ID   DNRI_STRPE              Reviewed;         272 AA.
AC   P25047;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Regulatory protein DnrI;
GN   Name=dnrI;
OS   Streptomyces peucetius.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1950;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29050 / DSM 40754 / JCM 9920 / NBRC 100596 / NCIMB 10972;
RX   PubMed=1729206; DOI=10.1128/jb.174.1.144-154.1992;
RA   Stutzman-Engwall K.J., Otten S.L., Hutchinson C.R.;
RT   "Regulation of secondary metabolism in Streptomyces spp. and overproduction
RT   of daunorubicin in Streptomyces peucetius.";
RL   J. Bacteriol. 174:144-154(1992).
CC   -!- FUNCTION: May form, with DnrJ a two-component regulatory system for
CC       daunorubicin biosynthesis genes.
CC   -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; M80237; AAA26736.1; -; Genomic_DNA.
DR   PIR; A43306; A43306.
DR   AlphaFoldDB; P25047; -.
DR   SMR; P25047; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd15831; BTAD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03704; BTAD; 1.
DR   SMART; SM01043; BTAD; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; DNA-binding; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..272
FT                   /note="Regulatory protein DnrI"
FT                   /id="PRO_0000110005"
FT   DNA_BIND        1..100
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
SQ   SEQUENCE   272 AA;  29698 MW;  97B59E1175030D93 CRC64;
     MQINMLGPLV AHHNGTSVTP IARKPRQVFS LLALQAGTVV PVPALMDELW GTQPPASALT
     TLQTYILQVR RGITVALGAS HNGPAKDVLR TCYGGYLLDV DPTNTDVYAF ERLAEEGKRA
     CERGELDLAS ARFRQALDLW RGDALVDVHA GMRIGMEVAR LEESRLGVLE ARMETDLRLG
     RHAGLLPELS ALTARHPMHE NLWAQFMIAL HRSGRTSQAL EAFIKLRKTL VNELGVEPSA
     RLQHLQHAIL RADPGIDRNG PEVPAAASVA LA