DOCK6_MOUSE
ID DOCK6_MOUSE Reviewed; 2080 AA.
AC Q8VDR9; E9QKQ0; Q3UM59; Q6PFY0; Q8BJS1; Q9D461;
DT 03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 4.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Dedicator of cytokinesis protein 6;
GN Name=Dock6; Synonyms=Kiaa1395;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1871-2080 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Aorta, Mammary gland, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 746-2080 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INDUCTION.
RX PubMed=17196961; DOI=10.1016/j.yexcr.2006.11.017;
RA Miyamoto Y., Yamauchi J., Sanbe A., Tanoue A.;
RT "Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual
RT specificity for Rac1 and Cdc42 and regulates neurite outgrowth.";
RL Exp. Cell Res. 313:791-804(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-870; SER-878;
RP SER-882; THR-2064 AND SER-2065, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [7]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=21820096; DOI=10.1016/j.ajhg.2011.07.009;
RA Shaheen R., Faqeih E., Sunker A., Morsy H., Al-Sheddi T., Shamseldin H.E.,
RA Adly N., Hashem M., Alkuraya F.S.;
RT "Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange
RT factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-
RT Oliver syndrome.";
RL Am. J. Hum. Genet. 89:328-333(2011).
RN [8]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-863, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for CDC42
CC and RAC1 small GTPases (By similarity). Through its activation of CDC42
CC and RAC1, regulates neurite outgrowth in an vitro differentiation
CC system. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear
CC region {ECO:0000250}. Note=Mainly located near the cell surface.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8VDR9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8VDR9-2; Sequence=VSP_022259, VSP_022260, VSP_022261;
CC Name=3;
CC IsoId=Q8VDR9-3; Sequence=VSP_022257, VSP_022258;
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in lung and
CC heart. {ECO:0000269|PubMed:21820096}.
CC -!- DEVELOPMENTAL STAGE: Expressed at 9.5 dpc in the growing edge of the
CC limb buds and in the developing heart. At 10.5 dpc, strongly expressed
CC at the edge of the limb buds, while expression in the heart maintained.
CC At 11.5 dpc, detected in the apical ectodermal ridge of all 4 limbs,
CC with higher expression in hindlimbs than in forelimbs. By 12.5 and 13.5
CC dpc, expression pattern more diffused in the limbs. At 13.5 dpc,
CC clearly observed in the developing digits.
CC {ECO:0000269|PubMed:21820096}.
CC -!- INDUCTION: Up-regulated during differentiation of the N1E-115
CC neuroblastoma cell line. {ECO:0000269|PubMed:17196961}.
CC -!- DOMAIN: The DOCKER domain may mediate some GEF activity. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000255|PROSITE-
CC ProRule:PRU00983}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21414.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH21414.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Vector contamination at the N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC37843.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK016777; BAB30423.2; -; mRNA.
DR EMBL; AK080190; BAC37843.1; ALT_FRAME; mRNA.
DR EMBL; AK145109; BAE26239.1; -; mRNA.
DR EMBL; AC161371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC166992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC021414; AAH21414.1; ALT_INIT; mRNA.
DR EMBL; BC043042; AAH43042.1; -; mRNA.
DR EMBL; BC057368; AAH57368.2; -; mRNA.
DR RefSeq; NP_796004.2; NM_177030.3.
DR RefSeq; XP_011240856.1; XM_011242554.2. [Q8VDR9-1]
DR AlphaFoldDB; Q8VDR9; -.
DR SMR; Q8VDR9; -.
DR BioGRID; 235607; 3.
DR STRING; 10090.ENSMUSP00000034728; -.
DR iPTMnet; Q8VDR9; -.
DR PhosphoSitePlus; Q8VDR9; -.
DR jPOST; Q8VDR9; -.
DR MaxQB; Q8VDR9; -.
DR PaxDb; Q8VDR9; -.
DR PeptideAtlas; Q8VDR9; -.
DR PRIDE; Q8VDR9; -.
