DOC10_MOUSE
ID DOC10_MOUSE Reviewed; 2150 AA.
AC Q8BZN6; F1AHI9;
DT 03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Dedicator of cytokinesis protein 10 {ECO:0000305};
DE AltName: Full=Zizimin-3;
GN Name=Dock10 {ECO:0000312|MGI:MGI:2146320}; Synonyms=Kiaa0694, Ziz3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, AND INDUCTION
RP BY IL4.
RC STRAIN=BALB/cJ; TISSUE=Spleen;
RX PubMed=21514340; DOI=10.1016/j.humimm.2011.03.024;
RA Alcaraz-Garcia M.J., Ruiz-Lafuente N., Sebastian-Ruiz S., Majado M.J.,
RA Gonzalez-Garcia C., Bernardo M.V., Alvarez-Lopez M.R., Parrado A.;
RT "Human and mouse DOCK10 splicing isoforms with alternative first coding
RT exon usage are differentially expressed in T and B lymphocytes.";
RL Hum. Immunol. 72:531-537(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 348-2150 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1690-2150 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=15710388; DOI=10.1016/j.febslet.2005.01.006;
RA Nishikimi A., Meller N., Uekawa N., Isobe K., Schwartz M.A., Maruyama M.;
RT "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange
RT factor expressed predominantly in lymphocytes.";
RL FEBS Lett. 579:1039-1046(2005).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-877; SER-1251; SER-1257;
RP SER-1292; SER-1295 AND THR-1440, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-196; SER-302; THR-368;
RP SER-1257; SER-1292; SER-1295; SER-1318 AND THR-1406, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [8]
RP DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=25729399; DOI=10.1186/s12979-015-0028-x;
RA Matsuda T., Yanase S., Takaoka A., Maruyama M.;
RT "The immunosenescence-related gene Zizimin2 is associated with early bone
RT marrow B cell development and marginal zone B cell formation.";
RL Immun. Ageing 12:1-1(2015).
RN [9]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION,
RP AND DOMAIN.
RX PubMed=25851601; DOI=10.1091/mbc.e14-08-1310;
RA Jaudon F., Raynaud F., Wehrle R., Bellanger J.M., Doulazmi M., Vodjdani G.,
RA Gasman S., Fagni L., Dusart I., Debant A., Schmidt S.;
RT "The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.";
RL Mol. Biol. Cell 26:2112-2127(2015).
RN [10]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=27502165; DOI=10.1016/j.imbio.2016.07.015;
RA Garcia-Serna A.M., Alcaraz-Garcia M.J., Ruiz-Lafuente N.,
RA Sebastian-Ruiz S., Martinez C.M., Moya-Quiles M.R., Minguela A.,
RA Garcia-Alonso A.M., Martin-Orozco E., Parrado A.;
RT "Dock10 regulates CD23 expression and sustains B-cell lymphopoiesis in
RT secondary lymphoid tissue.";
RL Immunobiology 221:1343-1350(2016).
CC -!- FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42
CC and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic
CC spine morphogenesis in Purkinje cells and in hippocampal neurons, via a
CC CDC42-mediated pathway (PubMed:25851601). Sustains B-cell lymphopoiesis
CC in secondary lymphoid tissues and regulates FCER2/CD23 expression
CC (PubMed:27502165). {ECO:0000269|PubMed:25851601,
CC ECO:0000269|PubMed:27502165}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96BY6}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q96BY6}. Cell projection, dendritic spine
CC {ECO:0000269|PubMed:25851601}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=DOCK10.1 {ECO:0000303|PubMed:21514340};
CC IsoId=Q8BZN6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BZN6-2; Sequence=VSP_007718, VSP_022288;
CC Name=3;
CC IsoId=Q8BZN6-3; Sequence=VSP_007718, VSP_022227;
CC Name=4; Synonyms=DOCK10.2 {ECO:0000303|PubMed:21514340};
CC IsoId=Q8BZN6-4; Sequence=VSP_058821, VSP_058822;
CC -!- TISSUE SPECIFICITY: Expressed in brain, lung, spleen, mesenteric lymph
CC nodes (MLN) and thymus (PubMed:15710388, PubMed:25729399). Expressed by
CC B and T splenocytes (PubMed:21514340). In brain, expressed by Purkinje
CC cells during postnatal development and hippocampal neurons
CC (PubMed:25851601). {ECO:0000269|PubMed:15710388,
CC ECO:0000269|PubMed:21514340, ECO:0000269|PubMed:25729399,
CC ECO:0000269|PubMed:25851601}.
