位置:首页 > 蛋白库 > DOB_PANTR
DOB_PANTR
ID   DOB_PANTR               Reviewed;         273 AA.
AC   P18467;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Patr class II histocompatibility antigen, DO beta chain;
DE   AltName: Full=ChLa class II histocompatibility antigen, DO beta chain;
DE   AltName: Full=MHC class II antigen DOB;
DE   Flags: Precursor;
GN   Name=Patr-DOB;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2744808; DOI=10.1007/bf02421475;
RA   Kasahara M., Klein D., Klein J.;
RT   "Nucleotide sequence of a chimpanzee DOB cDNA clone.";
RL   Immunogenetics 30:66-68(1989).
CC   -!- FUNCTION: Important modulator in the HLA class II restricted antigen
CC       presentation pathway by interaction with the HLA-DM molecule in B-
CC       cells. Modifies peptide exchange activity of HLA-DM.
CC   -!- SUBUNIT: Heterodimer of an alpha chain (DOA) and a beta chain (DOB).
CC       Forms a heterotetrameric complex with an HLA-DM molecule during
CC       intracellular transport in endosomal/lysosomal compartments in B-cells.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Single-pass type
CC       I membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}. Note=Complexes with
CC       HLA-DM molecule during intracellular transport and in
CC       endosomal/lysosomal compartments. Heterotetramerization is necessary to
CC       exit the ER.
CC   -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M24358; AAA35409.1; -; mRNA.
DR   PIR; A45879; A45879.
DR   RefSeq; NP_001123943.1; NM_001130471.1.
DR   AlphaFoldDB; P18467; -.
DR   SMR; P18467; -.
DR   STRING; 9598.ENSPTRP00000030772; -.
DR   PaxDb; P18467; -.
DR   GeneID; 471977; -.
DR   KEGG; ptr:471977; -.
DR   CTD; 471977; -.
DR   eggNOG; ENOG502RWX2; Eukaryota.
DR   InParanoid; P18467; -.
DR   OrthoDB; 1249505at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR   GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR   GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Disulfide bond; Endosome; Glycoprotein; Immunity;
KW   Lysosome; Membrane; MHC II; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..26
FT   CHAIN           27..273
FT                   /note="Patr class II histocompatibility antigen, DO beta
FT                   chain"
FT                   /id="PRO_0000018964"
FT   TOPO_DOM        27..224
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        246..273
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          123..213
FT                   /note="Ig-like C1-type"
FT   REGION          27..120
FT                   /note="Beta-1"
FT   REGION          121..214
FT                   /note="Beta-2"
FT   REGION          215..224
FT                   /note="Connecting peptide"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        41..105
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        143..199
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   273 AA;  30922 MW;  8AC0A1F56A06D30D CRC64;
     MGSGWVPWVV ALLVNLTRLD SSMTQGTDSP EDFVIQAKAD CYFTNGTEKV QFVVRFIFNL
     EEYVRFDSDV GMFVALTKLG QPDAEQWNSR LDLLERSRQA VDGVCRHNYR LGAPFTVGRK
     VQPEVTVYPE RTPLLHQHNL LHCSVTGFYP GDIKIRWFLN GQEERARVMS TGPIRNGDWT
     FQTVVMLEMT PELGHVYTCL VDHSSLLSPV SVEWRAQSEY SWKKMLSGIA AFLLGLIFLL
     VGIVIQLRAQ KGYVRTQMSG NEVSRAVLLP QSC
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024