ID   DNRV_STRS5              Reviewed;         275 AA.
AC   Q55078;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Anthracycline biosynthesis protein DauV;
GN   Name=dauV;
OS   Streptomyces sp. (strain C5).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=45212;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C5;
RX   PubMed=8655530; DOI=10.1128/jb.178.11.3389-3395.1996;
RA   Dickens M.L., Strohl W.R.;
RT   "Isolation and characterization of a gene from Streptomyces sp. strain C5
RT   that confers the ability to convert daunomycin to doxorubicin on
RT   Streptomyces lividans TK24.";
RL   J. Bacteriol. 178:3389-3395(1996).
CC   -!- FUNCTION: Involved in the biosynthesis of the anthracyclines
CC       carminomycin and daunorubicin (daunomycin) which are aromatic
CC       polyketide antibiotics that exhibit high cytotoxicity and are widely
CC       applied in the chemotherapy of a variety of cancers. Acts jointly with
CC       DoxA in the conversion of 13-deoxycarminomycin and 13-deoxydaunorubicin
CC       to yield carminomycin and daunorubicin, respectively (By similarity).
CC       {ECO:0000250}.
CC   -!- PATHWAY: Antibiotic biosynthesis; daunorubicin biosynthesis.
CC   -!- PATHWAY: Antibiotic biosynthesis; carminomycin biosynthesis.
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DR   EMBL; U50973; AAB08048.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q55078; -.
DR   SMR; Q55078; -.
DR   UniPathway; UPA00054; -.
DR   UniPathway; UPA01040; -.
DR   GO; GO:1901771; P:daunorubicin biosynthetic process; ISS:UniProtKB.
DR   Gene3D; 3.10.180.10; -; 2.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR041581; Glyoxalase_6.
DR   InterPro; IPR037523; VOC.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   Pfam; PF18029; Glyoxalase_6; 1.
DR   SUPFAM; SSF54593; SSF54593; 2.
DR   PROSITE; PS51819; VOC; 2.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Repeat.
FT   CHAIN           1..275
FT                   /note="Anthracycline biosynthesis protein DauV"
FT                   /id="PRO_0000425687"
FT   DOMAIN          8..136
FT                   /note="VOC 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   DOMAIN          150..263
FT                   /note="VOC 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
SQ   SEQUENCE   275 AA;  28840 MW;  BCDD9BEA60BDE4AF CRC64;
     MTRFAPGAPA WFDLGSPDVA ASADFYTGLF GWTATVVSDP GAGGYTTFSS DGKLVAAVAR
     HQIDTPYHRP YGPGNDQHGM PAIWTVYFAT NDADALTKRV ETAGGDVIMT PMDVLGLGRM
     AVFADPSGAA FAVWRKGVME GAEVTGVPGS VGWVELVTDD IGTARGFYRA TLGLAPADTG
     RKGVTDPVWH IHDTPVAGTR ELGTTGAVRP HWAVLFSVHD CDATVRRAVE LGGSVENEPV
     DTPRGRRADL LDPHGAGFSV VELREAYPAA ADGAS