ID   DOK4_PONAB              Reviewed;         339 AA.
AC   Q5RA30;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Docking protein 4;
DE   AltName: Full=Downstream of tyrosine kinase 4;
GN   Name=DOK4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding
CC       proteins. They provide a docking platform for the assembly of
CC       multimolecular signaling complexes. DOK4 functions in RET-mediated
CC       neurite outgrowth and plays a positive role in activation of the MAP
CC       kinase pathway (By similarity). Putative link with downstream effectors
CC       of RET in neuronal differentiation. May be involved in the regulation
CC       of the immune response induced by T-cells (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RET and TEK/TIE2. Interaction with RET is
CC       mediated through the PTB domain and requires phosphorylation of RET (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: PTB domain mediates receptor interaction. {ECO:0000250}.
CC   -!- PTM: Phosphorylated on tyrosine residues in response to insulin, IGF1
CC       or RET stimulation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DOK family. Type B subfamily. {ECO:0000305}.
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DR   EMBL; CR859193; CAH91380.1; -; mRNA.
DR   RefSeq; NP_001125815.1; NM_001132343.1.
DR   AlphaFoldDB; Q5RA30; -.
DR   SMR; Q5RA30; -.
DR   STRING; 9601.ENSPPYP00000008351; -.
DR   GeneID; 100172743; -.
DR   KEGG; pon:100172743; -.
DR   CTD; 55715; -.
DR   eggNOG; KOG4047; Eukaryota.
DR   InParanoid; Q5RA30; -.
DR   Proteomes; UP000001595; Unplaced.
DR   CDD; cd14678; PH_DOK4_DOK5_DOK6; 1.
DR   Gene3D; 2.30.29.30; -; 2.
DR   InterPro; IPR037816; DOK4/5/6_PH.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF02174; IRS; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00310; PTBI; 1.
DR   PROSITE; PS51064; IRS_PTB; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..339
FT                   /note="Docking protein 4"
FT                   /id="PRO_0000187276"
FT   DOMAIN          7..112
FT                   /note="PH"
FT   DOMAIN          132..237
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00389"
FT   MOTIF           265..275
FT                   /note="DKFBH motif"
SQ   SEQUENCE   339 AA;  38621 MW;  E465BD320AE17A80 CRC64;
     MATNFSDIVK QGYVKMKSRK LGIYRRCWLV FRKSSSKGPQ RLEKYPDEKS VCLRGCPKVT
     EISNVKCVTR LPKETKRQAV AIIFTDDSAR TFTCDSELEA EEWYKTLSVE CLGSRLNDIS
     LGEPDLLAPG VQCEQTDRFN VFLLPCPNLD VYGECKLQIT HENIYLWDIH NPRVKLVSWP
     LCSLRRYGRD AARFTFEAGR MCDAGEGLYT FQTQEGEQIY QRVHSATLAI AEQHKRVLLE
     MEKNVRLLNK GTEHYSYPCT PTTMLPRSAY WHHITGSQNI AEASSYAAQG PEQQVASQFL
     WAWSDTGRIC ASTVLLASLA VGVLSRGDIW LTPQVKIWF