DR ProteomicsDB; 279755; -. [Q8VDR9-1]
DR ProteomicsDB; 279756; -. [Q8VDR9-2]
DR ProteomicsDB; 279757; -. [Q8VDR9-3]
DR Antibodypedia; 69705; 43 antibodies from 13 providers.
DR Ensembl; ENSMUST00000034728; ENSMUSP00000034728; ENSMUSG00000032198. [Q8VDR9-1]
DR GeneID; 319899; -.
DR KEGG; mmu:319899; -.
DR UCSC; uc009omn.1; mouse. [Q8VDR9-1]
DR UCSC; uc009omq.1; mouse. [Q8VDR9-2]
DR UCSC; uc009omt.1; mouse. [Q8VDR9-3]
DR CTD; 57572; -.
DR MGI; MGI:1914789; Dock6.
DR VEuPathDB; HostDB:ENSMUSG00000032198; -.
DR eggNOG; KOG1997; Eukaryota.
DR GeneTree; ENSGT00940000159313; -.
DR InParanoid; Q8VDR9; -.
DR OrthoDB; 20156at2759; -.
DR Reactome; R-MMU-9013148; CDC42 GTPase cycle.
DR Reactome; R-MMU-9013149; RAC1 GTPase cycle.
DR Reactome; R-MMU-983231; Factors involved in megakaryocyte development and platelet production.
DR BioGRID-ORCS; 319899; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Dock6; mouse.
DR PRO; PR:Q8VDR9; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8VDR9; protein.
DR Bgee; ENSMUSG00000032198; Expressed in dorsal pancreas and 205 other tissues.
DR ExpressionAtlas; Q8VDR9; baseline and differential.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR PANTHER; PTHR23317; PTHR23317; 1.
DR Pfam; PF06920; DHR-2; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DUF3398; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Guanine-nucleotide releasing factor;
KW Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..2080
FT /note="Dedicator of cytokinesis protein 6"
FT /id="PRO_0000189994"
FT DOMAIN 546..712
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00983"
FT DOMAIN 1620..2056
FT /note="DOCKER"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00984"
FT REGION 20..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 178
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 863
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 870
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 878
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 882
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1341
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96HP0"
FT MOD_RES 2064
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2065
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2069
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96HP0"
FT VAR_SEQ 241..244
FT /note="DEAV -> VGAY (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022257"
FT VAR_SEQ 245..2080
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022258"
FT VAR_SEQ 905..939
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022259"
FT VAR_SEQ 1019..1062
FT /note="DMKLAERLNASLAFFLSDLLSIADRGYIFSLVRAHYKQVATRLQ -> VRKD
