DOP1_DROPS
ID DOP1_DROPS Reviewed; 2629 AA.
AC Q292H2;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Protein dopey-1 homolog;
GN ORFNames=GA13490;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: May be involved in protein traffic between late Golgi and
CC early endosomes. {ECO:0000250|UniProtKB:Q03921}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q03921}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q03921}.
CC -!- SIMILARITY: Belongs to the dopey family. {ECO:0000305}.
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DR EMBL; CM000071; EAL24890.1; -; Genomic_DNA.
DR AlphaFoldDB; Q292H2; -.
DR IntAct; Q292H2; 1.
DR STRING; 7237.FBpp0277014; -.
DR PRIDE; Q292H2; -.
DR eggNOG; KOG3613; Eukaryota.
DR HOGENOM; CLU_001045_0_0_1; -.
DR InParanoid; Q292H2; -.
DR OMA; QFQRNST; -.
DR PhylomeDB; Q292H2; -.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006895; P:Golgi to endosome transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR040314; DOP1.
DR InterPro; IPR007249; Dopey_N.
DR PANTHER; PTHR14042; PTHR14042; 1.
DR Pfam; PF04118; Dopey_N; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..2629
FT /note="Protein dopey-1 homolog"
FT /id="PRO_0000297954"
FT REGION 561..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1278..1340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1371..1395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1435..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1766..1785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1292..1308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1317..1331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1378..1394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1435..1453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1771..1785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2629 AA; 293713 MW; AF946986F63F6225 CRC64;
MESADALMEE QKLMAEAKYR NYMTNIDKAL RNFEYSSEWA DLISALGKLS KAISSNTQYQ
VIPRRLKIAK RLAQCMHPAL PSGVHLKALE TYSVIFSKTG PERLATEFIY SAGLFPLLGY
AAMNVRPALL AIYETYFVPL GDKLRPALSG FLNGVLPGYD CGLDHFERIS ALLKQVCNAV
NPMHFYTVLW ESVANNAAIR LPAITYLLEH FNKRLDMQEQ IYVMGHNREI MMSALCACLN
DSLILVQRNT LEFLLLGFPM HTALLAEDDL VKLVTNGLNT ILRRDMSLNR RLFSWLLGSE
VAKNSPTYDT LSLDASATPL DEPPEPYFVK HSRHILIRAL ITTLRLSLEC APMDLKPYRI
MLSLLDKAEI GSAVLDYVLH DIIRAMYISS GNPEALKSAN LLFATFDPAY IWSYMTNMFE
RACHQANSSD KQDKLLPQAS AEGGDKFACE VGSGDPCVLE ICVLTEFLLE TVSLEMYTET