CC -!- DEVELOPMENTAL STAGE: At early postnatal stages, expressed broadly in
CC the cerebellum and from P15 the expression becomes restricted to
CC Purkinje cells. {ECO:0000269|PubMed:25851601}.
CC -!- INDUCTION: Isoform 4 (but not isoform 1) is highly induced by IL4 in B
CC splenocytes, but not T splenocytes. {ECO:0000269|PubMed:21514340}.
CC -!- DOMAIN: The DOCKER domain may mediate some GEF activity.
CC {ECO:0000269|PubMed:25851601}.
CC -!- DISRUPTION PHENOTYPE: Knockout mice are viable and fertile
CC (PubMed:25729399, PubMed:27502165). They show decreased numbers of B-
CC cells in spleen, both follicular B-cells and marginal zone B-cells, and
CC in peripheral blood, but not in bone marrow (PubMed:25729399,
CC PubMed:27502165). Their percentage of splenic CD8(+) T-cells is
CC decreased comparing to wild types (PubMed:25729399).
CC {ECO:0000269|PubMed:25729399, ECO:0000269|PubMed:27502165}.
CC -!- MISCELLANEOUS: 'Zizim' means 'spike' in Hebrew. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000255|PROSITE-
CC ProRule:PRU00983}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC28567.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GU797481; ADK73961.1; -; mRNA.
DR EMBL; AC124672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC132387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK122347; BAC65629.1; -; mRNA.
DR EMBL; AK034064; BAC28567.1; ALT_INIT; mRNA.
DR RefSeq; NP_001272856.1; NM_001285927.1.
DR RefSeq; NP_780500.2; NM_175291.4.
DR AlphaFoldDB; Q8BZN6; -.
DR SMR; Q8BZN6; -.
DR BioGRID; 229145; 6.
DR IntAct; Q8BZN6; 4.
DR MINT; Q8BZN6; -.
DR STRING; 10090.ENSMUSP00000077099; -.
DR iPTMnet; Q8BZN6; -.
DR PhosphoSitePlus; Q8BZN6; -.
DR SwissPalm; Q8BZN6; -.
DR EPD; Q8BZN6; -.
DR jPOST; Q8BZN6; -.
DR MaxQB; Q8BZN6; -.
DR PaxDb; Q8BZN6; -.
DR PeptideAtlas; Q8BZN6; -.
DR PRIDE; Q8BZN6; -.
DR ProteomicsDB; 279750; -. [Q8BZN6-1]
DR ProteomicsDB; 279751; -. [Q8BZN6-2]
DR ProteomicsDB; 279752; -. [Q8BZN6-3]
DR ProteomicsDB; 279753; -. [Q8BZN6-4]
DR GeneID; 210293; -.
DR KEGG; mmu:210293; -.
DR UCSC; uc007brf.1; mouse. [Q8BZN6-2]
DR CTD; 55619; -.
DR MGI; MGI:2146320; Dock10.
DR eggNOG; KOG1997; Eukaryota.
DR InParanoid; Q8BZN6; -.
DR OrthoDB; 20156at2759; -.
DR PhylomeDB; Q8BZN6; -.
DR Reactome; R-MMU-9013148; CDC42 GTPase cycle.
DR Reactome; R-MMU-9013149; RAC1 GTPase cycle.
DR Reactome; R-MMU-9013404; RAC2 GTPase cycle.
DR Reactome; R-MMU-9013423; RAC3 GTPase cycle.
DR Reactome; R-MMU-983231; Factors involved in megakaryocyte development and platelet production.