FT SAQGCSVVRDPVCHVGLFIHGLFLEHLWFTWPWLDVETQL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022260"
FT VAR_SEQ 1063..2080
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022261"
FT CONFLICT 145
FT /note="W -> R (in Ref. 1; BAE26239)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2080 AA; 233267 MW; AC9541FB05DB78D0 CRC64;
MAASERRAFA HKINRTVAAE VRKQVSRERS GSPHSSRRSS SSLGVPLTEV IEPLDFEDVL
LSRPPEVEPG PLRDLIEFPV DDLELLKQPR ECRTTESGVP EDGQLDAQVR AAVEMYSEDW
VIVRRRYQHL STAYSPITTE TQREWQKGLT CQVFEQDTPG DERTGPEDVD DPQHCSGSPE
DTPRSSGASG IFSLRNLAAD SLLPTLLEQA APEDVDRRNE ALRRQHRAPT LLTLYPAPDE
DEAVERCSRP EPPREHFGQR ILVKCLSLKF EIEIEPIFGT LALYDVREKK KISENFYFDL
NSDSVKGLLR AHGTHPAIST LARSAIFSVT YPSPDIFLVV KLEKVLQQGD ISECCEPYMV
MKEADTAKNK EKLEKLRLAA EQFCTRLGRY RMPFAWTAVH LANIVSRPQD RDSDSEGERR
PTWAERRRRG PQDRGYSGDD ACSFSSFRPA TLTVTNFFKQ EAERLSDEDL FKFLADMRRP
SSLLRRLRPV TAQLKLDISP APENLHFCLS PDLLHVKPYP DPRGRPTKEI LEFPAREVYA
PHSCYRNLLF VYPHSLNFSS RQGSVRNLAV RIQYMAGEDQ SQALPVIFGK SSCSEFTREA
FTPVVYHNKS PEFYEEFKLR LPACVTENHH LFFTFYHVSC QPRPGTALET PVGFTWIPLL
QHGRLRTGPF CLPVSVDQPP PSYSVLTPDV ALPGMRWVDG HKGVFSVELT AVSSVHPQDP
HLDKFFTLVH VLEEGIFPFR LKETVLSEGT MEQELRASLA ALRLASPEPL VAFSHLVLDK
LVRLVVRPPI ICGQMVNLGR GAFEAMAHVA SLVHRNLEAV QDSRGHCPLL ASYVHYAFRL
PGGDLSLPGE APPATVQAAT LARGSGRPAS LYLARSKSIS SSNPDLAVVP GSVDDEVSRI
LASKGVDRSH SWVNSAYAPG GSKAVLRRVP PYCGADPRQL LHEELALQWV VSGSAVRELV
LQHAWFFFQL MVKSMELHLL LGQRLDTPRK LRFPGRFLDD IAALVASVGL EVITRVHKDM
KLAERLNASL AFFLSDLLSI ADRGYIFSLV RAHYKQVATR LQSAPNPTAL LTLRMDFTRI
LCSHEHYVTL NLPCCPLSPP ASPSPSVSST TSQSSTFSSQ APDPKVTSMF ELSGPFRQQH
FLSGLLLTEL ALALDPEAEG ASLLHKKAIS AVHSLLCSHD VDSRYAEATV KAKVAELYLP
LLSLARDTLP QLHGFAEGSG QRSRLASMLD SDTEGEGDIG STINPSVAMA IAGGPLAPGS
RTSISQGPST AARSGCPLSA ESSRTLLVCV LWVLKNAEPT LLQRWAADLA LPQLGRLLDL
LYLCLAAFEY KGKKAFERIN SLTFKKSLDM KARLEEAILG TIGARQEMVR RSRERSPFGN
QENVRWRKSA THWRQTSDRV DKTKDEMEHE ALVDGNLATE ASLVVLDTLE TIVQTVMLSE
ARESILSAVL KVVLYSLGSA QSALFLQHGL ATQRALVSKF PELLFEEDTE LCADLCLRLL
RHCGSRISTI RMHASASLYL LMRQNFEIGH NFARVKMLVT MSLSSLVGTT QNFSEEHLRK
SLKTILTYAE EDIGLRDSTF AEQVQDLMFN LHMILTDTVK MKEHQEDPEM LMDLMYRIAR
GYQGSPDLRL TWLQNMAGKH AELGNHAEAA QCMVHAAALV AEYLALLEDS RHLPVGCVSF
QNVSSNVLEE SAISDDILSP DEEGFCSGKN FTELGLVGLL EQAAGYFTMG GLYEAVNEVY
KNLIPILEAH RDYKKLAAVH GKLQEAFTKI MHQSSGWERV FGTYFRVGFY GTRFGDLDEQ
EFVYKEPSIT KLAEISHRLE EFYTERFGDD VVEIIKDSNP VDKSKLDPQK AYIQITYVEP
HFDTYELKDR VTYFDRNYGL RAFLFCTPFT PDGRAHGELA EQHKRKTLLS TEHAFPYIKT
RIRVCHREET VLTPVEVAIE DMQKKTRELA FATEQDPPDA KMLQMVLQGS VGPTVNQGPL
EVAQVFLSEI PEDPKLFRHH NKLRLCFKDF CKKCEDALRK NKALIGPDQK EYHRELERHY
SRLREALQPL LTQRLPQLLA PSSTSLRSSM NRSSFRKADL
