DOD_DROME
ID DOD_DROME Reviewed; 166 AA.
AC P54353; C6TP71; O61344; Q9VRH1;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Putative peptidyl-prolyl cis-trans isomerase dodo;
DE Short=PPIase dodo;
DE EC=5.2.1.8;
DE AltName: Full=Rotamase dodo;
GN Name=dod; ORFNames=CG17051;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Oregon-R; TISSUE=Larva, and Pupae;
RX PubMed=8552658; DOI=10.1073/pnas.93.1.447;
RA Maleszka R., Hanes S.D., Hackett R.L., de Couet H.G., Miklos G.L.G.;
RT "The Drosophila melanogaster dodo (dod) gene, conserved in humans, is
RT functionally interchangeable with the ESS1 cell division gene of
RT Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:447-451(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Canton-S;
RX PubMed=9520435; DOI=10.1073/pnas.95.7.3731;
RA Maleszka R., de Couet H.G., Miklos G.L.G.;
RT "Data transferability from model organisms to human beings: insights from
RT the functional genomics of the flightless region of Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:3731-3736(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
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DR EMBL; U35140; AAC46958.1; -; mRNA.
DR EMBL; AF017777; AAC28408.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF50829.1; -; Genomic_DNA.
DR EMBL; BT099557; ACU32641.1; -; mRNA.
DR PIR; T08426; T08426.
DR RefSeq; NP_523428.1; NM_078704.4.
DR AlphaFoldDB; P54353; -.
DR SMR; P54353; -.
DR BioGRID; 59389; 44.
DR DIP; DIP-18540N; -.
DR IntAct; P54353; 6.
DR STRING; 7227.FBpp0076894; -.
DR PaxDb; P54353; -.
DR PRIDE; P54353; -.
DR DNASU; 33111; -.
DR EnsemblMetazoa; FBtr0077193; FBpp0076894; FBgn0015379.
DR GeneID; 33111; -.
DR KEGG; dme:Dmel_CG17051; -.
DR UCSC; CG17051-RA; d. melanogaster.
DR CTD; 33111; -.
DR FlyBase; FBgn0015379; dod.
DR VEuPathDB; VectorBase:FBgn0015379; -.
DR eggNOG; KOG3259; Eukaryota.
DR GeneTree; ENSGT00640000091578; -.
DR HOGENOM; CLU_090028_0_1_1; -.
DR InParanoid; P54353; -.
DR OMA; DEVQCLH; -.
DR OrthoDB; 1437969at2759; -.
DR PhylomeDB; P54353; -.
DR BRENDA; 5.2.1.8; 1994.
DR Reactome; R-DME-6804756; Regulation of TP53 Activity through Phosphorylation.
DR Reactome; R-DME-6811555; PI5P Regulates TP53 Acetylation.
DR BioGRID-ORCS; 33111; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33111; -.
DR PRO; PR:P54353; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0015379; Expressed in antenna and 19 other tissues.
DR Genevisible; P54353; DM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; ISS:FlyBase.
DR GO; GO:0008134; F:transcription factor binding; IPI:FlyBase.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IDA:FlyBase.
DR GO; GO:1904059; P:regulation of locomotor rhythm; IMP:FlyBase.
DR CDD; cd00201; WW; 1.
DR Gene3D; 3.10.50.40; -; 1.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR000297; PPIase_PpiC.
DR InterPro; IPR023058; PPIase_PpiC_CS.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR Pfam; PF00639; Rotamase; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF51045; SSF51045; 1.
DR PROSITE; PS01096; PPIC_PPIASE_1; 1.
DR PROSITE; PS50198; PPIC_PPIASE_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 2: Evidence at transcript level;
KW Isomerase; Reference proteome; Rotamase.
FT CHAIN 1..166
FT /note="Putative peptidyl-prolyl cis-trans isomerase dodo"
FT /id="PRO_0000193432"
FT DOMAIN 5..39
FT /note="WW"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 55..166
FT /note="PpiC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00278"
FT REGION 32..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 44
FT /note="A -> T (in Ref. 2; AAC28408)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 166 AA; 18377 MW; 3B4306FA930E7259 CRC64;
MPDAEQLPDG WEKRTSRSTG MSYYLNMYTK ESQWDQPTEP AKKAGGGSAG GGDAPDEVHC
LHLLVKHKGS RRPSSWREAN ITRTKEEAQL LLEVYRNKIV QQEATFDELA RSYSDCSSAK
RGGDLGKFGR GQMQAAFEDA AFKLNVNQLS GIVDSDSGLH IILRKA
