ID   DNSL1_BOVIN             Reviewed;         316 AA.
AC   Q2QDE9;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Deoxyribonuclease-1-like 1;
DE            EC=3.1.21.-;
DE   AltName: Full=DNase X;
DE   AltName: Full=Deoxyribonuclease I-like 1;
DE            Short=DNase I-like 1;
DE   Flags: Precursor;
GN   Name=DNASE1L1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16107205; DOI=10.1042/bj20051114;
RA   Shiokawa D., Shika Y., Saito K., Yamazaki K., Tanuma S.;
RT   "Physical and biochemical properties of mammalian DNase X proteins: non-AUG
RT   translation initiation of porcine and bovine mRNAs for DNase X.";
RL   Biochem. J. 392:511-517(2005).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNase I family. {ECO:0000305}.
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DR   EMBL; DQ116783; AAZ94276.1; -; mRNA.
DR   RefSeq; NP_001033723.1; NM_001038634.1.
DR   AlphaFoldDB; Q2QDE9; -.
DR   SMR; Q2QDE9; -.
DR   STRING; 9913.ENSBTAP00000009806; -.
DR   PaxDb; Q2QDE9; -.
DR   GeneID; 515176; -.
DR   KEGG; bta:515176; -.
DR   CTD; 1774; -.
DR   eggNOG; ENOG502QPNY; Eukaryota.
DR   InParanoid; Q2QDE9; -.
DR   OrthoDB; 1282784at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004530; F:deoxyribonuclease I activity; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0006308; P:DNA catabolic process; IBA:GO_Central.
DR   GO; GO:0000737; P:DNA catabolic process, endonucleolytic; IBA:GO_Central.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR018057; Deoxyribonuclease-1_AS.
DR   InterPro; IPR016202; DNase_I.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   PIRSF; PIRSF000988; DNase_I_euk; 1.
DR   PRINTS; PR00130; DNASEI.
DR   SMART; SM00476; DNaseIc; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   PROSITE; PS00919; DNASE_I_1; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Endonuclease; Endoplasmic reticulum; Glycoprotein;
KW   Hydrolase; Nuclease; Reference proteome; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..316
FT                   /note="Deoxyribonuclease-1-like 1"
FT                   /id="PRO_0000231030"
FT   ACT_SITE        107
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        158
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        271
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        197..234
FT                   /note="Essential for enzymatic activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   316 AA;  35168 MW;  6104CA80DD21E842 CRC64;
     MHSSGGFQKA IHGHALLLLL LLASGAETFR ICAFNAQRLT LAKVAREPVL DTLVKILARC
     DIMVLQEVVD SSDTAIPLLL RELNRFGDSG PYASHSSLLL GRSTYKEKYV YLYRSHEAEV
     RDSYMYDDQD DLFTREPFVC WFSLRSKVLP SLVLVPLHTT PKAVETELNA LYDVFLDASG
     RWQTKDVILL GDFNADCTSL TKKRLDDLVL RTQAGFHWAI ADGVDTTVRA STHCTYDRIV
     LHGELLQSLL RGAAAFDFPQ SFGLTEQEAL NISDHYPVEV DLALSWAVHG VQPPCLATLW
     LSLLLPLLAP QLGLVA