DNJ6B_XENLA
ID DNJ6B_XENLA Reviewed; 245 AA.
AC Q5XGU5;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=DnaJ homolog subfamily B member 6-B;
GN Name=dnajb6-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000312|EMBL:AAH84334.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000312|EMBL:AAH84334.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an indispensable role in the organization of krt8/krt18
CC filaments. Acts as an endogenous molecular chaperone for neuronal
CC proteins including huntingtin. Has a stimulatory effect on the ATPase
CC activity of HSP70 in a dose-dependent and time-dependent manner and
CC hence acts as a co-chaperone of HSP70 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:O75190}. Nucleus {ECO:0000250|UniProtKB:O75190}.
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DR EMBL; BC084334; AAH84334.1; -; mRNA.
DR RefSeq; NP_001088302.1; NM_001094833.1.
DR AlphaFoldDB; Q5XGU5; -.
DR SMR; Q5XGU5; -.
DR DNASU; 495138; -.
DR GeneID; 495138; -.
DR CTD; 495138; -.
DR Xenbase; XB-GENE-972418; dnajb6.S.
DR OrthoDB; 1152652at2759; -.
DR Proteomes; UP000186698; Genome assembly.
DR Bgee; 495138; Expressed in heart and 19 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR036869; J_dom_sf.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..245
FT /note="DnaJ homolog subfamily B member 6-B"
FT /id="PRO_0000292343"
FT DOMAIN 3..69
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ SEQUENCE 245 AA; 27113 MW; 0410198361482984 CRC64;
MVEYYDVLGV QRNSSPDDIK KAYRRLALKW HPDKNPDNKE EAERRFKEVA EAYEVLSDSK
KRDIYDKYGK EGLAGGGGGG GSHYDVPFQF GFTFRSPDDV FREFFGGRDP FSFDLFAEDP
FDDFFGRRGH RGNRSRPGGG SFLSTFGGFP AFGPSFSPFD SGFSSSFGSF GGHGGFTSFS
SSSFGGSGMG NVRSVSTSTK IVNGRRVTTK RIVENGQERV EVEEDGQLKS LTINGKEQLL
RLDNK