ID   DONS_XENTR              Reviewed;         577 AA.
AC   Q6P1U0;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein downstream neighbor of son homolog;
GN   Name=donson {ECO:0000312|EMBL:AAH64871.1}; ORFNames=TEgg057j18.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH64871.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:AAH64871.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH64871.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Replisome component that maintains genome stability by
CC       protecting stalled or damaged replication forks. After the induction of
CC       replication stress, required for the stabilization of stalled
CC       replication forks, the efficient activation of the intra-S-phase and
CC       G/2M cell-cycle checkpoints and the maintenance of genome stability.
CC       {ECO:0000250|UniProtKB:Q9NYP3}.
CC   -!- SUBUNIT: Component of the replisome complex.
CC       {ECO:0000250|UniProtKB:Q9NYP3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NYP3}.
CC       Note=Localizes at DNA replication sites.
CC       {ECO:0000250|UniProtKB:Q9NYP3}.
CC   -!- SIMILARITY: Belongs to the DONSON family. {ECO:0000255}.
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DR   EMBL; CR760582; CAJ81285.1; -; mRNA.
DR   EMBL; BC064871; AAH64871.1; -; mRNA.
DR   RefSeq; NP_989384.1; NM_204053.1.
DR   AlphaFoldDB; Q6P1U0; -.
DR   STRING; 8364.ENSXETP00000058025; -.
DR   PaxDb; Q6P1U0; -.
DR   Ensembl; ENSXETT00000058025; ENSXETP00000058025; ENSXETG00000027925.
DR   GeneID; 395018; -.
DR   KEGG; xtr:395018; -.
DR   CTD; 29980; -.
DR   Xenbase; XB-GENE-1007401; donson.
DR   eggNOG; KOG4734; Eukaryota.
DR   HOGENOM; CLU_021567_0_0_1; -.
DR   InParanoid; Q6P1U0; -.
DR   OrthoDB; 479613at2759; -.
DR   PhylomeDB; Q6P1U0; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027925; Expressed in 4-cell stage embryo and 8 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005657; C:replication fork; ISS:UniProtKB.
DR   GO; GO:0030894; C:replisome; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0006260; P:DNA replication; ISS:UniProtKB.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0033260; P:nuclear DNA replication; IBA:GO_Central.
DR   GO; GO:0048478; P:replication fork protection; ISS:UniProtKB.
DR   InterPro; IPR024861; Donson.
DR   PANTHER; PTHR12972; PTHR12972; 1.
DR   PRINTS; PR02064; DONSON.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Developmental protein; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..577
FT                   /note="Protein downstream neighbor of son homolog"
FT                   /id="PRO_0000236813"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..379
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   577 AA;  63773 MW;  4AB2BD742ABD7CAF CRC64;
     MAELLPGYSP SFKKPSEILR LSRRRSRSEA SKAGVSPFSP GDVTKRVPGL RPFSPGPNKG
     AGVKRRNPFA NLENTVCSPV KRRAESVPEC ASPEPRALVA ARPSCWELGS PSPQPPQFNS
     VEDVIWGDPL ADPLVKTESP EKPATACETP KGSVTFPADW SLKTRLLFTS SQSFSWADHL
     KAQEEAQGLV MHCRATAVSL PHSIQEPKLS TELRCAFQQS LVHWVHPSFP WVQLFPRIGI
     DRKMVGKNSP WSHDESLQQV IMSEWALSFT SLYNLLKAKL CPYFYVCTYQ FTVLFRAAGL
     AGSDVITAVM SPTTRGLREA MKNEGITFTQ PLVEEDPSKK QKNSEANSQG DITPKKENGN
     TETDEVSDES DEDESFSWLE EMGVEDKIKK PDSISIKLRK EKNEVKLDHK PESVVLVKGT
     NTFTLLNFLI NCKSIVAAAG PQAGLPPTLL SPVAFRGATM QTLKARSVNV KTQVRSGYKD
     QFSLEITGPI MPHSLHSLTM LLQSAQRGSF SAGFYSHDPT AVFNTPIHPQ AAKEISADLQ
     NCGLHPSTVE QLSQVNQLGK LSLRHLELSD YRYTWKS