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DOF51_ARATH
ID   DOF51_ARATH             Reviewed;         399 AA.
AC   Q9LZ56; C0SVM8;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Dof zinc finger protein DOF5.1 {ECO:0000303|PubMed:12475498};
DE            Short=AtDOF5.1 {ECO:0000303|PubMed:12475498};
DE   AltName: Full=Protein PHLOEM EARLY DOF 2 {ECO:0000303|PubMed:30626969};
GN   Name=DOF5.1 {ECO:0000303|PubMed:12475498};
GN   Synonyms=PEAR2 {ECO:0000303|PubMed:30626969};
GN   OrderedLocusNames=At5g02460 {ECO:0000312|Araport:AT5G02460};
GN   ORFNames=T1E22.3 {ECO:0000312|EMBL:AL162874},
GN   T22P11_50 {ECO:0000312|EMBL:CAB85983.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Fujita M.;
RT   "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14993207; DOI=10.1101/gr.1515604;
RA   Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA   Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA   Weissenbach J., Salanoubat M.;
RT   "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT   combined approach to evaluate and improve Arabidopsis genome annotation.";
RL   Genome Res. 14:406-413(2004).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12475498; DOI=10.1016/s1360-1385(02)02362-2;
RA   Yanagisawa S.;
RT   "The Dof family of plant transcription factors.";
RL   Trends Plant Sci. 7:555-560(2002).
RN   [6]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=cv. Columbia;
RX   PubMed=17583520; DOI=10.1016/j.plaphy.2007.05.001;
RA   Konishi M., Yanagisawa S.;
RT   "Sequential activation of two Dof transcription factor gene promoters
RT   during vascular development in Arabidopsis thaliana.";
RL   Plant Physiol. Biochem. 45:623-629(2007).
RN   [7]
RP   FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=cv. C24, and cv. Columbia;
RX   PubMed=20807212; DOI=10.1111/j.1365-313x.2010.04346.x;
RA   Kim H.-S., Kim S.J., Abbasi N., Bressan R.A., Yun D.-J., Yoo S.-D.,
RA   Kwon S.-Y., Choi S.-B.;
RT   "The DOF transcription factor Dof5.1 influences leaf axial patterning by
RT   promoting Revoluta transcription in Arabidopsis.";
RL   Plant J. 64:524-535(2010).
RN   [8]
RP   FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND INDUCTION BY
RP   CYTOKININ.
RX   PubMed=30626969; DOI=10.1038/s41586-018-0839-y;
RA   Miyashima S., Roszak P., Sevilem I., Toyokura K., Blob B., Heo J.-O.,
RA   Mellor N., Help-Rinta-Rahko H., Otero S., Smet W., Boekschoten M.,
RA   Hooiveld G., Hashimoto K., Smetana O., Siligato R., Wallner E.-S.,
RA   Maehoenen A.P., Kondo Y., Melnyk C.W., Greb T., Nakajima K., Sozzani R.,
RA   Bishopp A., De Rybel B., Helariutta Y.;
RT   "Mobile PEAR transcription factors integrate positional cues to prime
RT   cambial growth.";
RL   Nature 565:490-494(2019).
CC   -!- FUNCTION: Transcription factor that binds specifically to a 5'-AA[AG]G-
CC       3' consensus core sequence (By similarity). Binds to 5'-TAAAGT-3' motif
CC       in REV promoter to triggers its transcription, thus regulating adaxial-
CC       abaxial polarity and influencing leaf axial patterning in an auxin
CC       transport- and response-dependent manner (e.g. IAA6 and IAA19 genes
CC       expression) (PubMed:20807212). Probably involved in early processes for
CC       vascular development (PubMed:17583520). The PEAR proteins (e.g. DOF2.4,
CC       DOF5.1, DOF3.2, DOF1.1, DOF5.6 and DOF5.3) activate gene expression
CC       that promotes radial growth of protophloem sieve elements
CC       (PubMed:30626969). {ECO:0000250|UniProtKB:Q9M2U1,
CC       ECO:0000269|PubMed:17583520, ECO:0000269|PubMed:20807212,
CC       ECO:0000269|PubMed:30626969}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00071,
CC       ECO:0000269|PubMed:20807212}.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously, especially in the vascular
CC       tissues, except in seeds, petals and anthers (PubMed:20807212).
CC       Specific to the vascular tissues in young leaves, cotyledons and flower
CC       buds (PubMed:17583520). The PEAR proteins (e.g. DOF2.4, DOF5.1, DOF3.2,
CC       DOF1.1, DOF5.6 and DOF5.3) form a short-range concentration gradient
CC       that peaks at protophloem sieve elements (PSE) (PubMed:30626969).
