ID   DNJC3_CHICK             Reviewed;         503 AA.
AC   Q5ZI13;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=DnaJ homolog subfamily C member 3;
DE   Flags: Precursor;
GN   Name=DNAJC3; ORFNames=RCJMB04_31h14;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May be involved in the unfolded protein response (UPR) during
CC       ER stress. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
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DR   EMBL; AJ720971; CAG32630.1; -; mRNA.
DR   RefSeq; NP_001008437.1; NM_001008437.1.
DR   AlphaFoldDB; Q5ZI13; -.
DR   SMR; Q5ZI13; -.
DR   STRING; 9031.ENSGALP00000027249; -.
DR   PaxDb; Q5ZI13; -.
DR   GeneID; 418787; -.
DR   KEGG; gga:418787; -.
DR   CTD; 5611; -.
DR   VEuPathDB; HostDB:geneid_418787; -.
DR   eggNOG; KOG0624; Eukaryota.
DR   HOGENOM; CLU_015935_0_0_1; -.
DR   InParanoid; Q5ZI13; -.
DR   PhylomeDB; Q5ZI13; -.
DR   PRO; PR:Q5ZI13; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR   GO; GO:0004860; F:protein kinase inhibitor activity; ISS:UniProtKB.
DR   GO; GO:0070417; P:cellular response to cold; ISS:UniProtKB.
DR   GO; GO:1903912; P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; ISS:UniProtKB.
DR   GO; GO:0036494; P:positive regulation of translation initiation in response to endoplasmic reticulum stress; ISS:UniProtKB.
DR   GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SMART; SM00028; TPR; 9.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50076; DNAJ_2; 1.
DR   PROSITE; PS50005; TPR; 8.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Disulfide bond; Endoplasmic reticulum; Reference proteome;
KW   Repeat; Signal; TPR repeat; Unfolded protein response.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..503
FT                   /note="DnaJ homolog subfamily C member 3"
FT                   /id="PRO_0000071048"
FT   REPEAT          37..70
FT                   /note="TPR 1"
FT   REPEAT          71..104
FT                   /note="TPR 2"
FT   REPEAT          105..137
FT                   /note="TPR 3"
FT   REPEAT          153..186
FT                   /note="TPR 4"
FT   REPEAT          187..220
FT                   /note="TPR 5"
FT   REPEAT          221..254
FT                   /note="TPR 6"
FT   REPEAT          267..300
FT                   /note="TPR 7"
FT   REPEAT          305..338
FT                   /note="TPR 8"
FT   REPEAT          339..372
FT                   /note="TPR 9"
FT   DOMAIN          393..461
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   REGION          374..392
FT                   /note="Flexible linker"
FT                   /evidence="ECO:0000250"
FT   DISULFID        247..257
FT                   /evidence="ECO:0000250"
FT   DISULFID        312..328
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   503 AA;  57327 MW;  22CE3024A8BA8E68 CRC64;
     MVSAAASAGR LGSALPFLLV LLDLQYQGAE CGINAEVEKQ LEMGKKLLAA GQLADALSHF
     HAAIEGDSDN YIAYYRRATV YLAMGKSKAA IRDLSKVVEL KQDFTSRLQR GHLLLKQGKF
     DEAEDDFKNV LKSNPSNNEE KEAQTQLTKS DELQRLYSQA LSAYRQEDYE AAIPLLDEIL
     AVCVWDAELR ELRAECYIKE GEPSKAISDL KAAAKLKSDN TEAFYKISRI YYQLGDHELS
     LSEVRECLKL DQDHKQCFSL YKQVKKLNKQ IESAEEFIRE GRYEDAISKY DSVMKTEPDV
     PVYATRAKER ICHCLSKNQQ ATEAITVCTQ VLQLEPTNVN ALKDRAEAYL LEDLYEEAIK
     DYETAQANSE NDQQIREGLE RAQRMLKQSQ KRDYYKILGV KRNARKQEII KAYRKLASQW
     HPDNFQSEEE KKKAEKKFID IAAAKEVLTD PEMRRKFDAG EDPLDAESQQ GGGNPFHRNW
     NTWQGFNPFG SGGGPFTFKF HFS