ID   DOP1_EMENI              Reviewed;        1858 AA.
AC   Q9Y7B3; C8VLX2; Q5BBI6;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Protein dopey;
GN   Name=dop1; ORFNames=AN2094;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DOMAINS, AND MUTAGENESIS OF ILE-1695.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=10931277; DOI=10.1046/j.1365-2958.2000.01950.x;
RA   Pascon R.C., Miller B.L.;
RT   "Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a
RT   novel family of leucine zipper-like proteins conserved from yeast to
RT   humans.";
RL   Mol. Microbiol. 36:1250-1264(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Involved in cellular morphogenesis. Required for traffic
CC       between late Golgi and early endosomes, and for the normal structure
CC       and organization of the endoplasmic reticulum (By similarity). During
CC       the vegetative phase, contributes to the highly polarized hyphal
CC       growth. Required for the reproductive cycle. Involved in conidiophore
CC       initiation and differentiation. May have a role in controlling the
CC       balance between vegetative proliferation and developmental
CC       morphogenesis. {ECO:0000250, ECO:0000269|PubMed:10931277}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Note=Late Golgi.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dopey family. {ECO:0000305}.
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DR   EMBL; AF134206; AAD28280.1; -; mRNA.
DR   EMBL; AACD01000032; EAA64926.1; -; Genomic_DNA.
DR   EMBL; BN001307; CBF86166.1; -; Genomic_DNA.
DR   RefSeq; XP_659698.1; XM_654606.1.
DR   AlphaFoldDB; Q9Y7B3; -.
DR   STRING; 162425.CADANIAP00008766; -.
DR   EnsemblFungi; CBF86166; CBF86166; ANIA_02094.
DR   EnsemblFungi; EAA64926; EAA64926; AN2094.2.
DR   GeneID; 2874634; -.
DR   KEGG; ani:AN2094.2; -.
DR   VEuPathDB; FungiDB:AN2094; -.
DR   eggNOG; KOG3613; Eukaryota.
DR   HOGENOM; CLU_001197_1_0_1; -.
DR   InParanoid; Q9Y7B3; -.
DR   OMA; WIFITDT; -.
DR   OrthoDB; 29961at2759; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0000902; P:cell morphogenesis; IMP:AspGD.
DR   GO; GO:0070791; P:cleistothecium development; IMP:AspGD.
DR   GO; GO:0048315; P:conidium formation; IMP:AspGD.
DR   GO; GO:0006895; P:Golgi to endosome transport; IEA:InterPro.
DR   GO; GO:0070798; P:positive regulation of cleistothecium development; IMP:AspGD.
DR   GO; GO:0075307; P:positive regulation of conidium formation; IMP:AspGD.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040314; DOP1.
DR   InterPro; IPR007249; Dopey_N.
DR   PANTHER; PTHR14042; PTHR14042; 1.
DR   Pfam; PF04118; Dopey_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome; Repeat;
KW   Transport.
FT   CHAIN           1..1858
FT                   /note="Protein dopey"
FT                   /id="PRO_0000190975"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1052..1092
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1838..1854
FT                   /note="Transactivation"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1067..1085
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         1695
FT                   /note="I->R: Inactivated function at 42 degrees Celsius.
FT                   Altered cellular morphology and cell pattern formation."