DR BioGRID-ORCS; 210293; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Dock10; mouse.
DR PRO; PR:Q8BZN6; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8BZN6; protein.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0043197; C:dendritic spine; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; IPI:MGI.
DR GO; GO:0001782; P:B cell homeostasis; IMP:UniProtKB.
DR GO; GO:0060997; P:dendritic spine morphogenesis; IMP:UniProtKB.
DR GO; GO:0002315; P:marginal zone B cell differentiation; IMP:UniProtKB.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IDA:UniProtKB.
DR GO; GO:0030334; P:regulation of cell migration; ISO:MGI.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; PTHR23317; 1.
DR Pfam; PF06920; DHR-2; 2.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DUF3398; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cell projection; Cytoplasm;
KW Guanine-nucleotide releasing factor; Nucleus; Phosphoprotein;
KW Reference proteome; Synapse.
FT CHAIN 1..2150
FT /note="Dedicator of cytokinesis protein 10"
FT /id="PRO_0000190003"
FT DOMAIN 181..290
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 672..850
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00983"
FT DOMAIN 1690..2150
FT /note="DOCKER"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00984"
FT REGION 141..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 196
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 302
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 368
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 834
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q96BY6"
FT MOD_RES 877
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 1232
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96BY6"
FT MOD_RES 1251
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 1257
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1292
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1295
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1318
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1406
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1440
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT VAR_SEQ 1..42
FT /note="MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQ -> MSFRGK
FT EFWKRRRTVKRVNPEGIHKAGAQ (in isoform 4)"
FT /id="VSP_058821"
FT VAR_SEQ 1739..1771
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:12693553,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_007718"
FT VAR_SEQ 2150
FT /note="Q -> LCRGPCLYSFCASVSSISLSTVSKSDYGQGRPSKVRSGATLHHTCNQ
FT GDRGCTCGLHLIQCGGLRGTLEHPMHLSENSLNVLQLISGKKKIDLIYLKFLQCSCLPC
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12693553"
FT /id="VSP_022288"
FT VAR_SEQ 2150
FT /note="Q -> LCRGPCLYSFCASVSSISLSTVSKSGTSFSLYVYPVLQPPVHPPLLI
