ID   DNJC8_RAT               Reviewed;         253 AA.
AC   Q642C0;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=DnaJ homolog subfamily C member 8;
GN   Name=Dnajc8;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Suppresses polyglutamine (polyQ) aggregation of ATXN3 in
CC       neuronal cells. {ECO:0000250|UniProtKB:O75937}.
CC   -!- SUBUNIT: Interacts with SRPK1. Interacts with HSP70 (HSPA1A or HSPA1B).
CC       {ECO:0000250|UniProtKB:O75937}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O75937}.
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DR   EMBL; BC081863; AAH81863.1; -; mRNA.
DR   RefSeq; NP_001013186.1; NM_001013168.1.
DR   AlphaFoldDB; Q642C0; -.
DR   SMR; Q642C0; -.
DR   STRING; 10116.ENSRNOP00000017740; -.
DR   iPTMnet; Q642C0; -.
DR   PhosphoSitePlus; Q642C0; -.
DR   jPOST; Q642C0; -.
DR   PaxDb; Q642C0; -.
DR   PRIDE; Q642C0; -.
DR   Ensembl; ENSRNOT00000017740; ENSRNOP00000017740; ENSRNOG00000013255.
DR   GeneID; 313035; -.
DR   KEGG; rno:313035; -.
DR   UCSC; RGD:1306024; rat.
DR   CTD; 22826; -.
DR   RGD; 1306024; Dnajc8.
DR   eggNOG; KOG1150; Eukaryota.
DR   GeneTree; ENSGT00390000012569; -.
DR   HOGENOM; CLU_070940_2_0_1; -.
DR   InParanoid; Q642C0; -.
DR   OrthoDB; 1434217at2759; -.
DR   PhylomeDB; Q642C0; -.
DR   Reactome; R-RNO-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q642C0; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000013255; Expressed in thymus and 20 other tissues.
DR   ExpressionAtlas; Q642C0; baseline and differential.
DR   Genevisible; Q642C0; RN.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0030544; F:Hsp70 protein binding; ISO:RGD.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR042858; DNAJC8.
DR   InterPro; IPR036869; J_dom_sf.
DR   PANTHER; PTHR15606; PTHR15606; 1.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Chaperone; Nucleus; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O75937"
FT   CHAIN           2..253
FT                   /note="DnaJ homolog subfamily C member 8"
FT                   /id="PRO_0000071062"
FT   DOMAIN          68..135
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   REGION          181..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..253
FT                   /note="Essential for polyglutamine aggregation suppression"
FT                   /evidence="ECO:0000250|UniProtKB:O75937"
FT   MOTIF           189..192
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:O75937"
FT   MOTIF           203..206
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:O75937"
FT   COMPBIAS        181..221
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:O75937"
FT   MOD_RES         35
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75937"
FT   MOD_RES         146
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:O75937"
FT   MOD_RES         222
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75937"
SQ   SEQUENCE   253 AA;  29813 MW;  295D0C3F0B2A0F49 CRC64;
     MAASGESGAS GGGGSTEEAF MTFYSEVKQI EKRDSVLTSK NQIERLTRPG SSYFNLNPFE
     VLQIDPEVTD EEIKKRFRQL SILVHPDKNQ DDADRAQKAF EAVDKAYKLL LDQEQKKRAL
     DVIQAGKEYV EHTVKERKKQ LKKEGKPTNV EEDDPELFKQ AVYKQTMKLF AELEIKRKER
     EAKEMHERKR QREEEIEAQE KAKREREWQK NFEESRDGRV DSWRNFQANT KGKKEKKNRT
     FLRPPKVKME QRE