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:O75190}. Nucleus {ECO:0000250|UniProtKB:O75190}.
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DR   EMBL; BC089266; AAH89266.1; -; mRNA.
DR   RefSeq; NP_001089244.1; NM_001095775.1.
DR   AlphaFoldDB; Q5FWN8; -.
DR   SMR; Q5FWN8; -.
DR   BioGRID; 592072; 1.
DR   IntAct; Q5FWN8; 1.
DR   PRIDE; Q5FWN8; -.
DR   DNASU; 734291; -.
DR   GeneID; 734291; -.
DR   CTD; 734291; -.
DR   Xenbase; XB-GENE-954099; dnajb6.L.
DR   OrthoDB; 1152652at2759; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 734291; Expressed in heart and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR036869; J_dom_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..250
FT                   /note="DnaJ homolog subfamily B member 6-A"
FT                   /id="PRO_0000292342"
FT   DOMAIN          3..69
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ   SEQUENCE   250 AA;  27782 MW;  D9BDEBAA2F127944 CRC64;
     MVEYYEVLGV QRNASADDIK KAYRRLALKW HPDKNPDNKD EAERRFKEVA EAYEVLSDSK
     KRDIYDKYGK EGLTNRGGGS HFDEAPFQFG FTFRSPDDVF RDFFGGRDPF SFDLFADDPF
     DDFFGRSRHR ANRSRPAGGG GGPFLSTFGG FPAFGPSFSP FDSGFSSSFG SFGGHGGHGG
     FTSFSSSSFG GSEMGNFRSV STSTKVVNGR RVTTKRIVEN GQERVEVEED GQLKSLTVNG
     KEQLLRLDNK