位置:首页 > 蛋白库 > DNJ6B_XENLA
DNJ6B_XENLA
ID   DNJ6B_XENLA             Reviewed;         245 AA.
AC   Q5XGU5;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DnaJ homolog subfamily B member 6-B;
GN   Name=dnajb6-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH84334.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:AAH84334.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an indispensable role in the organization of krt8/krt18
CC       filaments. Acts as an endogenous molecular chaperone for neuronal
CC       proteins including huntingtin. Has a stimulatory effect on the ATPase
CC       activity of HSP70 in a dose-dependent and time-dependent manner and
CC       hence acts as a co-chaperone of HSP70 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:O75190}. Nucleus {ECO:0000250|UniProtKB:O75190}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC084334; AAH84334.1; -; mRNA.
DR   RefSeq; NP_001088302.1; NM_001094833.1.
DR   AlphaFoldDB; Q5XGU5; -.
DR   SMR; Q5XGU5; -.
DR   DNASU; 495138; -.
DR   GeneID; 495138; -.
DR   CTD; 495138; -.
DR   Xenbase; XB-GENE-972418; dnajb6.S.
DR   OrthoDB; 1152652at2759; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 495138; Expressed in heart and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR036869; J_dom_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..245
FT                   /note="DnaJ homolog subfamily B member 6-B"
FT                   /id="PRO_0000292343"
FT   DOMAIN          3..69
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ   SEQUENCE   245 AA;  27113 MW;  0410198361482984 CRC64;
     MVEYYDVLGV QRNSSPDDIK KAYRRLALKW HPDKNPDNKE EAERRFKEVA EAYEVLSDSK
     KRDIYDKYGK EGLAGGGGGG GSHYDVPFQF GFTFRSPDDV FREFFGGRDP FSFDLFAEDP
     FDDFFGRRGH RGNRSRPGGG SFLSTFGGFP AFGPSFSPFD SGFSSSFGSF GGHGGFTSFS
     SSSFGGSGMG NVRSVSTSTK IVNGRRVTTK RIVENGQERV EVEEDGQLKS LTINGKEQLL
     RLDNK
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024