ID   DNJB4_BOVIN             Reviewed;         337 AA.
AC   Q2KIT4;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DnaJ homolog subfamily B member 4;
GN   Name=DNAJB4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable chaperone. Stimulates ATP hydrolysis and the folding
CC       of unfolded proteins mediated by HSPA1A/B (in vitro).
CC       {ECO:0000250|UniProtKB:Q9UDY4}.
CC   -!- SUBUNIT: Homodimer. The C-terminal section interacts with the C-
CC       terminal tail of OPRM1. Interacts also with SDIM1.
CC       {ECO:0000250|UniProtKB:Q9UDY4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UDY4}. Cell
CC       membrane {ECO:0000250|UniProtKB:Q9UDY4}.
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DR   EMBL; BC112518; AAI12519.1; -; mRNA.
DR   RefSeq; NP_001039968.1; NM_001046503.1.
DR   AlphaFoldDB; Q2KIT4; -.
DR   SMR; Q2KIT4; -.
DR   STRING; 9913.ENSBTAP00000028994; -.
DR   PaxDb; Q2KIT4; -.
DR   PRIDE; Q2KIT4; -.
DR   Ensembl; ENSBTAT00000028994; ENSBTAP00000028994; ENSBTAG00000021752.
DR   GeneID; 541274; -.
DR   KEGG; bta:541274; -.
DR   CTD; 11080; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021752; -.
DR   VGNC; VGNC:55166; DNAJB4.
DR   eggNOG; KOG0714; Eukaryota.
DR   GeneTree; ENSGT00940000156826; -.
DR   HOGENOM; CLU_017633_0_0_1; -.
DR   InParanoid; Q2KIT4; -.
DR   OMA; DVNFPET; -.
DR   OrthoDB; 1393097at2759; -.
DR   TreeFam; TF105141; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000021752; Expressed in gluteal muscle and 105 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001671; F:ATPase activator activity; ISS:UniProtKB.
DR   GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR002939; DnaJ_C.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR   InterPro; IPR036869; J_dom_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF01556; DnaJ_C; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   SUPFAM; SSF49493; SSF49493; 2.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Chaperone; Cytoplasm; Membrane; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..337
FT                   /note="DnaJ homolog subfamily B member 4"
FT                   /id="PRO_0000286174"
FT   DOMAIN          2..70
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   MOD_RES         122
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UDY4"
FT   MOD_RES         148
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UDY4"
SQ   SEQUENCE   337 AA;  37851 MW;  B782AEA625092421 CRC64;
     MGKDYYCILG IEKGASDEDI KKAYRKQALR FHPDKNKSPQ AEERFKEVAE AYEVLSDPKK
     REIYDQFGEE GLKGGAGGTD GQGGTFRYTF HGDPHATFAA FFGGSNPFEI FFGRRMGGGR
     DSDEMEVDGD PFGAFGFSMN GYPRDRNSVG PSRLKQDPPV IHELRVSLEE IYSGCTKRMK
     ISRKRLNPDG RSYRTEDKIL TIEIKKGWKE GTKITFPREG DETPTSIPAD IVFVIKDKDH
     PKFKRDGSNI IYTAKISLRE ALCGCSINVP TMDGRTIPMT INDIVKPGMR RRIIGYGLPF
     PKNPDQRGDL LIEFEVSFPD TISSSSKEVL RKHLPAS