ID   DOEX_HALED              Reviewed;         158 AA.
AC   E1V7V9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Transcriptional regulatory protein DoeX;
GN   Name=doeX; OrderedLocusNames=HELO_3663;
OS   Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198
OS   / 1H9).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=768066;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9;
RX   PubMed=20849449; DOI=10.1111/j.1462-2920.2010.02336.x;
RA   Schwibbert K., Marin-Sanguino A., Bagyan I., Heidrich G., Lentzen G.,
RA   Seitz H., Rampp M., Schuster S.C., Klenk H.P., Pfeiffer F., Oesterhelt D.,
RA   Kunte H.J.;
RT   "A blueprint of ectoine metabolism from the genome of the industrial
RT   producer Halomonas elongata DSM 2581(T).";
RL   Environ. Microbiol. 13:1973-1994(2011).
CC   -!- FUNCTION: Acts as a transcriptional regulator. It binds DNA
CC       specifically to a fragment from the doeA promoter region.
CC       {ECO:0000269|PubMed:20849449}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; FN869568; CBV43547.1; -; Genomic_DNA.
DR   AlphaFoldDB; E1V7V9; -.
DR   SMR; E1V7V9; -.
DR   STRING; 768066.HELO_3663; -.
DR   EnsemblBacteria; CBV43547; CBV43547; HELO_3663.
DR   KEGG; hel:HELO_3663; -.
DR   eggNOG; COG1522; Bacteria.
DR   HOGENOM; CLU_091233_0_0_6; -.
DR   OMA; YRAQIDW; -.
DR   Proteomes; UP000008707; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54909; SSF54909; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..158
FT                   /note="Transcriptional regulatory protein DoeX"
FT                   /id="PRO_0000428761"
FT   DOMAIN          3..64
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
SQ   SEQUENCE   158 AA;  17891 MW;  B91A71572B9E7DF1 CRC64;
     MKLDRYDLKI LEILSRDGRI TKSKLAEAIN LSVSPCWERV RRLEKAGVIE GYGARLNTDV
     LVKRTPVWVQ IELKAHNAES FARFEALVHD TPEVTECVAV GGGVDYLVKF EATTIDTYQR
     LIDEWLVSDV GIERYFTYIV TKTVKRPSAS ISIDDLAT