ID   DONS_XENLA              Reviewed;         579 AA.
AC   Q5U4U4;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Protein downstream neighbor of son homolog;
GN   Name=donson {ECO:0000250|UniProtKB:Q6P1U0};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH84950.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH84950.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Replisome component that maintains genome stability by
CC       protecting stalled or damaged replication forks. After the induction of
CC       replication stress, required for the stabilization of stalled
CC       replication forks, the efficient activation of the intra-S-phase and
CC       G/2M cell-cycle checkpoints and the maintenance of genome stability.
CC       {ECO:0000250|UniProtKB:Q9NYP3}.
CC   -!- SUBUNIT: Component of the replisome complex.
CC       {ECO:0000250|UniProtKB:Q9NYP3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NYP3}.
CC       Note=Localizes at DNA replication sites.
CC       {ECO:0000250|UniProtKB:Q9NYP3}.
CC   -!- SIMILARITY: Belongs to the DONSON family. {ECO:0000255}.
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DR   EMBL; BC084950; AAH84950.1; -; mRNA.
DR   RefSeq; NP_001088556.1; NM_001095087.1.
DR   AlphaFoldDB; Q5U4U4; -.
DR   MaxQB; Q5U4U4; -.
DR   DNASU; 495432; -.
DR   GeneID; 495432; -.
DR   KEGG; xla:495432; -.
DR   CTD; 495432; -.
DR   Xenbase; XB-GENE-1007407; donson.L.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 495432; Expressed in egg cell and 17 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005657; C:replication fork; ISS:UniProtKB.
DR   GO; GO:0030894; C:replisome; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0006260; P:DNA replication; ISS:UniProtKB.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0048478; P:replication fork protection; ISS:UniProtKB.
DR   InterPro; IPR024861; Donson.
DR   PANTHER; PTHR12972; PTHR12972; 1.
DR   PRINTS; PR02064; DONSON.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Developmental protein; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..579
FT                   /note="Protein downstream neighbor of son homolog"
FT                   /id="PRO_0000236812"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..353
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  63785 MW;  5C13EF67B91A376A CRC64;
     MAELLPGYSP SFKKPSEILR LSRRRSRSEA SKTGLSPFSP GDVIKRVPGL RPFSPGPNKG
     AGVKRRNPFA SLENTVCSPV KRRAETVAEY GAASLEPRAL SAVRPSCLGQ DSPEPPQFNS
     VEDVIWGDPL AADADPLVKT ESPEKPAPAC EIPKGSVTFP ADWSLKTRLL FTSSHSFSWA
     DHLKAQEEAQ GLVMQCRATA VNLPHSIQEP KLSTDLRCAF QQSLVHWIHP SLPWVQLFPR
     IGVDRKMAGK NTPWSQDESL QQVLMSEWAL SFTSLYNLLK AKLCPYFYVC TYQFTVLFRA
     AGLAGSDVIT AVMSPTTRGL REAMKNEGIT FSQPLVEDDT GKKQKKPEAA SQGDINPEKE
     NGTAEADEAS DESDEDESFS WLEEMGVEDK IKKPDSISIK LRKEKNEVKL DHKPESVVLV
     KGTNTFTLLN FLINCKSIVA AAGLQAGLPP TLLSPVAFRG ATMHALKARS VNVKTRVNSG
     YKDQFSLEIT GPIMPHSLHS LTMLLQSAQR GSFSAGLYTH EPTAVFNTPI HSQAVKEISA
     DLQNCGLHPC TVEQLTQVNE LGKLSLRHLE MTDYRYTWK