TRVYLPKVFL AITQLLSLHM DRVTSSEITA SLKLCMKIVS RVQPMITSPI KLNKLMEQQC
AGSSSDEKIT VNAAAAIDSA NKGVPGTHTQ GSSLEKSKSD SRLNQFAENS LQSADPNDED
LIRRSASNQS VGRQSPSKKK AKSISRLSEL DKDISASDTG QQSSSDLDTP RSIKKLKAKA
KVPFIRSPKK QRPKDIVLVQ SAAVVDSAGN VHDAEEPKSA PPDPQSPQFY LDDESQATQQ
RGYSILEKCI RQYEIFFEVY VARKLLQIES DGMSESSVKV QLQRSTSIHS SSHTSSLFLV
EQVLEYECPI RESQIERLFN LLRVDKVPRS KQLQRLLNHS LPLLASASEL SSDSEATEAP
ERQTQSLLID TQTQRGVQQL AELQLSLSMR GAVKLAASLL VEMSTFPNCN KHIVLDRSEP
ELPNWLKVLC LVACFAQSDK ELQVSAITTL FDLISLLRSQ IEHTTSPGVT FVVMLPLLKF
GHVSYMEQQT RVFQLVSSIL WDYLGASCTD PAQTVALLHQ LHSCLESGLV ETVIGNRMQA
QHLLQIQPIP GVGRTALRSF QLERLGDAQL LCPTESTERL RESQARSFKK FELLWHLGRD
KQTSRGFEKT LLKVLDTLAL PHYMSERTFV TNWLQASLLR GDLARLTKPL YKILLSANSK
RVGIVHMQQL YRESAEAEGD TAPAFERDVY AISSEQGNVK YHHMETTSGA KKKSPIRNLP
KKIFGVTLSG GKTNKTSNFV SDKTALATEA AQDVNTIGLI INPLENATDF DDETDLEEPR
IEIPHKETPL EQKLACAMDE SDQPSAQEQP PPPSQQQQDQ SSHFDQDITD NSDSSDFESD
SELRETSLEK EDSITVSSSA GVSDDVKRFV GDCERVTEAL TQHEKIKSRK TYRLTREKTP
GENSLNSVAT DQTEHSLADM HADALPADEY FREDKKLGKR KKLLTSSDKK RLSCISKTST
DSNLSNSCSQ AEPAPEGDPQ GEEEATAATD STINVEDKRR NLSLETSKLQ PDWQKALEKG
KQNVEILRQN AAAAAAAEEQ TSLRSSMKSS SSLADAAHLY HNHLLLYLAI YDTRQTLYAL
QTLRNIICCD KRTFLCLSIT TSFSSASLKQ LLVRHRKSIS GKGFDGSVGN SEYAQGYRGC
MQLELLVTLC LFYARGYFQR ESLDAQRQSP TLQDIVNNRR IQLESIELLT LICSELIEIV
KGMGRGLACY IADLLARAKL QKVMLHCLNS SVCSYGRRAP TGSYAEQVLS FNDPQDDQLH
ADCFQLQLLR LLLSVIRLEH EVHQLRQDTP PAAGDDSTGN TSPTRLAEGA AANVKYLPNC
LISQQPMFLA AVLGALQQER LRHLHRNWTD LVTSSLNCFT FGSLTNIVIS VVHQLCNNLD
RMARLGLQQQ RHFPPDYVLS QLEALTILCH YCLLDNTQQT ALSHLFNQAY PQTSSSAQSS
STSQLLNSFV HSFLSANESS TGTSAPAPRN PQLQAARNAV LSHLPRIMSS VAAIWDSELG
QLRPVRQQLM EFLSPVSLHH GCNFLAAVAV TWQQRGSSNA SNGSGLSISD QFQRNSTLQA
CPGQLSLVSL VSSIRVMPMD SFVMTLHQVV RSPPPIHRPP AHLSIEVSAL ELFYFYMKSA
PGTQLADAWS SLLALIRDGL NLSPPAQFAL LMLLNEFVQR CPQMPFQDKK EVRELHDVTS
RLVDSLSGVA GSCLEQTTWL RRNLAVKEDT DGLAKDNSIG GGGGIQQYSL QAQSVLATIL
SNLLDVAYGS QEKDKVVNIV TPLLYNITPY LKNHTARNVP FFYACSALLA SLSGYQYTRK
AWRKDMLDLL LDNSFFQMHI SCLPFWRMIM DSLMTYDNTT FRELMTRVSL SQAGSLNIFT
SREQEFEQRG MLLKRLAFVI YCSEFDQHNK YMPDIQEQLA NSLRLVPMGP SVQAAVFLCF
RVLLLRMSPD HVTSLWPIII AEMVQVFLQM EQELKSESEE RSQQMRLPSS IDVSWSNNSG
ASNGINAQTP MQHWRSVQLE ACKLLELGCV LPATKLPHFQ MYRWAFVGTE FDVHEEEVGL
PNGSLENLAT LPTALYVPHV RRVARLMDMK YTSQSPLLQR PSNRHLMLNF QQLQSLQELY
AFFSTLGISC PQPRNFADTE RDVANCLEEI EDVLANDFLE KLPSLTTPR
