DOA_HUMAN
ID DOA_HUMAN Reviewed; 250 AA.
AC P06340; Q58HU0; Q58HU1; Q5STC7; Q9TQC6; Q9TQC7; Q9TQC8; Q9TQC9; Q9TQD0;
AC Q9TQD1; Q9TQD2; Q9TQD3;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=HLA class II histocompatibility antigen, DO alpha chain;
DE AltName: Full=MHC DN-alpha;
DE AltName: Full=MHC DZ alpha;
DE AltName: Full=MHC class II antigen DOA;
DE Flags: Precursor;
GN Name=HLA-DOA; Synonyms=HLA-DNA, HLA-DZA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DOA*01:01).
RX PubMed=3000765; DOI=10.1002/j.1460-2075.1985.tb03919.x;
RA Trowsdale J., Kelly A.;
RT "The human HLA class II alpha chain gene DZ alpha is distinct from genes in
RT the DP, DQ and DR subregions.";
RL EMBO J. 4:2231-2237(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DOA*01:01).
RX PubMed=2499532; DOI=10.1007/bf00375872;
RA Jonsson A.-K., Rask L.;
RT "Human class II DNA and DOB genes display low sequence variability.";
RL Immunogenetics 29:411-413(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DOA*01:01).
RX PubMed=2370084; DOI=10.1007/bf02115015;
RA Young J.A., Trowsdale J.;
RT "The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA
RT transcript.";
RL Immunogenetics 31:386-388(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DOA*01:01; DOA*01:02 AND DOA*01:03).
RX PubMed=16101837; DOI=10.1111/j.1399-0039.2005.00446.x;
RA Moon S.-M., Gu H., Ryu H.-J., Kim J.-J., Kim H.-T., Han B.G., Kimm K.,
RA Lee J.-K., Oh B.;
RT "Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102,
RT DOA*0103, and DOA*0104N, by sequence-based typing.";
RL Tissue Antigens 66:242-245(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DOA*01:01).
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DOA*01:01).
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DOA*01:01).
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DOA*01:01).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-250 (ALLELE DOA*01:01).
RX PubMed=10323340; DOI=10.1034/j.1399-0039.1999.530406.x;
RA Naruse T.K., Kawata H., Anzai T., Takashige N., Kagiya M., Nose Y.,
RA Nabeya N., Isshiki G., Tatsumi N., Inoko H.;
RT "Limited polymorphism in the HLA-DOA gene.";
RL Tissue Antigens 53:359-365(1999).
RN [10]
RP REVIEW.
RX PubMed=10837054; DOI=10.1146/annurev.immunol.18.1.113;
RA Alfonso C., Karlsson L.;
RT "Nonclassical MHC class II molecules.";
RL Annu. Rev. Immunol. 18:113-142(2000).
CC -!- FUNCTION: Important modulator in the HLA class II restricted antigen
CC presentation pathway by interaction with the HLA-DM molecule in B-
CC cells. Modifies peptide exchange activity of HLA-DM.
CC -!- SUBUNIT: Heterodimer of an alpha chain (DOA) and a beta chain (DOB).
CC Forms a heterotetrameric complex with an HLA-DM molecule during
CC intracellular transport in endosomal/lysosomal compartments in B-cells.
CC -!- INTERACTION:
CC P06340; Q04864: REL; NbExp=3; IntAct=EBI-10194851, EBI-307352;
CC -!- SUBCELLULAR LOCATION: Endosome membrane; Single-pass type I membrane
CC protein. Lysosome membrane; Single-pass type I membrane protein.
CC Note=Complexes with HLA-DM molecule during intracellular transport and
CC in endosomal/lysosomal compartments. Heterotetramerization is necessary
CC to exit the ER.
CC -!- POLYMORPHISM: The following alleles of DOA are known: DOA*01:01,
CC DOA*01:02 and DOA*01:03. The sequence shown is that of DOA*01:01.
CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR EMBL; X02882; CAA26635.1; -; Genomic_DNA.
