DNJC3_DICDI
ID DNJC3_DICDI Reviewed; 502 AA.
AC Q54M21;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=DnaJ homolog subfamily C member 3 homolog;
DE Flags: Precursor;
GN Name=dnajc3; ORFNames=DDB_G0286251;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May be involved in the unfolded protein response (UPR) during
CC ER stress. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Endoplasmic reticulum
CC lumen {ECO:0000250}.
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DR EMBL; AAFI02000085; EAL64301.1; -; Genomic_DNA.
DR RefSeq; XP_637810.1; XM_632718.1.
DR AlphaFoldDB; Q54M21; -.
DR SMR; Q54M21; -.
DR STRING; 44689.DDB0233602; -.
DR PaxDb; Q54M21; -.
DR EnsemblProtists; EAL64301; EAL64301; DDB_G0286251.
DR GeneID; 8625524; -.
DR KEGG; ddi:DDB_G0286251; -.
DR dictyBase; DDB_G0286251; dnajc3.
DR eggNOG; KOG0624; Eukaryota.
DR HOGENOM; CLU_015935_0_0_1; -.
DR InParanoid; Q54M21; -.
DR OMA; PFAHFQH; -.
DR PhylomeDB; Q54M21; -.
DR PRO; PR:Q54M21; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF46565; SSF46565; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50005; TPR; 8.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Chaperone; Disulfide bond; Endoplasmic reticulum; Glycoprotein;
KW Reference proteome; Repeat; Secreted; Signal; TPR repeat;
KW Unfolded protein response.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..502
FT /note="DnaJ homolog subfamily C member 3 homolog"
FT /id="PRO_0000328415"
FT REPEAT 29..62
FT /note="TPR 1"
FT REPEAT 69..102
FT /note="TPR 2"
FT REPEAT 103..136
FT /note="TPR 3"
FT REPEAT 184..217
FT /note="TPR 4"
FT REPEAT 218..251
FT /note="TPR 5"
FT REPEAT 264..297
FT /note="TPR 6"
FT REPEAT 302..335
FT /note="TPR 7"
FT REPEAT 336..369
FT /note="TPR 8"
FT DOMAIN 390..457
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 309..325
FT /evidence="ECO:0000250"
SQ SEQUENCE 502 AA; 57387 MW; 307E440877CCACE5 CRC64;
MIVNKKYFLL ICIIILISIN CLVLAKDEIE NFLKEGDDLV SKGKYDLANE NYSNAIDLIG
SDTQHPQYVS LLFKRAGIYH QKGKNILALS DLNRAIEANP DNIHARLKRA KIQSSLGRFE
EAMDEYKRVL KIRPDNSQAK QQIEKLKKVE QQLEKVRDMV KVEKNYKDSI AILLDIQSVV
SDLKEVRLML CECFFQQGDH RKVLDETMTI LKSEPSSVAA LYWRGKTFFS MGEKEIAMKF
LKEGLKFDPD NTNCRAMIKT INKFEKSTAN AQELFNQQKY QDALGQIEDA LEIEPNSPTH
STPLYLLKCK CLLKVKKGKE SIEACNRALE LDELNADALY NRAEAYMYEE DYQKALNDYN
KAREHKPNDP QIHDGIRRAQ KAQQMAKRKD YYKILGIQKS ATPEEIKKAF KKLAIKNHPD
KSTETDKEKA QQIYMDINEA YEALKDEEKR KRYDMGEDIN DPHGGQGGQG GGFGGFGGFH
GFQGFQGFQQ GGGGGGFQFH FR
