DNJC2_DANRE
ID DNJC2_DANRE Reviewed; 618 AA.
AC Q6NWJ4; Q7SY51;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=DnaJ homolog subfamily C member 2;
GN Name=dnajc2; ORFNames=zgc:85671;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB; TISSUE=Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts both as a chaperone in the cytosol and as a chromatin
CC regulator in the nucleus. When cytosolic, acts as a molecular
CC chaperone: component of the ribosome-associated complex (RAC), a
CC complex involved in folding or maintaining nascent polypeptides in a
CC folding-competent state. When nuclear, mediates the switching from
CC polycomb-repressed genes to an active state: specifically recruited at
CC histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the
CC displacement of the polycomb PRC1 complex from chromatin, thereby
CC facilitating transcription activation (By similarity).
CC {ECO:0000250|UniProtKB:Q99543}.
CC -!- SUBUNIT: Component of ribosome-associated complex (RAC).
CC {ECO:0000250|UniProtKB:Q99543}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
CC Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q99543}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH55125.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; BC055125; AAH55125.1; ALT_SEQ; mRNA.
DR EMBL; BC067568; AAH67568.1; -; mRNA.
DR RefSeq; NP_997976.1; NM_212811.1.
DR AlphaFoldDB; Q6NWJ4; -.
DR SMR; Q6NWJ4; -.
DR STRING; 7955.ENSDARP00000094239; -.
DR PaxDb; Q6NWJ4; -.
DR PRIDE; Q6NWJ4; -.
DR Ensembl; ENSDART00000103463; ENSDARP00000094239; ENSDARG00000070477.
DR GeneID; 403080; -.
DR KEGG; dre:403080; -.
DR CTD; 27000; -.
DR ZFIN; ZDB-GENE-040426-1912; dnajc2.
DR eggNOG; KOG0724; Eukaryota.
DR GeneTree; ENSGT00940000155441; -.
DR HOGENOM; CLU_019916_0_0_1; -.
DR InParanoid; Q6NWJ4; -.
DR OMA; QNGVDHK; -.
DR OrthoDB; 1392575at2759; -.
DR PhylomeDB; Q6NWJ4; -.
DR TreeFam; TF105834; -.
DR Reactome; R-DRE-3371453; Regulation of HSF1-mediated heat shock response.
DR PRO; PR:Q6NWJ4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000070477; Expressed in mature ovarian follicle and 27 other tissues.
DR ExpressionAtlas; Q6NWJ4; baseline.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0042393; F:histone binding; ISS:UniProtKB.
DR GO; GO:0030544; F:Hsp70 protein binding; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0061649; F:ubiquitin modification-dependent histone binding; ISS:UniProtKB.
DR GO; GO:0051083; P:'de novo' cotranslational protein folding; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006450; P:regulation of translational fidelity; IEA:InterPro.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd00167; SANT; 2.
DR Gene3D; 1.10.287.110; -; 1.
DR Gene3D; 1.10.8.840; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR032003; RAC_head.
DR InterPro; IPR042569; RAC_head_sf.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR044634; Zuotin/DnaJC2.
DR PANTHER; PTHR43999; PTHR43999; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR Pfam; PF16717; RAC_head; 1.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51293; SANT; 2.
PE 2: Evidence at transcript level;
KW Activator; Chaperone; Chromatin regulator; Cytoplasm; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..618
FT /note="DnaJ homolog subfamily C member 2"
FT /id="PRO_0000405822"
FT DOMAIN 85..158
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT DOMAIN 445..507
FT /note="SANT 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT DOMAIN 548..603
FT /note="SANT 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT REGION 281..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 71598 MW; A3CED6642F15FED1 CRC64;
MLTEALEGQL TVVYNTVAAS VQVQVEPVGR WFEAFLKRRN RNVSASFQEL EEEEELSEEE
EDEELQLEEY PMLKTLDPKD WKNQDHYAVL GLAHVRYKAT QKQIKAAHKA MVLKHHPDKR
KAAGEQIVEG DNDYFTCITK AIEILSDPVK RRAFDSVDPT FDNAVPTKAE GKENFFEVFA
PVFERNARWS VKKHFPSLGT MESSFEDVDN FYSFWYNFDS WREFSYLDEE EKEKAECRDE
RRWIEKQNRA SRAQRKKEEM NRIRTLVDTA YNADPRIKKF KEEEKARKES EKKAKVEAKK
REQEEKERAR QQQEEAARLL KEQQEEAARQ AAQQAKKEKE AQKKAIKKER QKLRMTCKSQ
NYFTDNEADS VRMMEEVEKL CDRLELISLQ TLNEALSAGN KEQSKAALEK QVQEVNMQLQ
KEKDAELQAQ QAARGSEHSS AAGGQNNRGW SEEDLQLLIK AVNLFPAGTN ARWEVIANYM
NQHSSSGVRR TAKDVINKAK TLQKLDPHQK DEINRKAFEK FKKEHSAVPP TVDNAMPSER
FDAVGADSNA AAWTTEEQKL LEQALKTYPV STAERWERIS EAVPGRSKKD CMKRYKELVE
MIKAKKAAQE QVAAKNKK