FT                   /evidence="ECO:0000269|PubMed:10931277"
SQ   SEQUENCE   1858 AA;  207245 MW;  9ED4B7D8CB1373E4 CRC64;
     MSLDPSSFPR SNSPASSDSS LTRSRLRGKE GSLKKDKNYR RYASSVERAL SLFDNTLQEW
     ADYISFLSRL LKALQTHPPD QPVVPHKVLV AKRLSQSMNP SLPSGVHQKA LEVYTYIFNL
     IKPEGLSHDL PLYYPGIAPT LTFASLTVRP LFLSLVETYV CDLEPWAIRP ALKAIILSLL
     PGLEEETSDD FDSTLRLLNT LREIASRMDT QRPGAETNSS GQYFWQCFFL ASITSPSRRL
     GILAYLNRYL PKLGVTDRRP SRHEEVDATA MPLEMQVAVD SVILPEPGLL IRCFATGLTD
     EQVLVQRNFL DLLVTHLPLS SPILQTRITK DDLQRLIVAA AGVVSRRDMS LNRRLWAWLL
     GPDPVGDRAS FEARPSISST ASKTAAESEE LSQSQYFSRF GLQPLASGLL QLLKRDTELP
     SEKAKPFRIT LSLMDRWEVG GHVVPAVFLP FMRSVKAYKL AAPKAHFDEV FRSATSFFDG
     VESGMIFSEL LNLIDWDAKS LANDAPRILD NLNLAHFILD HFNVREEDMV LNHAPLLTLA
     ALIKMSELSS EATTSVAHDQ LQAVSNGLSK VVTLLTGLLI DRAFLRKSDS KNSVNEPSML
     LDRPGSAILR QIHQFYDRSR NSLDLQPPPF PPTDLADLII KNVYEQAISA VNACNDAKSI
     PERLNLLIVV LKKLPRSRIL RDKRLYVAIG KHIQASTVEL STASFSHLSS MSTTITSLYC
     IHKLGYYITY EEVSDLIPPL VRQLWQFLSP LSPKFHVEAV RCLWNLHSVS WSDHLVESTI
     TSLMFTPPAP GSYQLSSEEE AGRYFILWNH SHHGTYELPP KNLQDSAQSQ ASYHSSMLER
     PLFTVLDLLS QGSTQPAQVV QLWLQDLPSV AKVFRIIISK LEGVLHRGNQ LGTFEGNTVV
     SPDDYAECNY LFETIHNVLG ALNHNGWVSL LTQTMAHNSR RHDASASEDN AEAPSLHSVV
     FQASLKIVSG YKSGTATANA EEVKLQQISL LVMRQLLLGP GVEELVESGI DSLLVDRLYS
     MLDEGGDIAI QAALIDTLLA VLKARFSQAY LPPPPTKPKH QRGGSREKLT SPSLLSFTSD
     KPEKSSVLLP SPEPPQRLLD CLLKGLSSPR SRAIIDKWIM LLCEILPIYS TCIFQILLTL
     VDCLGREIRQ SYTNLQSAFE KTEGWPKDRP EQTTISLLTG FETCIAAAHE RLLMEEVNAP
     AAKSPDQTHG FFGNMVSGVF ASDSNHPRSA AMNNRLTVLL SFQDAVRLCF SIWSWGAAER
     SSLPQDTESI ASFQYTSLRM RNRSRRILEH LFTAEALECL ETMVDMWIKS DRDTSPLIFN
     LLHTLDGSRP KIAIPAIFNA IYTRTNPAAL DPSRKSTMTT ALTETELAGF LVTYARSLDD
     DVLDEIWIDC TTFLRDVLSN PFPHRQILPR LVEFAAILGV KLENTNFGED RRMRKELGDV
     ILRLLTAIFT SKPMGFTQEQ GLLGRASLDY DSSSIQRIGP DDMLSILVAS MPAFSMTLGD
     MDRITTAVSN ISTNIIGPFI RARLFPNNLN TSFMALMQHI SKIPQVAKVW KKDVADAFND
     PRFFGSQLDL VKGGWMTLLR QWALVDKDRL SEIMTRLTPP ATAGIMFGVG ASAARLDADR
     KAQLNLRRIS LLVLSTAEDY FIAEMPALLQ KLEDLLGATA SSSPSSATRA EIFMVLRALI
     LKSTTTTLSP FWPLINSELQ EAISAISSGN QQELYNPYSL LQACKLLDTL LVLAPDDFQL
     LEWLYVTDTV DAIYPPEQFE PTALADEVSH NLGVRWSTSS DPTRESTNLH HGVRYPGLAA
     DWIRETAKDE IVDRVLRPFF DQLSIHAFES TYSISNPNLE ACRDDLLADL FNESTMAN