DNJC4_MOUSE
ID DNJC4_MOUSE Reviewed; 244 AA.
AC Q9D844; O70278;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 18-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=DnaJ homolog subfamily C member 4;
DE AltName: Full=Multiple endocrine neoplasia type 1 candidate protein number 18 homolog;
GN Name=Dnajc4; Synonyms=Mcg18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9473517; DOI=10.1006/bbrc.1997.8091;
RA Silins G., Grimmond S., Hayward N.;
RT "Characterisation of a new human and murine member of the DnaJ family of
RT proteins.";
RL Biochem. Biophys. Res. Commun. 243:273-276(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AF036875; AAC40117.1; -; mRNA.
DR EMBL; AK008507; BAB25707.1; -; mRNA.
DR CCDS; CCDS50374.1; -.
DR PIR; JE0170; JE0170.
DR RefSeq; NP_065591.1; NM_020566.1.
DR AlphaFoldDB; Q9D844; -.
DR SMR; Q9D844; -.
DR STRING; 10090.ENSMUSP00000025915; -.
DR iPTMnet; Q9D844; -.
DR PhosphoSitePlus; Q9D844; -.
DR MaxQB; Q9D844; -.
DR PaxDb; Q9D844; -.
DR PRIDE; Q9D844; -.
DR ProteomicsDB; 277353; -.
DR Antibodypedia; 2326; 68 antibodies from 15 providers.
DR DNASU; 57431; -.
DR Ensembl; ENSMUST00000179118; ENSMUSP00000136062; ENSMUSG00000024963.
DR GeneID; 57431; -.
DR KEGG; mmu:57431; -.
DR UCSC; uc008gjx.1; mouse.
DR CTD; 3338; -.
DR MGI; MGI:1927346; Dnajc4.
DR VEuPathDB; HostDB:ENSMUSG00000024963; -.
DR eggNOG; KOG0691; Eukaryota.
DR GeneTree; ENSGT00510000048574; -.
DR InParanoid; Q9D844; -.
DR OMA; EKDRAIT; -.
DR OrthoDB; 1330473at2759; -.
DR PhylomeDB; Q9D844; -.
DR BioGRID-ORCS; 57431; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q9D844; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9D844; protein.
DR Bgee; ENSMUSG00000024963; Expressed in interventricular septum and 255 other tissues.
DR ExpressionAtlas; Q9D844; baseline and differential.
DR Genevisible; Q9D844; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..244
FT /note="DnaJ homolog subfamily C member 4"
FT /id="PRO_0000071050"
FT TRANSMEM 159..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 37..102
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 96..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 126
FT /note="S -> SS (in Ref. 2; BAB25707)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 244 AA; 28206 MW; 6FD655183A54840F CRC64;
MPSLLLQLPL RLCRLWPHSL SIRLLTAATG QRSVPTNYYE LLGVHPGASA EEIKRAFFTK
SKELHPDRDP GNPALHSRFV ELNEAYRVLS REESRRNYDH QLHSASPPKS SGSTAEPKYT
QQTHSSWEPP NAQYWAQFHS VRPQGPESRK QQRKHNQRVL GYCLLLMVAG MGLHYVAFRK
LEQVHRSFMD EKDRIITAIY NDTRARARAN RARIQQERQQ RQQPRAEPSL PPESSRIMPQ
DTSP
