ID   DNJB5_MOUSE             Reviewed;         348 AA.
AC   O89114;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=DnaJ homolog subfamily B member 5;
DE   AltName: Full=Heat shock protein Hsp40-3;
DE   AltName: Full=Heat shock protein cognate 40;
DE            Short=Hsc40;
GN   Name=Dnajb5; Synonyms=Hsc40;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10570961; DOI=10.1016/s0378-1119(99)00333-9;
RA   Chen M.-S., Roti J.R., Laszlo A.;
RT   "Hsc40, a new member of the hsp40 family, exhibits similar expression
RT   profile to that of hsc70 in mammalian cells.";
RL   Gene 238:333-341(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain, and Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INDUCTION: Expressed under normal conditions, its expression can
CC       further be increased after various stress treatments.
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DR   EMBL; AF092536; AAC64141.1; -; Genomic_DNA.
DR   EMBL; AF088983; AAC35861.1; -; mRNA.
DR   EMBL; AF321322; AAG53972.1; -; mRNA.
DR   EMBL; BC048902; AAH48902.1; -; mRNA.
DR   EMBL; BC057087; AAH57087.1; -; mRNA.
DR   CCDS; CCDS18084.1; -.
DR   RefSeq; NP_063927.1; NM_019874.3.
DR   RefSeq; XP_006538174.1; XM_006538111.3.
DR   RefSeq; XP_006538175.1; XM_006538112.3.
DR   AlphaFoldDB; O89114; -.
DR   SMR; O89114; -.
DR   BioGRID; 207903; 2.
DR   IntAct; O89114; 1.
DR   MINT; O89114; -.
DR   STRING; 10090.ENSMUSP00000081712; -.
DR   iPTMnet; O89114; -.
DR   PhosphoSitePlus; O89114; -.
DR   EPD; O89114; -.
DR   PaxDb; O89114; -.
DR   PRIDE; O89114; -.
DR   ProteomicsDB; 279456; -.
DR   Antibodypedia; 11397; 191 antibodies from 28 providers.
DR   DNASU; 56323; -.
DR   Ensembl; ENSMUST00000084662; ENSMUSP00000081712; ENSMUSG00000036052.
DR   Ensembl; ENSMUST00000098112; ENSMUSP00000095716; ENSMUSG00000036052.
DR   Ensembl; ENSMUST00000107973; ENSMUSP00000103607; ENSMUSG00000036052.
DR   GeneID; 56323; -.
DR   UCSC; uc008som.1; mouse.
DR   CTD; 25822; -.
DR   MGI; MGI:1930018; Dnajb5.
DR   VEuPathDB; HostDB:ENSMUSG00000036052; -.
DR   eggNOG; KOG0714; Eukaryota.
DR   GeneTree; ENSGT00940000156090; -.
DR   HOGENOM; CLU_017633_0_0_1; -.
DR   InParanoid; O89114; -.
DR   OrthoDB; 1393097at2759; -.
DR   TreeFam; TF105141; -.
DR   BioGRID-ORCS; 56323; 0 hits in 73 CRISPR screens.
DR   ChiTaRS; Dnajb5; mouse.
DR   PRO; PR:O89114; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; O89114; protein.
DR   Bgee; ENSMUSG00000036052; Expressed in embryonic brain and 261 other tissues.
DR   ExpressionAtlas; O89114; baseline and differential.
DR   Genevisible; O89114; MM.
DR   GO; GO:0005829; C:cytosol; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0051087; F:chaperone binding; ISO:MGI.
DR   GO; GO:0051082; F:unfolded protein binding; ISS:MGI.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:MGI.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR002939; DnaJ_C.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR   InterPro; IPR036869; J_dom_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF01556; DnaJ_C; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   SUPFAM; SSF49493; SSF49493; 2.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Reference proteome.
FT   CHAIN           1..348
FT                   /note="DnaJ homolog subfamily B member 5"
FT                   /id="PRO_0000071024"
FT   DOMAIN          4..68
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ   SEQUENCE   348 AA;  39119 MW;  833D2F3547321687 CRC64;
     MGKDYYKILG IPSGANEDEI KKAYRKMALK YHPDKNKEPN AEEKFKEIAE AYDVLSDPKK
     RSLYDQYGEE GLKTGGGSSG GSGGSFHYTF HGDPHATFAS FFGGSNPFDI FFASSRSTRP
     FSGFDPDDMD VDEDEDPFGA FGRFGFNGLS RGPRRAPEPL YPRRKVQDPP VVHELRVSLE
     EIYHGSTKRM KITRRRLNPD GRTVRTEDKI LHIVIKRGWK EGTKITFPKE GDATPDNIPA
     DIVFVLKDKP HAHFRRDGTN VLYSALISLK EALCGCTVNI PTIDGRVIPL PCNDVIKPGT
     VKRLRGEGLP FPKVPTQRGD LIVEFKVRFP DRLTPQTRQI LKQHLPCS