ID   DOCK9_RAT               Reviewed;         720 AA.
AC   Q63603;
DT   03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   03-JUL-2003, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Dedicator of cytokinesis protein 9;
DE   AltName: Full=Cdc42 guanine nucleotide exchange factor zizimin-1;
DE   AltName: Full=Protein TRG;
DE   Flags: Fragment;
GN   Name=Dock9; Synonyms=Trg;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Fischer;
RA   Pianese L., Porcellini A., Avvedimento V.E., D'Esposti F., Feliciello A.,
RA   Monticelli A., Musti A.M., Tortora G., Varrone S., Cocozza S.;
RT   "A novel thyroid transcript negatively regulated by tsh.";
RL   Life Sci. Adv. (Mol. Biol.) 13:75-83(1994).
CC   -!- FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42
CC       by exchanging bound GDP for free GTP. Overexpression induces filopodia
CC       formation (By similarity). {ECO:0000250|UniProtKB:Q8BIK4,
CC       ECO:0000250|UniProtKB:Q9BZ29}.
CC   -!- SUBUNIT: Homodimer. Interacts preferentially with nucleotide-depleted
CC       CDC42 (By similarity). {ECO:0000250|UniProtKB:Q9BZ29}.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305}.
CC       Note=Associated with membranes. {ECO:0000305}.
CC   -!- DOMAIN: The DOCKER domain is necessary and sufficient for the GEF
CC       activity. {ECO:0000250|UniProtKB:Q8BIK4}.
CC   -!- MISCELLANEOUS: 'Zizim' means 'spike' in Hebrew.
CC   -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA48220.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X68101; CAA48220.1; ALT_FRAME; mRNA.
DR   PIR; I60486; I60486.
DR   AlphaFoldDB; Q63603; -.
DR   SMR; Q63603; -.
DR   IntAct; Q63603; 1.
DR   PRIDE; Q63603; -.
DR   RGD; 629617; Dock9.
DR   InParanoid; Q63603; -.
DR   PhylomeDB; Q63603; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0031267; F:small GTPase binding; ISO:RGD.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.20.58.740; -; 1.
DR   Gene3D; 1.25.40.410; -; 1.
DR   InterPro; IPR026791; DOCK.
DR   InterPro; IPR026796; DOCK9.
DR   InterPro; IPR043161; DOCK_C_lobe_A.
DR   InterPro; IPR043162; DOCK_C_lobe_C.
DR   InterPro; IPR027357; DOCKER_dom.
DR   PANTHER; PTHR23317; PTHR23317; 1.
DR   PANTHER; PTHR23317:SF77; PTHR23317:SF77; 1.
DR   Pfam; PF06920; DHR-2; 1.
DR   PROSITE; PS51651; DOCKER; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Membrane; Reference proteome.
FT   CHAIN           <1..720
FT                   /note="Dedicator of cytokinesis protein 9"
FT                   /id="PRO_0000190001"
FT   DOMAIN          186..638
FT                   /note="DOCKER"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00984"
FT   REGION          277..638
FT                   /note="Interaction with CDC42"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BZ29"
FT   NON_TER         1
SQ   SEQUENCE   720 AA;  82455 MW;  650A4F4BD3DF816C CRC64;
     KLSRGHSPLM KKVFDVYLCF LQKHQSEMAL KNVFTALRSL IYKFPSTFYE GRADMCASLC
     YEVLKCCNSK LSSIRTEASQ LLYFLMRNNF DYTGKKSFVR THLQVIISLS QLIADVVGIG
     GTRFQQSLSI INNCANSDRL IKHTSFSSDV KDLTKRIRTV LMATAQMKEH ENDPEMLVDL
     QYSLAKSYAS TPELRKTWLD SMARIHVKNG DLSEAAMCYV HVTALVAEYL TRKEADLALQ
     REPPVFPYSH TSCQRKSRGG MFRQGCTAFR VITPNIDEEA SMMEDVGMQD VHFNEDVLME
     LLEQCADGLW KAERLRAGLL TSINSSSPSM KSGGTLETTH LYDTLHRPYS KVTEVITRAA
     GSWDLLPGGL FGQGFFEDED GKEYIYKEPK LTPLSEISQR LLKLYSDKFG SENVKMIQDS
     GKVNPKDLDS KFAYIQVTHV TPFFDEKELQ ERKTEFERCH NIRRFMFEMP FTQTGKRQGG
     VEEQCKRRTI LTAIHCFPYV KKRIPVMYQH HTDLNPIEVA IDEMSKKVAE LHQLCSSAEV
     DMIKLQLKLQ GSVSVQVNAG PLAYARAFLD DTNTKRYPDN KVKLLKEVFR QFVEACGQAL
     AVNERLIKED QLEYQEEMKA NYREIRKELS DIIVPRICPG EDKRATKFPA HLQRHQRDTN
     KHSGSRVDQF ILSCVTLPHE PHVGTCFVMC KLRTTFRANH WFCQAQEEAM GNGREKEPGL