DR EMBL; M26039; AAA59716.1; -; mRNA.
DR EMBL; M31525; AAA60075.1; -; mRNA.
DR EMBL; AY947479; AAX49509.1; -; mRNA.
DR EMBL; AY947480; AAX49510.1; -; mRNA.
DR EMBL; AY947481; AAX49511.1; -; mRNA.
DR EMBL; AK290714; BAF83403.1; -; mRNA.
DR EMBL; AK313551; BAG36327.1; -; mRNA.
DR EMBL; Z81310; CAB03594.1; -; Genomic_DNA.
DR EMBL; AL662845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL645931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL805913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX005422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR936909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03668.1; -; Genomic_DNA.
DR EMBL; BC013183; AAH13183.1; -; mRNA.
DR EMBL; AB005991; BAA81787.1; -; Genomic_DNA.
DR EMBL; AB005992; BAA81788.1; -; Genomic_DNA.
DR EMBL; AB005993; BAA81789.1; -; Genomic_DNA.
DR EMBL; AB005994; BAA81790.1; -; Genomic_DNA.
DR EMBL; AB005995; BAA81791.1; -; Genomic_DNA.
DR EMBL; AB005996; BAA81792.1; -; Genomic_DNA.
DR EMBL; AB005997; BAA81793.1; -; Genomic_DNA.
DR EMBL; AB005998; BAA81794.1; -; Genomic_DNA.
DR CCDS; CCDS4763.1; -.
DR PIR; A02216; HLHUDZ.
DR RefSeq; NP_002110.1; NM_002119.3.
DR PDB; 4I0P; X-ray; 3.20 A; C/G=27-207.
DR PDBsum; 4I0P; -.
DR AlphaFoldDB; P06340; -.
DR SMR; P06340; -.
DR BioGRID; 109356; 4.
DR DIP; DIP-60116N; -.
DR IntAct; P06340; 6.
DR STRING; 9606.ENSP00000229829; -.
DR GlyGen; P06340; 2 sites.
DR iPTMnet; P06340; -.
DR PhosphoSitePlus; P06340; -.
DR BioMuta; HLA-DOA; -.
DR DMDM; 122210; -.
DR EPD; P06340; -.
DR jPOST; P06340; -.
DR MassIVE; P06340; -.
DR PaxDb; P06340; -.
DR PeptideAtlas; P06340; -.
DR PRIDE; P06340; -.
DR ProteomicsDB; 51896; -.
DR Antibodypedia; 28851; 155 antibodies from 25 providers.
DR DNASU; 3111; -.
DR Ensembl; ENST00000229829.7; ENSP00000229829.3; ENSG00000204252.14.
DR Ensembl; ENST00000383226.4; ENSP00000372713.4; ENSG00000206292.13.
DR Ensembl; ENST00000426070.2; ENSP00000401504.2; ENSG00000231558.11.
DR Ensembl; ENST00000426685.2; ENSP00000397945.2; ENSG00000232957.11.
DR Ensembl; ENST00000434335.2; ENSP00000416448.2; ENSG00000232962.11.
DR Ensembl; ENST00000438987.2; ENSP00000395737.2; ENSG00000230141.11.
DR Ensembl; ENST00000452598.2; ENSP00000398819.2; ENSG00000235744.11.
DR GeneID; 3111; -.
DR KEGG; hsa:3111; -.
DR MANE-Select; ENST00000229829.7; ENSP00000229829.3; NM_002119.4; NP_002110.1.
DR CTD; 3111; -.
DR DisGeNET; 3111; -.
DR GeneCards; HLA-DOA; -.
DR HGNC; HGNC:4936; HLA-DOA.
DR HPA; ENSG00000204252; Tissue enhanced (lymphoid).
DR MIM; 142930; gene.
DR neXtProt; NX_P06340; -.
DR OpenTargets; ENSG00000204252; -.
DR PharmGKB; PA35060; -.