CC       {ECO:0000269|PubMed:17583520, ECO:0000269|PubMed:20807212,
CC       ECO:0000269|PubMed:30626969}.
CC   -!- DEVELOPMENTAL STAGE: Specific to both elongating procambial cells and
CC       to cells isodiametric in size that are presumably destined to develop
CC       into higher-order veins. Strongly expressed in advance of perceptible
CC       procambium formation. Expressed in the cells of prospective veins in
CC       leaf primordia of seedlings and cotyledons of developing embryos, and
CC       the vascular tissue of developing flower buds.
CC       {ECO:0000269|PubMed:17583520}.
CC   -!- INDUCTION: By cytokinin in procambium. {ECO:0000269|PubMed:30626969}.
CC   -!- DISRUPTION PHENOTYPE: Narrow and down-wardly curled leaves
CC       (PubMed:20807212). The pear1 pear2 tmo6 triple mutant variably displays
CC       reduced radial growth. The pear1 pear2 dof6 tmo6 quadruple mutant
CC       plants showed a greater uniform reduction in radial growth, associated
CC       with compromised symplastic trafficking (PubMed:30626969).
CC       {ECO:0000269|PubMed:20807212, ECO:0000269|PubMed:30626969}.
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DR   EMBL; AB493731; BAH30569.1; -; mRNA.
DR   EMBL; AL162874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL162971; CAB85983.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED90474.1; -; Genomic_DNA.
DR   EMBL; BX829408; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; T48267; T48267.
DR   RefSeq; NP_195866.1; NM_120324.4.
DR   AlphaFoldDB; Q9LZ56; -.
DR   STRING; 3702.AT5G02460.1; -.
DR   PaxDb; Q9LZ56; -.
DR   PRIDE; Q9LZ56; -.
DR   ProteomicsDB; 222124; -.
DR   EnsemblPlants; AT5G02460.1; AT5G02460.1; AT5G02460.
DR   GeneID; 830976; -.
DR   Gramene; AT5G02460.1; AT5G02460.1; AT5G02460.
DR   KEGG; ath:AT5G02460; -.
DR   Araport; AT5G02460; -.
DR   TAIR; locus:2181773; AT5G02460.
DR   eggNOG; ENOG502QTHW; Eukaryota.
DR   HOGENOM; CLU_036438_0_3_1; -.
DR   InParanoid; Q9LZ56; -.
DR   OMA; RMANIPL; -.
DR   OrthoDB; 1130450at2759; -.
DR   PhylomeDB; Q9LZ56; -.
DR   PRO; PR:Q9LZ56; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9LZ56; baseline and differential.
DR   Genevisible; Q9LZ56; AT.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0010497; P:plasmodesmata-mediated intercellular transport; IDA:TAIR.
DR   GO; GO:0009944; P:polarity specification of adaxial/abaxial axis; IMP:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   GO; GO:0090057; P:root radial pattern formation; IGI:TAIR.
DR   InterPro; IPR045174; Dof.
DR   InterPro; IPR003851; Znf_Dof.
DR   PANTHER; PTHR31992; PTHR31992; 1.
DR   Pfam; PF02701; zf-Dof; 1.
DR   PROSITE; PS01361; ZF_DOF_1; 1.
DR   PROSITE; PS50884; ZF_DOF_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..399
FT                   /note="Dof zinc finger protein DOF5.1"
FT                   /id="PRO_0000074291"
FT   ZN_FING         95..149
FT                   /note="Dof-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00071"
FT   REGION          139..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..176
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         97
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00071"
FT   BINDING         100
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00071"
FT   BINDING         122
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00071"
FT   BINDING         125
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00071"
SQ   SEQUENCE   399 AA;  42531 MW;  082974FD5F91C297 CRC64;
     MVFSSFPTYP DHSSNWQQQH QPITTTVGFT GNNINQQFLP HHPLPPQQQQ TPPQLHHNNG
     NGGVAVPGGP GGLIRPGSMA ERARLANIPL PETALKCPRC DSTNTKFCYF NNYSLTQPRH
     FCKACRRYWT RGGALRSVPV GGGCRRNKRT KNSSGGGGGS TSSGNSKSQD SATSNDQYHH
     RAMANNQMGP PSSSSSLSSL LSSYNAGLIP GHDHNSNNNN ILGLGSSLPP LKLMPPLDFT
     DNFTLQYGAV SAPSYHIGGG SSGGAAALLN GFDQWRFPAT NQLPLGGLDP FDQQHQMEQQ
     NPGYGLVTGS GQYRPKNIFH NLISSSSSAS SAMVTATASQ LASVKMEDSN NQLNLSRQLF
     GDEQQLWNIH GAAAASTAAA TSSWSEVSNN FSSSSTSNI
 
 
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