FT TSPVPQSALVAQLLLRLHCHLKTRHVDSLAFKKKTHAPSSPKCIFELFQFFKTKTQNVF
FT MILQNIKEKHRPGVEEERNRKWLFYKGNL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022227"
FT VAR_SEQ 2150
FT /note="Q -> QITGRDDPAKCGVERPYTTRVTSKGTAAVPVVSISSSAEV (in
FT isoform 4)"
FT /id="VSP_058822"
FT CONFLICT 1886..1887
FT /note="Missing (in Ref. 1; ADK73961)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2150 AA; 245758 MW; D7CDA1FE6476AB0E CRC64;
MAGERTRRFT RSLLRPGQAA ELRHSAASAA AVAVSSRQQQ RQEKPRLLDP LDYETVIEEL
EKTYRDDPLQ DLLFFPSDDF STATVSWDIR TLYSTVPEEA EHRAESLLVK EACKFYSSQW
YVVNYKYEQY SGDIRQLPRA EHKPEKLPSH SFEVDHEDAD KDEDTTSHSS SKGGGGAGGT
GVFKSGWLYK GNFNSTVNNT VTVRSFKKRY FQLTQLPDNS YIMNFYKDEK ISKEPKGCIF
LDSCTGVVQN NRLRKYAFEL KMNDLTYFVL AAETESDMDE WIHTLNRILQ ISPEGPLQGR
KSAELAELGL DPLDNCVTCE CTLEETDSSE NSLHPDFAKY LTETEDTVKT TRNMGRLNLF
SLDPDIDTLK LQKRDSFENE LMIKPFEEKA AKRIMIICRA LNFNLQGCVT ENEYDPVTNI
EPFFVSVALY DLRDNRKISA DFHVDLNHPA VRQMLSGTPP ALENGNIDTG TPRQSEEPHI
KGLPEEWLKF PKQAVFSVSD PHSEIVLVAK VEKVLMGNIG SGAEPYIKNP DSNKFAQKIL
KSNRQFCSKL GKYRMPFAWA VRSVFKDNQG NVDRDSRFSP LYRQESSKMS SEDLLKLVSD
YRRADRISKM QSIPGSLDIA VDNIPLEHPN CVTSSFIPVK PFNVSAQSEP TVEVEEFIYD
STKYCRPYRV YKNQIYVYPK HLKYDSQKCF NKARNITVCI EFKNSDDDGA KPMKCIYGKP
GGPLFTSSAY TAVLHHSQNP DFSDEVKIEL PTQLHGKHHL LFSFYHITCD INAKANAKKK
EALETSVGYA WLPLMKHDQI ASQEYNIPIA TTLPPNYLSI QDPTSAKHGG SDIKWVDGGK
PLFKVSTFVV STVNTQDPHV NAFFRQCQKR EKDMSQSPTS SFVRACKNLL NVDKIHSIMS
FLPIILNQLF KILVQNEEDE ITATVTRVLA DIVAKCHEEQ LDHSVQSYIK FVFKTKSYKE
RTIHEELAKN LSDLLKSNDS TIVKHVLEHS WFFFAIILKS MAQHLIDTNK IQLPRAQRFP
ESYQSELDNL VMGLCDHVIW KCKEAPEETK RANHSVARFL KRCFTFMDRG FVFKMVNNYI
SMFSSGEFKT LCQYKFDFLQ EVCQHEHFIP LCLPIRSANI PDPLTPSESI RELHASDMPE
YSVTNEFCRK HFLIGILLRE VGFALQEDQD IRHLALAVLK NLMAKHSFDD RYREPRKQAQ
IASLYMPLYG MLLDNMPRIY LKDLYPFTVN TSNQGSRDDL STNGGFQTQT SMKHATSVDT
SFSKDVLNSI AAFSSIAIST VNHADSRASL ASLDSNPSTT EKSSEKTDNC EKIPRPLSLI
GSTLRFDKLD QAETRSLLMC FLHIMKTISD ETLIAYWQRA PSPEVSDFFS ILDVCLQNFR
YLGKRNIIRK IAAAFKFVQS TQNNGTLKGS NPSCQTSGLL SQWMHTTSGH EGHKQHRSQT
LPIIRGKNAL SNPKLLQMLD NSMNSNSNEI DIVHHVDTEA NIATEVCLTI LDLLSLFTQV
HQRQLQQSDC QNSLMKRVFD TYMLFFQVNQ SASALKHVFA SLRLFVCKFP SAFFQGPADL
CGSFCYEVLK CCNHRSRLTQ MEASALLYFF MRKNFEFNKQ KSIVRSHLQL IKAVSQLIAD
AGIGGSRFQH SLAITNNFAN GDKQMKNSNF PAEVKDLTKR IRTVLMATAQ MKEHEKDPEM
LVDLQYSLAN SYASTPELRR TWLESMAKIH ARNGDLSEAA MCYIHIAALI AEYLKRKGYW
KMEKICTPPL LPEDTQPCDS NLLLTTPGGG SMFSMGWPAF LSITPNIKEE GAMKEDSGMQ
DTPYNENILV EQLYMCVEFL WKSERYELIA DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY
LKVAEVVNSE KRLFGRYYRV AFYGQAVGFF EEEEGKEYIY KEPKLTGLSE ISQRLLKLYA
DKFGADNVKI IQDSNKVNPK DLDPKYAYIQ VTYVTPFFEE KEIEDRKTDF EMHHNINRFV
FETPFTLSGK KHGGVAEQCK RRTVLTTSHL FPYVKKRIQV ISQSSTELNP IEVAIDEMSR
KVSELNQLCT TEEVDMIRLQ LKLQGSVSVK VNAGPMAYAR AFLEETNAKK YPDNQVKLLK
EIFRQFADAC GQALDVNERL IKEDQLEYQE ELRSHYKDML SELSAIMNEQ
