DNSL1_CRIGR
ID DNSL1_CRIGR Reviewed; 304 AA.
AC Q2QDE6;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Deoxyribonuclease-1-like 1;
DE EC=3.1.21.-;
DE AltName: Full=DNase X;
DE AltName: Full=Deoxyribonuclease I-like 1;
DE Short=DNase I-like 1;
DE Flags: Precursor;
GN Name=DNASE1L1;
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16107205; DOI=10.1042/bj20051114;
RA Shiokawa D., Shika Y., Saito K., Yamazaki K., Tanuma S.;
RT "Physical and biochemical properties of mammalian DNase X proteins: non-AUG
RT translation initiation of porcine and bovine mRNAs for DNase X.";
RL Biochem. J. 392:511-517(2005).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNase I family. {ECO:0000305}.
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DR EMBL; DQ116786; AAZ94279.1; -; mRNA.
DR RefSeq; NP_001231047.1; NM_001244118.1.
DR AlphaFoldDB; Q2QDE6; -.
DR SMR; Q2QDE6; -.
DR STRING; 10029.NP_001231047.1; -.
DR Ensembl; ENSCGRT00001025114; ENSCGRP00001020870; ENSCGRG00001019882.
DR GeneID; 100689095; -.
DR KEGG; cge:100689095; -.
DR CTD; 1774; -.
DR eggNOG; ENOG502QQFT; Eukaryota.
DR GeneTree; ENSGT00950000182846; -.
DR OMA; FHWAIAD; -.
DR OrthoDB; 1282784at2759; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0004536; F:deoxyribonuclease activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006308; P:DNA catabolic process; IEA:InterPro.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR018057; Deoxyribonuclease-1_AS.
DR InterPro; IPR016202; DNase_I.
DR InterPro; IPR033125; DNASE_I_2.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR PIRSF; PIRSF000988; DNase_I_euk; 1.
DR PRINTS; PR00130; DNASEI.
DR SMART; SM00476; DNaseIc; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
DR PROSITE; PS00919; DNASE_I_1; 1.
DR PROSITE; PS00918; DNASE_I_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Endonuclease; Endoplasmic reticulum; Glycoprotein;
KW Hydrolase; Nuclease; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..304
FT /note="Deoxyribonuclease-1-like 1"
FT /id="PRO_0000231032"
FT ACT_SITE 103
FT /evidence="ECO:0000250"
FT ACT_SITE 154
FT /evidence="ECO:0000250"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 123
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 229
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 193..230
FT /note="Essential for enzymatic activity"
FT /evidence="ECO:0000250"
SQ SEQUENCE 304 AA; 34359 MW; 2407DD997CF25B26 CRC64;
MPYMAMHGLT VALLLIFLAG GTEAFRICAF NAQRLTLSKL AKEPVMDTLV QILARCDIMV
LQEVVDSSQK TVSLLLRELN RFDSSRTYSF LNSSLLGRST YKEKYVYIYR SDKTQILNSY
QYNDTNDLFA REPFVAQFAL PSKILPSVVL VPLHTTPKDV EKELNALYDV FLDVSQRWQN
EDVILLGDFN ADCASLTKKR LNSLLLRTEA GFHWVISDGE DTTVRASTNC TYDRIVMHGQ
GCQTLLRAAA PFNFPRSFQL TEEEALSISD HYPVEVELSQ ATHNIQLFSL AILLLLSLLP
SQLS
