DNJC4_HUMAN
ID DNJC4_HUMAN Reviewed; 241 AA.
AC Q9NNZ3; O14716;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=DnaJ homolog subfamily C member 4;
DE AltName: Full=DnaJ-like protein HSPF2;
DE AltName: Full=Multiple endocrine neoplasia type 1 candidate protein number 18;
GN Name=DNAJC4; Synonyms=HSPF2, MCG18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9473517; DOI=10.1006/bbrc.1997.8091;
RA Silins G., Grimmond S., Hayward N.;
RT "Characterisation of a new human and murine member of the DnaJ family of
RT proteins.";
RL Biochem. Biophys. Res. Commun. 243:273-276(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RA Lloyd S.E., Thakker R.V.;
RT "Identification and characterisation of a novel human Dnaj gene, HSPF2,
RT mapping to chromosome 11q13.";
RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q9NNZ3; P42858: HTT; NbExp=12; IntAct=EBI-4397791, EBI-466029;
CC Q9NNZ3; O76024: WFS1; NbExp=3; IntAct=EBI-4397791, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB82426.1; Type=Miscellaneous discrepancy; Note=Several sequence rearrangements.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF036874; AAF97845.1; -; mRNA.
DR EMBL; BC044584; AAH44584.1; -; mRNA.
DR EMBL; BC057849; AAH57849.1; -; mRNA.
DR EMBL; AF012106; AAB82426.1; ALT_SEQ; mRNA.
DR CCDS; CCDS41666.1; -.
DR PIR; JE0169; JE0169.
DR RefSeq; NP_001294909.1; NM_001307980.1.
DR RefSeq; NP_001294910.1; NM_001307981.1.
DR RefSeq; NP_005519.2; NM_005528.3.
DR AlphaFoldDB; Q9NNZ3; -.
DR SMR; Q9NNZ3; -.
DR BioGRID; 109570; 56.
DR IntAct; Q9NNZ3; 3.
DR STRING; 9606.ENSP00000396896; -.
DR iPTMnet; Q9NNZ3; -.
DR PhosphoSitePlus; Q9NNZ3; -.
DR BioMuta; DNAJC4; -.
DR DMDM; 18203312; -.
DR MassIVE; Q9NNZ3; -.
DR PaxDb; Q9NNZ3; -.
DR PeptideAtlas; Q9NNZ3; -.
DR PRIDE; Q9NNZ3; -.
DR ProteomicsDB; 81878; -.
DR Antibodypedia; 2326; 68 antibodies from 15 providers.
DR DNASU; 3338; -.
DR Ensembl; ENST00000321685.7; ENSP00000396896.2; ENSG00000110011.14.
DR Ensembl; ENST00000628077.3; ENSP00000486499.2; ENSG00000110011.14.
DR GeneID; 3338; -.
DR KEGG; hsa:3338; -.
DR MANE-Select; ENST00000628077.3; ENSP00000486499.2; NM_005528.4; NP_005519.2.
DR UCSC; uc001nys.4; human.
DR CTD; 3338; -.
DR DisGeNET; 3338; -.
DR GeneCards; DNAJC4; -.
DR HGNC; HGNC:5271; DNAJC4.
DR HPA; ENSG00000110011; Tissue enhanced (testis).
DR MIM; 604189; gene.
DR neXtProt; NX_Q9NNZ3; -.
DR OpenTargets; ENSG00000110011; -.
DR PharmGKB; PA27421; -.
DR VEuPathDB; HostDB:ENSG00000110011; -.
DR eggNOG; KOG0691; Eukaryota.
DR GeneTree; ENSGT00510000048574; -.
DR HOGENOM; CLU_081597_0_0_1; -.
DR InParanoid; Q9NNZ3; -.
DR OMA; EKDRAIT; -.
DR OrthoDB; 1330473at2759; -.
DR PhylomeDB; Q9NNZ3; -.
DR TreeFam; TF105163; -.
DR PathwayCommons; Q9NNZ3; -.
DR SignaLink; Q9NNZ3; -.
DR BioGRID-ORCS; 3338; 8 hits in 1078 CRISPR screens.
DR ChiTaRS; DNAJC4; human.
DR GenomeRNAi; 3338; -.
DR Pharos; Q9NNZ3; Tdark.
DR PRO; PR:Q9NNZ3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9NNZ3; protein.
DR Bgee; ENSG00000110011; Expressed in right testis and 158 other tissues.
DR ExpressionAtlas; Q9NNZ3; baseline and differential.
DR Genevisible; Q9NNZ3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
DR GO; GO:0006457; P:protein folding; NAS:UniProtKB.
DR GO; GO:0006986; P:response to unfolded protein; TAS:ProtInc.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Chaperone; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..241
FT /note="DnaJ homolog subfamily C member 4"
FT /id="PRO_0000071049"
FT TRANSMEM 156..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 34..99
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 88..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 241 AA; 27593 MW; EA186D2FA6C2E179 CRC64;
MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV KRAFFSKSKE
LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR SGSPPKSPRT TVHDKSAHQT
HSSWTPPNAQ YWSQFHSVRP QGPQLRQQQH KQNKQVLGYC LLLMLAGMGL HYIAFRKVKQ
MHLNFMDEKD RIITAFYNEA RARARANRGI LQQERQRLGQ RQPPPSEPTQ GPEIVPRGAG
P