DR VEuPathDB; HostDB:ENSG00000204252; -.
DR eggNOG; ENOG502RXYJ; Eukaryota.
DR GeneTree; ENSGT00940000162112; -.
DR HOGENOM; CLU_069380_0_0_1; -.
DR InParanoid; P06340; -.
DR OMA; ASIAMIR; -.
DR OrthoDB; 1132781at2759; -.
DR PhylomeDB; P06340; -.
DR TreeFam; TF333797; -.
DR PathwayCommons; P06340; -.
DR Reactome; R-HSA-2132295; MHC class II antigen presentation.
DR SignaLink; P06340; -.
DR SIGNOR; P06340; -.
DR BioGRID-ORCS; 3111; 12 hits in 1061 CRISPR screens.
DR GeneWiki; HLA-DOA; -.
DR GenomeRNAi; 3111; -.
DR Pharos; P06340; Tbio.
DR PRO; PR:P06340; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P06340; protein.
DR Bgee; ENSG00000204252; Expressed in lymph node and 103 other tissues.
DR ExpressionAtlas; P06340; baseline and differential.
DR Genevisible; P06340; HS.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; TAS:Reactome.
DR GO; GO:0042613; C:MHC class II protein complex; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:ProtInc.
DR GO; GO:0023026; F:MHC class II protein complex binding; IDA:UniProtKB.
DR GO; GO:0032395; F:MHC class II receptor activity; TAS:UniProtKB.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0002587; P:negative regulation of antigen processing and presentation of peptide antigen via MHC class II; IDA:UniProtKB.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR GO; GO:0045580; P:regulation of T cell differentiation; IEA:Ensembl.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.320.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Disulfide bond; Endosome; Glycoprotein;
KW Immunity; Lysosome; Membrane; MHC II; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..250
FT /note="HLA class II histocompatibility antigen, DO alpha
FT chain"
FT /id="PRO_0000018962"
FT TOPO_DOM 26..217
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 113..205
FT /note="Ig-like C1-type"
FT REGION 26..110
FT /note="Alpha-1"
FT REGION 111..204
FT /note="Alpha-2"
FT REGION 205..217
FT /note="Connecting peptide"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 133..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 99
FT /note="L -> V (in allele DOA*01:03; dbSNP:rs41542323)"
FT /id="VAR_058126"
FT VARIANT 105
FT /note="R -> C (in allele DOA*01:02; dbSNP:rs11575906)"
FT /id="VAR_058127"
FT STRAND 29..40
FT /evidence="ECO:0007829|PDB:4I0P"
FT HELIX 42..44
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 45..52
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 55..61
FT /evidence="ECO:0007829|PDB:4I0P"
FT TURN 62..65
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 66..71
FT /evidence="ECO:0007829|PDB:4I0P"
FT HELIX 72..74
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 77..80
FT /evidence="ECO:0007829|PDB:4I0P"
FT HELIX 87..94
FT /evidence="ECO:0007829|PDB:4I0P"
FT HELIX 96..102
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 114..121
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 129..141
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 144..149
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 152..154
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 171..179
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 187..192
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 196..198
FT /evidence="ECO:0007829|PDB:4I0P"
FT STRAND 200..204
FT /evidence="ECO:0007829|PDB:4I0P"
SQ SEQUENCE 250 AA; 27599 MW; FA9482197A02AC85 CRC64;
MALRAGLVLG FHTLMTLLSP QEAGATKADH MGSYGPAFYQ SYGASGQFTH EFDEEQLFSV
DLKKSEAVWR LPEFGDFARF DPQGGLAGIA AIKAHLDILV ERSNRSRAIN VPPRVTVLPK
SRVELGQPNI LICIVDNIFP PVINITWLRN GQTVTEGVAQ TSFYSQPDHL FRKFHYLPFV
PSAEDVYDCQ VEHWGLDAPL LRHWELQVPI PPPDAMETLV CALGLAIGLV GFLVGTVLII
MGTYVSSVPR
