ID   DNJB7_HUMAN             Reviewed;         309 AA.
AC   Q7Z6W7; Q2M220; Q5H904; Q8WYJ7;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=DnaJ homolog subfamily B member 7;
GN   Name=DNAJB7; Synonyms=HSC3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Xing Y., Yu L., Fu Q., Zhao Y., Bi A., Zhao S.;
RT   "Cloning a novel human gene, HSC3, which shows significant homology to
RT   murine MRJ.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA   Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA   Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA   Beare D.M., Dunham I.;
RT   "A genome annotation-driven approach to cloning the human ORFeome.";
RL   Genome Biol. 5:R84.1-R84.11(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably acts as a co-chaperone. {ECO:0000250}.
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DR   EMBL; AF085232; AAL40391.1; -; mRNA.
DR   EMBL; CR456468; CAG30354.1; -; mRNA.
DR   EMBL; Z98048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC112135; AAI12136.1; -; mRNA.
DR   CCDS; CCDS14008.1; -.
DR   RefSeq; NP_660157.1; NM_145174.1.
DR   AlphaFoldDB; Q7Z6W7; -.
DR   SMR; Q7Z6W7; -.
DR   BioGRID; 127284; 33.
DR   IntAct; Q7Z6W7; 1.
DR   STRING; 9606.ENSP00000307197; -.
DR   iPTMnet; Q7Z6W7; -.
DR   PhosphoSitePlus; Q7Z6W7; -.
DR   BioMuta; DNAJB7; -.
DR   DMDM; 44887848; -.
DR   jPOST; Q7Z6W7; -.
DR   MassIVE; Q7Z6W7; -.
DR   MaxQB; Q7Z6W7; -.
DR   PaxDb; Q7Z6W7; -.
DR   PeptideAtlas; Q7Z6W7; -.
DR   PRIDE; Q7Z6W7; -.
DR   ProteomicsDB; 69469; -.
DR   Antibodypedia; 256; 41 antibodies from 17 providers.
DR   DNASU; 150353; -.
DR   Ensembl; ENST00000307221.5; ENSP00000307197.4; ENSG00000172404.5.
DR   GeneID; 150353; -.
DR   KEGG; hsa:150353; -.
DR   MANE-Select; ENST00000307221.5; ENSP00000307197.4; NM_145174.2; NP_660157.1.
DR   UCSC; uc003azj.4; human.
DR   CTD; 150353; -.
DR   DisGeNET; 150353; -.
DR   GeneCards; DNAJB7; -.
DR   HGNC; HGNC:24986; DNAJB7.
DR   HPA; ENSG00000172404; Tissue enriched (testis).
DR   MIM; 611336; gene.
DR   neXtProt; NX_Q7Z6W7; -.
DR   OpenTargets; ENSG00000172404; -.
DR   PharmGKB; PA134961522; -.
DR   VEuPathDB; HostDB:ENSG00000172404; -.
DR   eggNOG; KOG0714; Eukaryota.
DR   GeneTree; ENSGT00940000163470; -.
DR   HOGENOM; CLU_017633_12_0_1; -.
DR   InParanoid; Q7Z6W7; -.
DR   OMA; QYTFVDN; -.
DR   OrthoDB; 1472647at2759; -.
DR   PhylomeDB; Q7Z6W7; -.
DR   TreeFam; TF105142; -.
DR   PathwayCommons; Q7Z6W7; -.
DR   SignaLink; Q7Z6W7; -.
DR   BioGRID-ORCS; 150353; 9 hits in 1064 CRISPR screens.
DR   GenomeRNAi; 150353; -.
DR   Pharos; Q7Z6W7; Tbio.
DR   PRO; PR:Q7Z6W7; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; Q7Z6W7; protein.
DR   Bgee; ENSG00000172404; Expressed in right testis and 80 other tissues.
DR   Genevisible; Q7Z6W7; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0051087; F:chaperone binding; IPI:UniProtKB.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0061077; P:chaperone-mediated protein folding; IBA:GO_Central.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR036869; J_dom_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Reference proteome.
FT   CHAIN           1..309
FT                   /note="DnaJ homolog subfamily B member 7"
FT                   /id="PRO_0000071027"
FT   DOMAIN          3..69
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   REGION          282..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..309
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         41
FT                   /note="E -> A (in dbSNP:rs2269619)"
FT                   /id="VAR_017779"
SQ   SEQUENCE   309 AA;  35434 MW;  64F0F8544CDB8984 CRC64;
     MVDYYEVLGL QRYASPEDIK KAYHKVALKW HPDKNPENKE EAERKFKEVA EAYEVLSNDE
     KRDIYDKYGT EGLNGGGSHF DDECEYGFTF HKPDDVFKEI FHERDPFSFH FFEDSLEDLL
     NRPGSSYGNR NRDAGYFFST ASEYPIFEKF SSYDTGYTSQ GSLGHEGLTS FSSLAFDNSG
     MDNYISVTTS DKIVNGRNIN TKKIIESDQE REAEDNGELT FFLVNSVANE EGFAKECSWR
     TQSFNNYSPN SHSSKHVSQY TFVDNDEGGI SWVTSNRDPP IFSAGVKEGG KRKKKKRKEV
     QKKSTKRNC